Anti-ACVRL1 (extracellular) Antibody | Alomone Labs ABR-041 product information

product summary

company name :

Alomone Labs

product type :

antibody

product name :

Anti-ACVRL1 (extracellular) Antibody

catalog :

ABR-041

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

mouse, rat

application :

western blot

more info or order :

Alomone Labs product webpage

image

image 1 :

Western blot analysis of rat brain membranes (lanes 1 and 3) and mouse brain membranes (lanes 2 and 4):

image 2 :

Western blot analysis of rat heart membranes:

image 3 :

Western blot analysis of Mouse endothelial MS1 cell line lysate (lanes 1 and 4), rat aortic endothelial cell line (RAEC) lysates (lanes 2 and 5) and mouse J774 macrophage cell line lysates (lanes 3 and 6):

product information

CAT :

ABR-041

SKU :

ABR-041-CF_0.2 ml

Product Name :

Anti-ACVRL1 (extracellular) Antibody

Group Type :

Antibodies

Product Type :

Antibodies

Clonality :

Polyclonal

Accession :

Q61288

Applications :

IFC LCI WB

Reactivity :

Rat Mouse

Host :

Rabbit

Blocking Peptide :

BLP-BR041

Homology :

Mouse, rat - 14/15 identical. The antibody will not work with human samples.

Formulation :

PBS pH7.4

isotype :

Rabbit IgG

Peptide confirmation :

Confirmed by amino acid analysis and mass spectrometry

Reconstitution :

0.2 ml double distilled water (DDW).

Antibody Concentration After Reconstitut ... :

1 mg/ml

Storage After Reconstitution :

The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

Preservative :

No Preservative

Immunogen Location :

Extracellular, N-terminus.

Label :

Unconjugated

Storage Before Reconstitution :

The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Shipping and storage :

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

immunogen source species :

Mouse

Sequence :

CYRSF(S)NHNVSLMLE, corresponding to amino acid residues 89 - 103 of mouse ACVRL1

Product Page - Scientific background :

ACVRL1, commonly known as Activin Receptor-Like Kinase 1 (ALK1), is a type I receptor in the Transforming Growth Factor-beta (TGF-β) superfamily. This receptor belongs to a family of serine/threonine kinase receptors, which form heteromeric complexes with type II receptors to transduce signals via SMAD transcription factors. ALK1 specifically interacts with Bone Morphogenetic Proteins (BMPs), particularly BMP9 and BMP10, to activate SMAD1/5/8 phosphorylation, regulating endothelial cell proliferation, maturation and migration1-5. ALK1 is primarily expressed in endothelial cells and vascular tissues, where it maintains vascular integrity. Dysregulation or mutations in ACVRL1 – the gene ALK1 - are implicated in Hereditary Hemorrhagic Telangiectasia type 2 (HHT2), which is characterized by vascular malformations and arteriovenous malformations (AVMs)2-5. Pulmonary arterial hypertension (PAH) has also been linked to ACVRL1 mutations, further emphasizing its role in vascular biology2-3. In vitro studies have shown that ALK1 promotes endothelial cell proliferation and migration, while in vivo, it prevents AVMs and supports vascular development3-5. In cancer, ALK1 signaling influences immune cell infiltration and angiogenesis, marking it as a potential therapeutic target4.

Applications may also work in :

IFC LCI WB

Supplier :

Alomone Labs

Target :

Activin A Receptor Like Type 1, ALK1, Serine/Threonine-Protein Kinase Receptor R3, SKR3, TGF-B Superfamily Receptor Type I, TSR-I

Short Description :

A Rabbit Polyclonal Antibody to ACVRL1

Long Description :

Anti-ACVRL1 (extracellular) Antibody (#ABR-041) is a highly specific antibody directed against an extracellular epitope of the mouse protein. The antibody can be used in western blot and flow cytometry applications. It has been designed to recognize ACVRL1 from mouse and rat samples. The antibody will not work with human samples.

Negative Control :

BLP-BR041

Positive Control :

Synonyms :

Activin A Receptor Like Type 1, ALK1, Serine/Threonine-Protein Kinase Receptor R3, SKR3, TGF-B Superfamily Receptor Type I, TSR-I

Lead Time :

1-2 Business Days

Country of origin :

Israel/IL

Applications key :

CBE- Cell-based ELISA, FC- Flow cytometry, ICC- Immunocytochemistry, IE- Indirect ELISA, IF- Immunofluorescence, IFC- Indirect flow cytometry, IHC- Immunohistochemistry, IP- Immunoprecipitation, LCI- Live cell imaging, N- Neutralization, WB- Western blot

Specifictiy :

SKR3

Form :

Lyophilized powder. Reconstituted antibody contains phosphate buffered saline (PBS), pH 7.4.

Comment :

Contact Alomone Labs for technical support and product customization

Species reactivity key :

H- Human, M- Mouse, R- Rat

Is Toxin :

Purity :

Affinity purified on immobilized antigen.

UNSPSC :

41116161

Standard quality control of each lot :

Western blot analysis.

Antigen preadsorption control :

1 µg peptide per 1 µg antibody

more info or order :

Alomone Labs product webpage