| Published Application/Species/Sample/Dilution | Reference |
|---|
- western blot; mouse; 1:200; loading ...; fig 2d
| Dai W, Laforest B, Tyan L, Shen K, Nadadur R, Alvarado F, et al. A calcium transport mechanism for atrial fibrillation in Tbx5-mutant mice. elife. 2019;8: pubmed publisher |
- western blot; mouse; loading ...; fig 2b
| Hu J, Gao C, Wei C, Xue Y, Shao C, Hao Y, et al. RBFox2-miR-34a-Jph2 axis contributes to cardiac decompensation during heart failure. Proc Natl Acad Sci U S A. 2019;116:6172-6180 pubmed publisher |
- western blot; mouse; loading ...; fig 1b
| Guo A, Wang Y, Chen B, Wang Y, Yuan J, Zhang L, et al. E-C coupling structural protein junctophilin-2 encodes a stress-adaptive transcription regulator. Science. 2018;362: pubmed publisher |
- immunocytochemistry; human; 1:100; loading ...; fig 4a
- western blot; human; 1:1000; loading ...; fig 7a
| Hu Z, Wang J, Yu D, Soon J, de Kleijn D, Foo R, et al. Aberrant Splicing Promotes Proteasomal Degradation of L-type CaV1.2 Calcium Channels by Competitive Binding for CaVβ Subunits in Cardiac Hypertrophy. Sci Rep. 2016;6:35247 pubmed publisher |
- western blot; human; 1:500; loading ...; fig 2c
| Helms A, Alvarado F, Yob J, Tang V, Pagani F, Russell M, et al. Genotype-Dependent and -Independent Calcium Signaling Dysregulation in Human Hypertrophic Cardiomyopathy. Circulation. 2016;134:1738-1748 pubmed |
- immunohistochemistry - paraffin section; guinea pig; 1:50; fig 6
| Reyes García J, Flores Soto E, Solís Chagoyán H, Sommer B, Díaz Hernández V, García Hernández L, et al. Tumor Necrosis Factor Alpha Inhibits L-Type Ca(2+) Channels in Sensitized Guinea Pig Airway Smooth Muscle through ERK 1/2 Pathway. Mediators Inflamm. 2016;2016:5972302 pubmed publisher |
| Casas M, Murray K, Hino K, Vierra N, Sim xf3 S, Trimmer J, et al. NPC1-dependent alterations in KV2.1-CaV1.2 nanodomains drive neuronal death in models of Niemann-Pick Type C disease. Nat Commun. 2023;14:4553 pubmed publisher |
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| Liu D, Yang M, Yao Y, He S, Wang Y, Cao Z, et al. Cardiac Fibroblasts Promote Ferroptosis in Atrial Fibrillation by Secreting Exo-miR-23a-3p Targeting SLC7A11. Oxid Med Cell Longev. 2022;2022:3961495 pubmed publisher |
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| Fang Y, Li Q, Li X, Luo G, Kuang S, Luo X, et al. Piezo1 Participated in Decreased L-Type Calcium Current Induced by High Hydrostatic Pressure via. CaM/Src/Pitx2 Activation in Atrial Myocytes. Front Cardiovasc Med. 2022;9:842885 pubmed publisher |
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| Alarcón Martínez L, Shiga Y, Villafranca Baughman D, Belforte N, Quintero H, Dotigny F, et al. Pericyte dysfunction and loss of interpericyte tunneling nanotubes promote neurovascular deficits in glaucoma. Proc Natl Acad Sci U S A. 2022;119: pubmed publisher |
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| Lee S, Yeh P, Yeh H. L-Type Calcium Channels Contribute to Ethanol-Induced Aberrant Tangential Migration of Primordial Cortical GABAergic Interneurons in the Embryonic Medial Prefrontal Cortex. Eneuro. 2022;9: pubmed publisher |
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| Li J, Agvanian S, Zhou K, Shaw R, Hong T. Exogenous Cardiac Bridging Integrator 1 Benefits Mouse Hearts With Pre-existing Pressure Overload-Induced Heart Failure. Front Physiol. 2020;11:708 pubmed publisher |
