product summary
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company name :
Alomone Labs
product type :
antibody
product name :
Anti-TRPV1 (VR1) Antibody
catalog :
ACC-030
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
clone name :
NA
reactivity :
human, mouse, rat, pigs
application :
western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - frozen section, immunohistochemistry - free floating section, western blot knockout validation
more info or order :
citations: 94
Published Application/Species/Sample/DilutionReference
  • western blot knockout validation; mouse; 1:1000; loading ...; fig s2a
Liu B, Cao Q, Zhao X, Liu H, Zhang Y. Inhibition of TRPV1 by SHP-1 in nociceptive primary sensory neurons is critical in PD-L1 analgesia. JCI Insight. 2020;5: pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:100; loading ...; fig 7l
Karpinski B, Maynard T, Bryan C, Yitsege G, Horvath A, Lee N, et al. Selective disruption of trigeminal sensory neurogenesis and differentiation in a mouse model of 22q11.2 deletion syndrome. Dis Model Mech. 2022;15: pubmed publisher
  • western blot; mouse; 1:200; loading ...
Xie M, Cao X, Zeng W, Lai R, Guo L, Wang J, et al. ATF4 selectively regulates heat nociception and contributes to kinesin-mediated TRPM3 trafficking. Nat Commun. 2021;12:1401 pubmed publisher
  • immunohistochemistry - frozen section; pigs ; 1:200; loading ...; fig 2b
Toschi A, Galiazzo G, Piva A, Tagliavia C, Mazzuoli Weber G, Chiocchetti R, et al. Cannabinoid and Cannabinoid-Related Receptors in the Myenteric Plexus of the Porcine Ileum. Animals (Basel). 2021;11: pubmed publisher
  • immunocytochemistry; mouse; loading ...; fig 4e
Trevisan A, Bauer M, Brindley R, Currie K, Carter B. Jedi-1 deficiency increases sensory neuron excitability through a non-cell autonomous mechanism. Sci Rep. 2020;10:1300 pubmed publisher
  • immunohistochemistry - frozen section; mouse; loading ...; fig s1a
Cohen J, Edwards T, Liu A, Hirai T, Jones M, Wu J, et al. Cutaneous TRPV1+ Neurons Trigger Protective Innate Type 17 Anticipatory Immunity. Cell. 2019;178:919-932.e14 pubmed publisher
  • immunohistochemistry - free floating section; mouse; 1:1000; loading ...; fig 4b
Huang T, Lin S, Malewicz N, Zhang Y, Zhang Y, Goulding M, et al. Identifying the pathways required for coping behaviours associated with sustained pain. Nature. 2019;565:86-90 pubmed publisher
  • immunocytochemistry; human; 1:500; fig 3b
Alshawaf A, Viventi S, Qiu W, D Abaco G, Nayagam B, Erlichster M, et al. Phenotypic and Functional Characterization of Peripheral Sensory Neurons derived from Human Embryonic Stem Cells. Sci Rep. 2018;8:603 pubmed publisher
  • immunocytochemistry; rat; fig 4c
  • western blot; rat; 1:200; fig 4b
Hu Y, Mi X, Huang C, Wang H, Song J, Shu Q, et al. Multiple H+ sensors mediate the extracellular acidification-induced [Ca2+]i elevation in cultured rat ventricular cardiomyocytes. Sci Rep. 2017;7:44951 pubmed publisher
Oh S, Lim J, Son M, Ahn J, Song K, Lee H, et al. TRPV1 inhibition overcomes cisplatin resistance by blocking autophagy-mediated hyperactivation of EGFR signaling pathway. Nat Commun. 2023;14:2691 pubmed publisher
