Anti-BMPR1A (extracellular) Antibody | Alomone Labs ABR-043 product information

product summary

company name :

Alomone Labs

product type :

antibody

product name :

Anti-BMPR1A (extracellular) Antibody

catalog :

ABR-043

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry

more info or order :

Alomone Labs product webpage

image

image 1 :

Western blot analysis of rat colon lysate (lanes 1 and 3) and rat small intestine lysate (lanes 2 and 4):

image 2 :

Western blot analysis of mouse brain lysate:

image 3 :

Western blot analysis of human HT-29 colorectal adenocarcinoma cell line lysate (lanes 1 and 3) and human SW403 colorectal adenocarcinoma cell line lysate (lanes 2 and 4):

product information

CAT :

ABR-043

SKU :

ABR-043-CF_0.2 ml

Product Name :

Anti-BMPR1A (extracellular) Antibody

Group Type :

Antibodies

Product Type :

Antibodies

Clonality :

Polyclonal

Accession :

P36895

Applications :

IFC IHC LCI WB

Reactivity :

Human Rat Mouse

Host :

Rabbit

Blocking Peptide :

BLP-BR043

Homology :

Rat, Human - 15 out of 16 amino acid residues identical

Formulation :

PBS pH7.4

isotype :

Rabbit IgG

Peptide confirmation :

Confirmed by amino acid analysis and mass spectrometry

Reconstitution :

0.2 ml double distilled water (DDW).

Antibody Concentration After Reconstitut ... :

1 mg/ml

Storage After Reconstitution :

The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

Preservative :

No Preservative

Immunogen Location :

Extracellular, N-terminus.

Label :

Unconjugated

Storage Before Reconstitution :

The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Shipping and storage :

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

immunogen source species :

Mouse

Sequence :

(C)DSMLHGTGMKSDLDQK, corresponding to amino acid residues 27 - 42 of mouse BMPR1A

Product Page - Scientific background :

Bone morphogenic protein receptor type 1A (BMPR1A), also known as activin receptor-like kinase 3 (ALK3), and CD292, is a type I receptor within the Transforming Growth Factor-beta (TGF-β) receptor superfamily.1The TGF-β family of ligands has 33 human members, encoding TGF-β isoforms, bone morphogenetic proteins (BMPs), growth and differentiation factors (GDFs), activins, inhibins, nodal, and anti-Müllerian hormone (AMH). The TGF-β superfamily ligands regulate cellular function through seven type I TGF-β superfamily receptors (ALK (Activin like kinase)-1-7) and five type II TGF-β superfamily receptors (TβRII, ActRII, ActRIIB, AMHRII, and BMPRII). Type I (RI) and type II (RII) TGF-β superfamily receptors are serine/threonine kinases that form a complex together, and upon ligand binding the type II receptor phosphorylates the type I receptor to induce downstream signalling.1BMPR1A binds several of the TGF-β family ligands including BMP2, BMP4, GDF5, and GDF6, and is expressed in various tissues throughout the body, reflecting its diverse roles in development and homeostasis. BMPR1A has crucial roles in various biological processes, including embryonic development, organogenesis, and tissue homeostasis as well as roles in pathological conditions including heart disease, cancer and vascular calcification.1-4BMPR1A is expressed in the brain and spinal cord where it plays a role in neurogenesis, synaptic plasticity, axon guidance, and other processes related to neural development and function, as well as control of energy balance and appetite regulation.5BMPR1A is present in the immune system where it is involved in the regulation of hematopoiesis and the differentiation of immune cells, as well as regulation of inflammation and immune evasion mechanisms in certain cancers.6

Applications may also work in :

IFC IHC LCI WB

Supplier :

Alomone Labs

Target :

Bone Morphogenetic Protein Receptor Type-1A, Activin Receptor-Like Kinase 3, ALK3, Serine/Threonine-Protein Kinase Receptor R5, SKR5, CD292

Short Description :

A Rabbit Polyclonal antibody to BMPR1A (extracellular)

Long Description :

Anti-BMPR1A (extracellular) Antibody (#ABR-043) is a highly specific antibody directed against an extracellular epitope of the mouse protein. The antibody can be used in western blot, immunohistochemistry and flow cytometry applications. It has been designed to recognize BMPR1A from mouse, rat and human samples.

Negative Control :

BLP-BR043

Positive Control :

Synonyms :

Bone Morphogenetic Protein Receptor Type-1A, Activin Receptor-Like Kinase 3, ALK3, Serine/Threonine-Protein Kinase Receptor R5, SKR5, CD292

Lead Time :

1-2 Business Days

Country of origin :

Israel/IL

Applications key :

CBE- Cell-based ELISA, FC- Flow cytometry, ICC- Immunocytochemistry, IE- Indirect ELISA, IF- Immunofluorescence, IFC- Indirect flow cytometry, IHC- Immunohistochemistry, IP- Immunoprecipitation, LCI- Live cell imaging, N- Neutralization, WB- Western blot

Specifictiy :

BMPR1A

Form :

Lyophilized powder. Reconstituted antibody contains phosphate buffered saline (PBS), pH 7.4.

Comment :

Contact Alomone Labs for technical support and product customization

Species reactivity key :

H- Human, M- Mouse, R- Rat

Is Toxin :

Purity :

Affinity purified on immobilized antigen.

UNSPSC :

41116161

Clone :

Standard quality control of each lot :

Western blot analysis

Antigen preadsorption control :

1 µg peptide per 1 µg antibody

Application Dilutions: Immunohistochemis ... :

1:300

Application Dilutions: Western blot wb :

1:200

more info or order :

Alomone Labs product webpage