| Li B, He X, Dong Z, Xuan K, Sun W, Gao L, et al. Ionomycin ameliorates hypophosphatasia via rescuing alkaline phosphatase deficiency-mediated L-type Ca2+ channel internalization in mesenchymal stem cells. Bone Res. 2020;8:19 pubmed publisher |
| Yang H, Lin F, Yang H, Yu P, Huang S, Chen Y, et al. The effect of Sirt1 deficiency on Ca2+ and Na+ regulation in mouse ventricular myocytes. J Cell Mol Med. 2020;24:6762-6772 pubmed publisher |
| Li J, Wang S, Zhang J, Liu Y, Zheng X, Ding F, et al. The CaMKII phosphorylation site Thr1604 in the CaV1.2 channel is involved in pathological myocardial hypertrophy in rats. Channels (Austin). 2020;14:151-162 pubmed publisher |
| Zamora N, Cheli V, Santiago González D, Wan R, Paez P. Deletion of Voltage-Gated Calcium Channels in Astrocytes during Demyelination Reduces Brain Inflammation and Promotes Myelin Regeneration in Mice. J Neurosci. 2020;40:3332-3347 pubmed publisher |
| Arow M, Waldman M, Yadin D, Nudelman V, Shainberg A, Abraham N, et al. Sodium-glucose cotransporter 2 inhibitor Dapagliflozin attenuates diabetic cardiomyopathy. Cardiovasc Diabetol. 2020;19:7 pubmed publisher |
| Li Q, Zhu Z, Lu J, Chao Y, Zhou X, Huang Y, et al. Sleep deprivation of rats increases postsurgical expression and activity of L-type calcium channel in the dorsal root ganglion and slows recovery from postsurgical pain. Acta Neuropathol Commun. 2019;7:217 pubmed publisher |
| An S, Gilani N, Huang Y, Muncan A, Zhang Y, Tang Y, et al. Adverse transverse-tubule remodeling in a rat model of heart failure is attenuated with low-dose triiodothyronine treatment. Mol Med. 2019;25:53 pubmed publisher |
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| Cheng W, Kao Y, Chen Y, Lin Y, Chen S, Chen Y. Macrophage migration inhibitory factor increases atrial arrhythmogenesis through CD74 signaling. Transl Res. 2020;216:43-56 pubmed publisher |
| Cacheux M, Fauconnier J, Thireau J, Osseni A, Brocard J, Roux Buisson N, et al. Interplay between Triadin and Calsequestrin in the Pathogenesis of CPVT in the Mouse. Mol Ther. 2020;28:171-179 pubmed publisher |
| Atsuta Y, Tomizawa R, Levin M, Tabin C. L-type voltage-gated Ca2+ channel CaV1.2 regulates chondrogenesis during limb development. Proc Natl Acad Sci U S A. 2019;116:21592-21601 pubmed publisher |
| Van Opbergen C, Noorman M, Pfenniger A, Copier J, Vermij S, Li Z, et al. Plakophilin-2 Haploinsufficiency Causes Calcium Handling Deficits and Modulates the Cardiac Response Towards Stress. Int J Mol Sci. 2019;20: pubmed publisher |
| Arrojo e Drigo R, Jacob S, García Prieto C, Zheng X, Fukuda M, Nhu H, et al. Structural basis for delta cell paracrine regulation in pancreatic islets. Nat Commun. 2019;10:3700 pubmed publisher |
| Chen L, Zhang B, Yang L, Bai Y, Song J, Ge Y, et al. BMAL1 Disrupted Intrinsic Diurnal Oscillation in Rat Cerebrovascular Contractility of Simulated Microgravity Rats by Altering Circadian Regulation of miR-103/CaV1.2 Signal Pathway. Int J Mol Sci. 2019;20: pubmed publisher |
| Morgenstern T, Park J, Fan Q, Colecraft H. A potent voltage-gated calcium channel inhibitor engineered from a nanobody targeted to auxiliary CaVβ subunits. elife. 2019;8: pubmed publisher |
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| Ikeda S, Matsushima S, Okabe K, Ikeda M, Ishikita A, Tadokoro T, et al. Blockade of L-type Ca2+ channel attenuates doxorubicin-induced cardiomyopathy via suppression of CaMKII-NF-κB pathway. Sci Rep. 2019;9:9850 pubmed publisher |
| Wang X, Zhuo X, Gao J, Liu H, Lin F, Ma A. Neuregulin-1β Partially Improves Cardiac Function in Volume-Overload Heart Failure Through Regulation of Abnormal Calcium Handling. Front Pharmacol. 2019;10:616 pubmed publisher |