Omari S, Geraghty D, Khalafallah A, Venkat P, Shegog Y, Ragg S, et al. Optimized flow cytometric detection of transient receptor potential vanilloid-1 (TRPV1) in human hematological malignancies. Med Oncol. 2022;39:81 pubmed publisher
Chakraborty R, Acharya T, Tiwari N, Majhi R, Kumar S, Goswami L, et al. Hydrogel-Mediated Release of TRPV1 Modulators to Fine Tune Osteoclastogenesis. ACS Omega. 2022;7:9537-9550 pubmed publisher
Hsiao I, Lin Y. Electroacupuncture Reduces Fibromyalgia Pain by Attenuating the HMGB1, S100B, and TRPV1 Signalling Pathways in the Mouse Brain. Evid Based Complement Alternat Med. 2022;2022:2242074 pubmed publisher
Becker J, Papagianni A, Herrmann E, N xf6 ller F, Sommer C, Rittner H. Transient hypoalgesia after COVID-19 infection. Pain Rep. 2022;7:e990 pubmed publisher
Belinskaia M, Zurawski T, Kaza S, Antoniazzi C, Dolly J, Lawrence G. NGF Enhances CGRP Release Evoked by Capsaicin from Rat Trigeminal Neurons: Differential Inhibition by SNAP-25-Cleaving Proteases. Int J Mol Sci. 2022;23: pubmed publisher
Li L, Ma L, Luo Z, Wei X, Zhao Y, Zhou C, et al. Lack of TRPV1 aggravates obesity-associated hypertension through the disturbance of mitochondrial Ca2+ homeostasis in brown adipose tissue. Hypertens Res. 2022;45:789-801 pubmed publisher
Hornung R, Raut N, Cantu D, Lockhart L, Averitt D. Sigma-1 receptors and progesterone metabolizing enzymes in nociceptive sensory neurons of the female rat trigeminal ganglia: A neural substrate for the antinociceptive actions of progesterone. Mol Pain. 2022;18:17448069211069255 pubmed publisher
Grelet S, Fr xe9 reux C, Obellianne C, Noguchi K, Howley B, Dalton A, et al. TGFβ-induced expression of long noncoding lincRNA Platr18 controls breast cancer axonogenesis. Life Sci Alliance. 2022;5: pubmed publisher
Barr J, Kruse A, Restaino A, Tulina N, Stuckelberger S, Vermeer S, et al. Intra-Tumoral Nerve-Tracing in a Novel Syngeneic Model of High-Grade Serous Ovarian Carcinoma. Cells. 2021;10: pubmed publisher
Nakazawa Y, Petrova R, Sugiyama Y, Nagai N, Tamura H, Donaldson P. Regulation of the Membrane Trafficking of the Mechanosensitive Ion Channels TRPV1 and TRPV4 by Zonular Tension, Osmotic Stress and Activators in the Mouse Lens. Int J Mol Sci. 2021;22: pubmed publisher
Li J, Chen Y, Liu J, Zhang D, Liang P, Lu P, et al. Elevated Expression and Activity of Sodium Leak Channel Contributes to Neuronal Sensitization of Inflammatory Pain in Rats. Front Mol Neurosci. 2021;14:723395 pubmed publisher
Zhang Y, Ma S, Ke X, Yi Y, Yu H, Yu D, et al. The mechanism of Annexin A1 to modulate TRPV1 and nociception in dorsal root ganglion neurons. Cell Biosci. 2021;11:167 pubmed publisher
Giuliano C, Francavilla M, Ongari G, Petese A, Ghezzi C, Rossini N, et al. Neuroprotective and Symptomatic Effects of Cannabidiol in an Animal Model of Parkinson's Disease. Int J Mol Sci. 2021;22: pubmed publisher
Wang W, Kong M, Dou Y, Xue S, Liu Y, Zhang Y, et al. Selective Expression of a SNARE-Cleaving Protease in Peripheral Sensory Neurons Attenuates Pain-Related Gene Transcription and Neuropeptide Release. Int J Mol Sci. 2021;22: pubmed publisher
Sattler K, El Battrawy I, Cyganek L, Lang S, Lan H, Li X, et al. TRPV1 activation and internalization is part of the LPS-induced inflammation in human iPSC-derived cardiomyocytes. Sci Rep. 2021;11:14689 pubmed publisher
Xue C, Liu S, Hu J, Huang J, Liu H, Qiu Z, et al. Corydalis saxicola Bunting total alkaloids attenuate paclitaxel-induced peripheral neuropathy through PKCε/p38 MAPK/TRPV1 signaling pathway. Chin Med. 2021;16:58 pubmed publisher
Jiao H, Ivanusic J, McMenamin P, Chinnery H. Distribution of Corneal TRPV1 and Its Association With Immune Cells During Homeostasis and Injury. Invest Ophthalmol Vis Sci. 2021;62:6 pubmed publisher
Makhmutova M, Caicedo A. Optical Imaging of Pancreatic Innervation. Front Endocrinol (Lausanne). 2021;12:663022 pubmed publisher
Pascual Go xf1 i E, Fehmi J, Lleix xe0 C, Mart xed n Aguilar L, Devaux J, H xf6 ftberger R, et al. Antibodies to the Caspr1/contactin-1 complex in chronic inflammatory demyelinating polyradiculoneuropathy. Brain. 2021;144:1183-1196 pubmed publisher
Landy M, Goyal M, Casey K, Liu C, Lai H. Loss of Prdm12 during development, but not in mature nociceptors, causes defects in pain sensation. Cell Rep. 2021;34:108913 pubmed publisher
Zhang Y, Li C, Qin Y, Cepparulo P, Millman M, Chopp M, et al. Small extracellular vesicles ameliorate peripheral neuropathy and enhance chemotherapy of oxaliplatin on ovarian cancer. J Extracell Vesicles. 2021;10:e12073 pubmed publisher
Nakazawa Y, Doki Y, Sugiyama Y, Kobayashi R, Nagai N, Morisita N, et al. Effect of Alpha-Glucosyl-Hesperidin Consumption on Lens Sclerosis and Presbyopia. Cells. 2021;10: pubmed publisher
Morgan M, Thai J, Trinh P, Habib M, Effendi K, Ivanusic J. ASIC3 inhibition modulates inflammation-induced changes in the activity and sensitivity of Aδ and C fiber sensory neurons that innervate bone. Mol Pain. 2020;16:1744806920975950 pubmed publisher
Ando M, Hayashi Y, Hitomi S, Shibuta I, Furukawa A, Oto T, et al. Oxytocin-Dependent Regulation of TRPs Expression in Trigeminal Ganglion Neurons Attenuates Orofacial Neuropathic Pain Following Infraorbital Nerve Injury in Rats. Int J Mol Sci. 2020;21: pubmed publisher
Duo L, Wu T, Ke Z, Hu L, Wang C, Teng G, et al. Gain of Function of Ion Channel TRPV1 Exacerbates Experimental Colitis by Promoting Dendritic Cell Activation. Mol Ther Nucleic Acids. 2020;22:924-936 pubmed publisher
Leo M, Schmitt L, K xfc sterarent P, Kutritz A, Rassaf T, Kleinschnitz C, et al. Platinum-Based Drugs Cause Mitochondrial Dysfunction in Cultured Dorsal Root Ganglion Neurons. Int J Mol Sci. 2020;21: pubmed publisher
Wang Y, Mo X, Ping C, Huang Q, Zhang H, Xie C, et al. Site-specific contacts enable distinct modes of TRPV1 regulation by the potassium channel Kvβ1 subunit. J Biol Chem. 2020;295:17337-17348 pubmed publisher
Lin Y, Chou A, Su H, Su K. Transient receptor potential V1 (TRPV1) modulates the therapeutic effects for comorbidity of pain and depression: The common molecular implication for electroacupuncture and omega-3 polyunsaturated fatty acids. Brain Behav Immun. 2020;89:604-614 pubmed publisher
Otto M, Bucher C, Liu W, Muller M, Schmidt T, Kardell M, et al. 12(S)-HETE mediates diabetes-induced endothelial dysfunction by activating intracellular endothelial cell TRPV1. J Clin Invest. 2020;130:4999-5010 pubmed publisher
Mailhot B, Christin M, Tessandier N, Sotoudeh C, Bretheau F, Turmel R, et al. Neuronal interleukin-1 receptors mediate pain in chronic inflammatory diseases. J Exp Med. 2020;217: pubmed publisher