| Fei D, Zhang Y, Wu J, Zhang H, Liu A, He X, et al. Cav 1.2 regulates osteogenesis of bone marrow-derived mesenchymal stem cells via canonical Wnt pathway in age-related osteoporosis. Aging Cell. 2019;18:e12967 pubmed publisher |
| Lai Y, Zhu B, Sun F, Luo D, Ma Y, Luo B, et al. Estrogen receptor α promotes Cav1.2 ubiquitination and degradation in neuronal cells and in APP/PS1 mice. Aging Cell. 2019;18:e12961 pubmed publisher |
| Machuki J, Zhang H, Geng J, Fu L, Adzika G, Wu L, et al. Estrogen regulation of cardiac cAMP-L-type Ca2+ channel pathway modulates sex differences in basal contraction and responses to β2AR-mediated stress in left ventricular apical myocytes. Cell Commun Signal. 2019;17:34 pubmed publisher |
| Zhang D, Hu X, Li J, Liu J, Baks Te Bulte L, Wiersma M, et al. DNA damage-induced PARP1 activation confers cardiomyocyte dysfunction through NAD+ depletion in experimental atrial fibrillation. Nat Commun. 2019;10:1307 pubmed publisher |
| Herzog K, IJlst L, van Cruchten A, van Roermund C, Kulik W, Wanders R, et al. An UPLC-MS/MS Assay to Measure Glutathione as Marker for Oxidative Stress in Cultured Cells. Metabolites. 2019;9: pubmed publisher |
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| Chung Y, Luo A, Park K, Loonat A, Lakhal Littleton S, Robbins P, et al. Iron-deficiency anemia reduces cardiac contraction by downregulating RyR2 channels and suppressing SERCA pump activity. JCI Insight. 2019;4: pubmed publisher |
| Hamilton S, Polina I, Terentyeva R, Bronk P, Kim T, Roder K, et al. PKA phosphorylation underlies functional recruitment of sarcolemmal SK2 channels in ventricular myocytes from hypertrophic hearts. J Physiol. 2020;598:2847-2873 pubmed publisher |
| Guan Y, Gao X, Tang Q, Huang L, Gao S, Yu S, et al. Nucleoporin 107 facilitates the nuclear export of Scn5a mRNA to regulate cardiac bioelectricity. J Cell Mol Med. 2019;23:1448-1457 pubmed publisher |
| Brandenburg S, Pawlowitz J, Fakuade F, Kownatzki Danger D, Kohl T, Mitronova G, et al. Axial Tubule Junctions Activate Atrial Ca2+ Release Across Species. Front Physiol. 2018;9:1227 pubmed publisher |
| Basheer W, Fu Y, Shimura D, Xiao S, Agvanian S, Hernandez D, et al. Stress response protein GJA1-20k promotes mitochondrial biogenesis, metabolic quiescence, and cardioprotection against ischemia/reperfusion injury. JCI Insight. 2018;3: pubmed publisher |
| Liang D, Wu Y, Zhou L, Chen Y, Liu H, Xie D, et al. LRP5 controls cardiac QT interval by modulating the metabolic homeostasis of L-type calcium channel. Int J Cardiol. 2019;275:120-128 pubmed publisher |
| Wright P, Sanchez Alonso J, Lucarelli C, Alvarez Laviada A, Poulet C, Bello S, et al. Partial Mechanical Unloading of the Heart Disrupts L-Type Calcium Channel and Beta-Adrenoceptor Signaling Microdomains. Front Physiol. 2018;9:1302 pubmed publisher |
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| Ednie A, Deng W, Yip K, Bennett E. Reduced myocyte complex N-glycosylation causes dilated cardiomyopathy. FASEB J. 2019;33:1248-1261 pubmed publisher |
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| Ikeda Y, Zabbarova I, Birder L, Wipf P, Getchell S, Tyagi P, et al. Relaxin-2 therapy reverses radiation-induced fibrosis and restores bladder function in mice. Neurourol Urodyn. 2018;37:2441-2451 pubmed publisher |