Meleine M, Mounien L, Atmani K, Ouelaa W, B xf4 le Feysot C, Gu xe9 rin C, et al. Ghrelin inhibits autonomic response to gastric distension in rats by acting on vagal pathway. Sci Rep. 2020;10:9986 pubmed publisher
Schoepf C, Zeidler M, Spiecker L, Kern G, Lechner J, Kummer K, et al. Selected Ionotropic Receptors and Voltage-Gated Ion Channels: More Functional Competence for Human Induced Pluripotent Stem Cell (iPSC)-Derived Nociceptors. Brain Sci. 2020;10: pubmed publisher
Han G, Chay D, Nam S, Cho H, Chung J, Kim J. Prognostic Significance of Transient Receptor Potential Vanilloid Type 1 (TRPV1) and Phosphatase and Tension Homolog (PTEN) in Epithelial Ovarian Cancer. Cancer Genomics Proteomics. 2020;17:309-319 pubmed publisher
Zhang B, Zhang Y, Sun Q, Zhang P, Wang X, Xu G, et al. Alpha-lipoic acid downregulates TRPV1 receptor via NF-κB and attenuates neuropathic pain in rats with diabetes. CNS Neurosci Ther. 2020;26:762-772 pubmed publisher
Inprasit C, Huang Y, Lin Y. Evidence for acupoint catgut embedding treatment and TRPV1 gene deletion increasing weight control in murine model. Int J Mol Med. 2020;45:779-792 pubmed publisher
Liao C, Li J, Hsieh C. Auricular Electrical Stimulation Alleviates Headache through CGRP/COX-2/TRPV1/TRPA1 Signaling Pathways in a Nitroglycerin-Induced Migraine Rat Model. Evid Based Complement Alternat Med. 2019;2019:2413919 pubmed publisher
Li Y, Yin C, Li X, Liu B, Wang J, Zheng X, et al. Electroacupuncture Alleviates Paclitaxel-Induced Peripheral Neuropathic Pain in Rats via Suppressing TLR4 Signaling and TRPV1 Upregulation in Sensory Neurons. Int J Mol Sci. 2019;20: pubmed publisher
Chiocchetti R, Galiazzo G, Tagliavia C, Stanzani A, Giancola F, Menchetti M, et al. Cellular Distribution of Canonical and Putative Cannabinoid Receptors in Canine Cervical Dorsal Root Ganglia. Front Vet Sci. 2019;6:313 pubmed publisher
Yap J, Tai Y, Fröhlich J, Fong C, Yin J, Foo Z, et al. Ambient and supplemental magnetic fields promote myogenesis via a TRPC1-mitochondrial axis: evidence of a magnetic mitohormetic mechanism. FASEB J. 2019;33:12853-12872 pubmed publisher
Yen C, Wu T, Hsieh C, Huang Y, Lin Y. Distal Electroacupuncture at the LI4 Acupoint Reduces CFA-Induced Inflammatory Pain via the Brain TRPV1 Signaling Pathway. Int J Mol Sci. 2019;20: pubmed publisher
Recla J, Bubier J, Gatti D, Ryan J, Long K, Robledo R, et al. Genetic mapping in Diversity Outbred mice identifies a Trpa1 variant influencing late-phase formalin response. Pain. 2019;160:1740-1753 pubmed publisher
Jiang M, Li H, Johnson A, Karasawa T, Zhang Y, Meier W, et al. Inflammation up-regulates cochlear expression of TRPV1 to potentiate drug-induced hearing loss. Sci Adv. 2019;5:eaaw1836 pubmed publisher
Nakazawa Y, Donaldson P, Petrova R. Verification and spatial mapping of TRPV1 and TRPV4 expression in the embryonic and adult mouse lens. Exp Eye Res. 2019;:107707 pubmed publisher
Li M, Zhang C, Zong Y, Feng J, Ma T, Hu M, et al. Transient Receptor Potential V Channels Are Essential for Glucose Sensing by Aldolase and AMPK. Cell Metab. 2019;: pubmed publisher
BARTSCH V, Niehaus J, Taylor Blake B, Zylka M. Enhanced histamine-induced itch in diacylglycerol kinase iota knockout mice. PLoS ONE. 2019;14:e0217819 pubmed publisher
Kim K, Baek J, Jeong J, Nam J, Park E, Bok E, et al. Delayed Treatment of Capsaicin Produces Partial Motor Recovery by Enhancing Dopamine Function in MPP+-lesioned Rats via Ciliary Neurotrophic Factor. Exp Neurobiol. 2019;28:289-299 pubmed publisher
Ong J, Kinsman B, Sved A, Rush B, Tan R, Carattino M, et al. Renal sensory nerves increase sympathetic nerve activity and blood pressure in 2-kidney 1-clip hypertensive mice. J Neurophysiol. 2019;122:358-367 pubmed publisher
Yang Y, Wang S, Kobayashi K, Hao Y, Kanda H, Kondo T, et al. TRPA1-expressing lamina propria mesenchymal cells regulate colonic motility. JCI Insight. 2019;4: pubmed publisher
Lucido C, Wynja E, Madeo M, Williamson C, Schwartz L, Imblum B, et al. Innervation of cervical carcinoma is mediated by cancer-derived exosomes. Gynecol Oncol. 2019;154:228-235 pubmed publisher
Morgan M, Nencini S, Thai J, Ivanusic J. TRPV1 activation alters the function of Aδ and C fiber sensory neurons that innervate bone. Bone. 2019;123:168-175 pubmed publisher
Liu B, Qiu M, Zong P, Chen X, Zhao K, Li Y, et al. Distribution, Morphological Characterization, and Resiniferatoxin-Susceptibility of Sensory Neurons That Innervate Rat Perirenal Adipose Tissue. Front Neuroanat. 2019;13:29 pubmed publisher
Guo S, Lin J, Huang L, Yang Y, Chen C, Li N, et al. Silencing of spinal Trpv1 attenuates neuropathic pain in rats by inhibiting CAMKII expression and ERK2 phosphorylation. Sci Rep. 2019;9:2769 pubmed publisher
Huang R, Wang F, Yang Y, Ma W, Lin Z, Cheng N, et al. Recurrent activations of transient receptor potential vanilloid-1 and vanilloid-4 promote cellular proliferation and migration in esophageal squamous cell carcinoma cells. FEBS Open Bio. 2019;9:206-225 pubmed publisher
Meents J, Bressan E, Sontag S, Foerster A, Hautvast P, R xf6 sseler C, et al. The role of Nav1.7 in human nociceptors: insights from human induced pluripotent stem cell-derived sensory neurons of erythromelalgia patients. Pain. 2019;160:1327-1341 pubmed publisher
Noseda R, Melo Carrillo A, Nir R, Strassman A, Burstein R. Non-Trigeminal Nociceptive Innervation of the Posterior Dura: Implications to Occipital Headache. J Neurosci. 2019;39:1867-1880 pubmed publisher
Hossain M, Ando H, Unno S, Masuda Y, Kitagawa J. Activation of TRPV1 and TRPM8 Channels in the Larynx and Associated Laryngopharyngeal Regions Facilitates the Swallowing Reflex. Int J Mol Sci. 2018;19: pubmed publisher
Türker E, Garreis F, Khajavi N, Reinach P, Joshi P, Brockmann T, et al. Vascular Endothelial Growth Factor (VEGF) Induced Downstream Responses to Transient Receptor Potential Vanilloid 1 (TRPV1) and 3-Iodothyronamine (3-T1AM) in Human Corneal Keratocytes. Front Endocrinol (Lausanne). 2018;9:670 pubmed publisher
Bou Karam J, Cai W, Mohamed R, Huang T, Meng L, HOMAN E, et al. TRPV1 neurons regulate β-cell function in a sex-dependent manner. Mol Metab. 2018;18:60-67 pubmed publisher
Zhang W, Drzymalski D, Sun L, Xu Q, Jiao C, Wang L, et al. Involvement of mGluR5 and TRPV1 in visceral nociception in a rat model of uterine cervical distension. Mol Pain. 2018;14:1744806918816850 pubmed publisher