| Kamijo S, Ishii Y, Horigane S, Suzuki K, Ohkura M, Nakai J, et al. A Critical Neurodevelopmental Role for L-Type Voltage-Gated Calcium Channels in Neurite Extension and Radial Migration. J Neurosci. 2018;38:5551-5566 pubmed publisher |
| Michels S, Ganjam G, Martins H, Schratt G, Wohr M, Schwarting R, et al. Downregulation of the psychiatric susceptibility gene Cacna1c promotes mitochondrial resilience to oxidative stress in neuronal cells. Cell Death Discov. 2018;4:54 pubmed publisher |
| Kisko T, Braun M, Michels S, Witt S, Rietschel M, Culmsee C, et al. Cacna1c haploinsufficiency leads to pro-social 50-kHz ultrasonic communication deficits in rats. Dis Model Mech. 2018;11: pubmed publisher |
| Briot J, Mailhot O, Bourdin B, Tétreault M, Najmanovich R, Parent L. A three-way inter-molecular network accounts for the CaVα2δ1-induced functional modulation of the pore-forming CaV1.2 subunit. J Biol Chem. 2018;293:7176-7188 pubmed publisher |
| Xia P, Li L, Qi R, Shi J, Ju W, Chen M. Electrical and histological remodeling of the pulmonary vein in 2K1C hypertensive rats: Indication of initiation and maintenance of atrial fibrillation. Anatol J Cardiol. 2018;19:169-175 pubmed publisher |
| Bi C, Tham D, Perronnet C, Joshi B, Nabi I, Moukhles H. The Oxidative Stress-Induced Increase in the Membrane Expression of the Water-Permeable Channel Aquaporin-4 in Astrocytes Is Regulated by Caveolin-1 Phosphorylation. Front Cell Neurosci. 2017;11:412 pubmed publisher |
| Dong L, Cheng X, Zhou L, Hu Y. Calcium channels are involved in EphB/ephrinB reverse signaling?induced apoptosis in a rat chronic ocular hypertension model. Mol Med Rep. 2017;: pubmed publisher |
| Chen X, Weber C, Farrell E, Alvarado F, Zhao Y, Gomez A, et al. Sorcin ablation plus β-adrenergic stimulation generate an arrhythmogenic substrate in mouse ventricular myocytes. J Mol Cell Cardiol. 2018;114:199-210 pubmed publisher |
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| Sahu G, Asmara H, Zhang F, Zamponi G, Turner R. Activity-Dependent Facilitation of CaV1.3 Calcium Channels Promotes KCa3.1 Activation in Hippocampal Neurons. J Neurosci. 2017;37:11255-11270 pubmed publisher |
| Bourdin B, Briot J, Tétreault M, Sauve R, Parent L. Negatively charged residues in the first extracellular loop of the L-type CaV1.2 channel anchor the interaction with the CaV?2?1 auxiliary subunit. J Biol Chem. 2017;292:17236-17249 pubmed publisher |
| Hermosilla T, Encina M, Morales D, Moreno C, Conejeros C, Alfaro Valdés H, et al. Prolonged AT1R activation induces CaV1.2 channel internalization in rat cardiomyocytes. Sci Rep. 2017;7:10131 pubmed publisher |
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| Buonarati O, Henderson P, Murphy G, Horne M, Hell J. Proteolytic processing of the L-type Ca 2+ channel alpha 11.2 subunit in neurons. F1000Res. 2017;6:1166 pubmed publisher |
| Cerrone M, Montnach J, Lin X, Zhao Y, Zhang M, Agullo Pascual E, et al. Plakophilin-2 is required for transcription of genes that control calcium cycling and cardiac rhythm. Nat Commun. 2017;8:106 pubmed publisher |
| Espinal Enríquez J, Priego Espinosa D, Darszon A, Beltrán C, Martínez Mekler G. Network model predicts that CatSper is the main Ca2+ channel in the regulation of sea urchin sperm motility. Sci Rep. 2017;7:4236 pubmed publisher |
| Feridooni H, Kane A, Ayaz O, Boroumandi A, Polidovitch N, Tsushima R, et al. The impact of age and frailty on ventricular structure and function in C57BL/6J mice. J Physiol. 2017;595:3721-3742 pubmed publisher |