Baek J, Jeong J, Kim K, Won S, Chung Y, Nam J, et al. Inhibition of Microglia-Derived Oxidative Stress by Ciliary Neurotrophic Factor Protects Dopamine Neurons In Vivo from MPP⁺ Neurotoxicity. Int J Mol Sci. 2018;19: pubmed publisher
Madeo M, Colbert P, Vermeer D, Lucido C, Cain J, Vichaya E, et al. Cancer exosomes induce tumor innervation. Nat Commun. 2018;9:4284 pubmed publisher
Jeong J, Lee D, Liu S, Chua S, Schwartz G, Jo Y. Activation of temperature-sensitive TRPV1-like receptors in ARC POMC neurons reduces food intake. PLoS Biol. 2018;16:e2004399 pubmed publisher
Wang Y, Gao Y, Tian Q, Deng Q, Wang Y, Zhou T, et al. TRPV1 SUMOylation regulates nociceptive signaling in models of inflammatory pain. Nat Commun. 2018;9:1529 pubmed publisher
Alamri A, Wood R, Ivanusic J, Brock J. The neurochemistry and morphology of functionally identified corneal polymodal nociceptors and cold thermoreceptors. PLoS ONE. 2018;13:e0195108 pubmed publisher
Yang J, Hsieh C, Lin Y. Role of Transient Receptor Potential Vanilloid 1 in Electroacupuncture Analgesia on Chronic Inflammatory Pain in Mice. Biomed Res Int. 2017;2017:5068347 pubmed publisher
Ortíz Rentería M, Juárez Contreras R, González Ramírez R, Islas L, Sierra Ramírez F, Llorente I, et al. TRPV1 channels and the progesterone receptor Sig-1R interact to regulate pain. Proc Natl Acad Sci U S A. 2018;115:E1657-E1666 pubmed publisher
Nie J, Liu X. Quercetin alleviates generalized hyperalgesia in mice with induced adenomyosis. Mol Med Rep. 2017;16:5370-5376 pubmed publisher
Lu P, Hudgins R, Liu X, Ford Z, Hofmann M, Queme L, et al. Upregulation of P2Y1 in neonatal nociceptors regulates heat and mechanical sensitization during cutaneous inflammation. Mol Pain. 2017;13:1744806917730255 pubmed publisher
Leo M, Schulte M, Schmitt L, Sch xe4 fers M, Kleinschnitz C, Hagenacker T. Intrathecal Resiniferatoxin Modulates TRPV1 in DRG Neurons and Reduces TNF-Induced Pain-Related Behavior. Mediators Inflamm. 2017;2017:2786427 pubmed publisher
Li G, Zou X, Kuang G, Ren Y, Deng C, Lin Q, et al. Preventative effects of fermented Chimonobambusa quadrangularis shoot on activated carbon-induced constipation. Exp Ther Med. 2017;13:1093-1100 pubmed publisher
Nencini S, Ringuet M, Kim D, Chen Y, Greenhill C, Ivanusic J. Mechanisms of nerve growth factor signaling in bone nociceptors and in an animal model of inflammatory bone pain. Mol Pain. 2017;13:1744806917697011 pubmed publisher
Zinn S, Sisignano M, Kern K, Pierre S, Tunaru S, Jordan H, et al. The leukotriene B4 receptors BLT1 and BLT2 form an antagonistic sensitizing system in peripheral sensory neurons. J Biol Chem. 2017;292:6123-6134 pubmed publisher
Liu C, Su H, Wan H, Qin Q, Wu X, Kong X, et al. Forsythoside A exerts antipyretic effect on yeast-induced pyrexia mice via inhibiting transient receptor potential vanilloid 1 function. Int J Biol Sci. 2017;13:65-75 pubmed publisher
De Toni L, Garolla A, Menegazzo M, Magagna S, Di Nisio A, Šabović I, et al. Heat Sensing Receptor TRPV1 Is a Mediator of Thermotaxis in Human Spermatozoa. PLoS ONE. 2016;11:e0167622 pubmed publisher
Obi S, Nakajima T, Hasegawa T, Kikuchi H, Oguri G, Takahashi M, et al. Heat induces interleukin-6 in skeletal muscle cells via TRPV1/PKC/CREB pathways. J Appl Physiol (1985). 2017;122:683-694 pubmed publisher
Yadav M, Goswami C. TRPV3 mutants causing Olmsted Syndrome induce impaired cell adhesion and nonfunctional lysosomes. Channels (Austin). 2017;11:196-208 pubmed publisher
Khoutorsky A, Sorge R, Prager Khoutorsky M, Pawlowski S, Longo G, Jafarnejad S, et al. eIF2? phosphorylation controls thermal nociception. Proc Natl Acad Sci U S A. 2016;113:11949-11954 pubmed
Doppler K, Appeltshauser L, Villmann C, Martin C, Peles E, Krämer H, et al. Auto-antibodies to contactin-associated protein 1 (Caspr) in two patients with painful inflammatory neuropathy. Brain. 2016;139:2617-2630 pubmed
Xiao Y, Chen X, Zhang P, Xu Q, Zheng H, Xu G. TRPV1-mediated presynaptic transmission in basolateral amygdala contributes to visceral hypersensitivity in adult rats with neonatal maternal deprivation. Sci Rep. 2016;6:29026 pubmed publisher
Hiyama T, Utsunomiya A, Matsumoto M, Fujikawa A, Lin C, Hara K, et al. Adipsic hypernatremia without hypothalamic lesions accompanied by autoantibodies to subfornical organ. Brain Pathol. 2017;27:323-331 pubmed publisher
Tanaka Y, Niwa S, Dong M, Farkhondeh A, Wang L, Zhou R, et al. The Molecular Motor KIF1A Transports the TrkA Neurotrophin Receptor and Is Essential for Sensory Neuron Survival and Function. Neuron. 2016;90:1215-1229 pubmed publisher
Martínez N, Abán C, Leguizamón G, Damiano A, Farina M. TPRV-1 expression in human preeclamptic placenta. Placenta. 2016;40:25-8 pubmed publisher
Bertin S, Aoki Nonaka Y, de Jong P, Nohara L, Xu H, Stanwood S, et al. The ion channel TRPV1 regulates the activation and proinflammatory properties of CD4? T cells. Nat Immunol. 2014;15:1055-1063 pubmed publisher
Sterle I, Zupancic D, Romih R. Correlation between urothelial differentiation and sensory proteins P2X3, P2X5, TRPV1, and TRPV4 in normal urothelium and papillary carcinoma of human bladder. Biomed Res Int. 2014;2014:805236 pubmed publisher
image
image 1 :
Alomone Labs ACC-030 image 1
Western blot analysis of human TRPV1 transfected HEK-293 cells: - 1. Anti-TRPV1 (VR1) Antibody (#ACC-030), (1:200).2. Anti-TRPV1 (VR1) Antibody, preincubated with TRPV1/VR1 Blocking Peptide (#BLP-CC030).
image 2 :
Alomone Labs ACC-030 image 2
Expression of TRPV1 in rat DRG - Immunohistochemical staining of rat dorsal root ganglion (DRG) using Anti-TRPV1 (VR1) Antibody (#ACC-030). A. TRPV1 (red) in DRG neurons. B. Staining with mouse anti-Parvalbumin (green) in the same DRG section. C. Confocal merge of TRPV1 and Parvalbumin demonstrates colocalization (arrows).
image 3 :
Alomone Labs ACC-030 image 3
Western blot analysis of rat DRG lysate: - 1.Anti-TRPV1 (VR1) Antibody (#ACC-030) (1:200).2. Anti-TRPV1 (VR1) Antibody preincubated with the negative control antigen.
product information
CAT :
ACC-030
SKU :
ACC-030-CF_0.2 ml
Product Name :
Anti-TRPV1 (VR1) Antibody
Group Type :
Antibodies
Product Type :
Antibodies
Clonality :
Polyclonal
Accession :
O35433
Applications :
IC IF IFC IHC WB
Reactivity :
Human Rat Mouse
Host :
Rabbit
Blocking Peptide :
BLP-CC030
Homology :
Mouse, guinea pig - 14/15 amino acid residues identical; human - 10/15 amino acid residues identical
Formulation :
PBS pH7.4
isotype :
Rabbit IgG
Peptide confirmation :
Confirmed by amino acid analysis and mass spectrometry
Reconstitution :
0.2 ml double distilled water (DDW).