| Segura E, Bourdin B, Tétreault M, Briot J, Allen B, Mayer G, et al. Proteolytic cleavage of the hydrophobic domain in the CaV?2?1 subunit improves assembly and activity of cardiac CaV1.2 channels. J Biol Chem. 2017;292:11109-11124 pubmed publisher |
| Liu X, Shen Y, Xie J, Bao H, Cao Q, Wan R, et al. A mutation in the CACNA1C gene leads to early repolarization syndrome with incomplete penetrance: A Chinese family study. PLoS ONE. 2017;12:e0177532 pubmed publisher |
| Røe A, Aronsen J, Skårdal K, Hamdani N, Linke W, Danielsen H, et al. Increased passive stiffness promotes diastolic dysfunction despite improved Ca2+ handling during left ventricular concentric hypertrophy. Cardiovasc Res. 2017;113:1161-1172 pubmed publisher |
| Ma Y, Wang J, Bai Y, Liu M, Xie M, Dai Z. Salidroside contributes to reducing blood pressure and alleviating cerebrovascular contractile activity in diabetic Goto-Kakizaki Rats by inhibition of L-type calcium channel in smooth muscle cells. BMC Pharmacol Toxicol. 2017;18:30 pubmed publisher |
| Varodayan F, de Guglielmo G, Logrip M, George O, Roberto M. Alcohol Dependence Disrupts Amygdalar L-Type Voltage-Gated Calcium Channel Mechanisms. J Neurosci. 2017;37:4593-4603 pubmed publisher |
| Kashihara T, Nakada T, Kojima K, Takeshita T, Yamada M. Angiotensin II activates CaV 1.2 Ca2+ channels through ?-arrestin2 and casein kinase 2 in mouse immature cardiomyocytes. J Physiol. 2017;595:4207-4225 pubmed publisher |
| Bavley C, Fischer D, Rizzo B, Rajadhyaksha A. Cav1.2 channels mediate persistent chronic stress-induced behavioral deficits that are associated with prefrontal cortex activation of the p25/Cdk5-glucocorticoid receptor pathway. Neurobiol Stress. 2017;7:27-37 pubmed publisher |
| Oz S, Pankonien I, Belkacemi A, Flockerzi V, Klussmann E, Haase H, et al. Protein kinase A regulates C-terminally truncated CaV 1.2 in Xenopus oocytes: roles of N- and C-termini of the ?1C subunit. J Physiol. 2017;595:3181-3202 pubmed publisher |
| Jeong M, Kim H, Pyun J, Choi K, Lee D, Solhjoo S, et al. Cdon deficiency causes cardiac remodeling through hyperactivation of WNT/β-catenin signaling. Proc Natl Acad Sci U S A. 2017;114:E1345-E1354 pubmed publisher |
| Bond R, Bryant S, Watson J, Hancox J, Orchard C, James A. Reduced density and altered regulation of rat atrial L-type Ca2+ current in heart failure. Am J Physiol Heart Circ Physiol. 2017;312:H384-H391 pubmed publisher |
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| Philippart F, Destreel G, Merino Sepúlveda P, Henny P, Engel D, Seutin V. Differential Somatic Ca2+ Channel Profile in Midbrain Dopaminergic Neurons. J Neurosci. 2016;36:7234-45 pubmed publisher |
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| Forostyak O, Butenko O, Anderova M, Forostyak S, Sykova E, Verkhratsky A, et al. Specific profiles of ion channels and ionotropic receptors define adipose- and bone marrow derived stromal cells. Stem Cell Res. 2016;16:622-34 pubmed publisher |
| Schilling J, Horikawa Y, Zemljic Harpf A, Vincent K, Tyan L, Yu J, et al. Electrophysiology and metabolism of caveolin-3-overexpressing mice. Basic Res Cardiol. 2016;111:28 pubmed publisher |
| Fu Y, Shaw S, Naami R, Vuong C, Basheer W, Guo X, et al. Isoproterenol Promotes Rapid Ryanodine Receptor Movement to Bridging Integrator 1 (BIN1)-Organized Dyads. Circulation. 2016;133:388-97 pubmed publisher |
| Walton R, Jones S, Rostron K, Kayani A, Close G, McArdle A, et al. Interactions of Short-Term and Chronic Treadmill Training With Aging of the Left Ventricle of the Heart. J Gerontol A Biol Sci Med Sci. 2016;71:1005-13 pubmed publisher |