Antibody Concentration After Reconstitut ... :
1 mg/ml
Storage After Reconstitution :
The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
Preservative :
No Preservative
Immunogen Location :
Intracellular, C-terminus
Label :
Unconjugated
Storage Before Reconstitution :
The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C
Shipping and storage :
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
immunogen source species :
Rat
Sequence :
(C)EDAEVFKDSMVPGEK, corresponding to amino acid residues 824-838 of rat TRPV1
Product Page - Scientific background :
TRPV1 (also named VR1, capsaicin receptor and vanilloid receptor) is a member of the transient receptor potential (TRP) channel family, which includes TRPC, TRPM, TRPA, TRPP, TRPML and the TRPV subfamilies. The TRPV subfamily consists of six members named, TRPV1-6. The TRPV1 channel is a vanilloid gated, nonselective cation channel.The channel has sequence homology to the TRP family, and shares a similar predicted structure of six transmembrane domain (TM) with a pore loop between TM5 and TM6.1 TRPV1 is expressed predominantly in nociceptors and in sensory neurons.2,3TRPV1 has many activators among them heat, protons, vanilloids like capsaicin, resiniferatoxin (RTX), and lipids. This channel is associated with tissue injury and inflammation.5,6Other members of this family, TRPV2, TRPV3 and TRPV4 also show thermal sensitivity.7 Conformational changes in the C-terminus are responsible for many functions such as permeation and gating.There is also evidence that deletion of the C-terminus causes a loss of sensitivity to any stimuli.7 Recent studies demonstrated involvement of TRPV1 in apoptosis where inhibition of the receptor prevented apoptosis.8,9
Applications may also work in :
IC IF IFC IHC WB
Supplier :
Alomone Labs
Target :
Transient receptor potential cation channel subfamily V member 1, Capsaicin receptor, Vanilloid receptor 1, OTRPC1
Short Description :
A Rabbit Polyclonal Antibody to TRPV1 (VR1) Channel
Long Description :
Anti-TRPV1 (VR1) Antibody (#ACC-030) is a highly specific antibody directed against an epitope of the rat protein. The antibody can be used in western blot, immunohistochemistry, and immunocytochemistry applications. It has been designed to recognize TRPV1 from mouse, rat, and human samples.
Negative Control :
BLP-CC030
Positive Control :
NA
Synonyms :
Transient receptor potential cation channel subfamily V member 1, Capsaicin receptor, Vanilloid receptor 1, OTRPC1
Lead Time :
1-2 Business Days
Country of origin :
Israel/IL
Applications key :
CBE- Cell-based ELISA, FC- Flow cytometry, ICC- Immunocytochemistry, IE- Indirect ELISA, IF- Immunofluorescence, IFC- Indirect flow cytometry, IHC- Immunohistochemistry, IP- Immunoprecipitation, LCI- Live cell imaging, N- Neutralization, WB- Western blot
Specifictiy :
TRPV1
Form :
Lyophilized powder. Reconstituted antibody contains phosphate buffered saline (PBS), pH 7.4.
Comment :
Contact Alomone Labs for technical support and product customization
Species reactivity key :
H- Human, M- Mouse, R- Rat
Is Toxin :
No
Purity :
Affinity purified on immobilized antigen.
UNSPSC :
41116161
KO-Validated :
yes
Cited Application :
IP IHC ICC Whole Tissue Staining
Clone :
NA
Standard quality control of each lot :
Western blot analysis
Antigen preadsorption control :
1 µg peptide per 1 µg antibody
Application Dilutions: Immunohistochemis ... :
Contact Alomone for information
Application Dilutions: Western blot wb :
1:200
more info or order :
company information
Alomone Labs
Jerusalem BioPark (JBP), Hadassah Ein Kerem
P.O. Box 4287
Jerusalem 9104201
info@alomone.com
http://www.alomone.com
972 2 531 8002
headquarters: Israel