17-AAG | Alomone Labs A-580 product information

product summary

company name :

Alomone Labs

product type :

chemical

product name :

17-AAG

catalog :

A-580

more info or order :

Alomone Labs product webpage

citations: 2

Reference
Fux L, Feibish N, Cohen Kaplan V, Gingis Velitski S, Feld S, Geffen C, et al. Structure-function approach identifies a COOH-terminal domain that mediates heparanase signaling. Cancer Res. 2009;69:1758-67 pubmed publisher
Teruya H, Higa F, Akamine M, Ishikawa C, Okudaira T, Tomimori K, et al. Mechanisms of Legionella pneumophila-induced interleukin-8 expression in human lung epithelial cells. BMC Microbiol. 2007;7:102 pubmed

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image 1 :

image 2 :

Alomone Labs 17-AAG inhibits growth of HeLa tumor cell lines. - Cells were treated with different concentrations of17-AAG(#A-580). The number of cells was measured using the tryphan blue method and plotted against the drug concentration.

product information

CAT :

A-580

SKU :

A-580_0.1 mg

Product Name :

17-AAG

Group Type :

Non Antibodies

Product Type :

S. Molecules

Storage After Reconstitution :

The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.

Shipping and storage :

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

Product Page - Scientific background :

17-AAG is a less toxic and more stable derivative of the antibiotic Geldanamycin. It binds to Hsp90 and regulates its function.1 Hsp90 regulates the physiology of cells exposed to environmental stress and in maintaining the malignant phenotype of tumor cells. 17-AAG induces apoptosis and displays anti-tumor effects in tumor cells. 17-AAG depletes cancer cells of erbB-1, erbB-2, Raf-1, and Akt and hence inhibits the Ras/Raf/MEK and PI3-kinase signaling pathways.2,3 It also downregulates vascular endothelial growth factor (VEGF) expression.4 17AAG is currently in phase I clinical trial in several centers worldwide.5-8 Preliminary data obtained from these trials demonstrate that anti-tumor activity is achieved at concentrations below the maximum tolerated dose.9

Supplier :

Alomone Labs

Long Description :

17-AAG (#A-580) is a highly pure, semi-synthetic, and biologically active compound.

Short Description :

An Anticancer Antibiotic

MW :

585.7

Synonyms :

NSC330507, 17-(Allylamino)-17-demethoxygeldanamycin

Source :

Semi-synthetic

Molecular formula :

C31H43N3O8.

Effective Concentration :

50-100 nM.

Activity :

17-AAG is a less toxic and more stable derivative of the antibiotic Geldanamycin. It binds to Hsp90 and regulates its function and displays anti-tumor effects1-3.

Reconstitution and Solubility :

DMSO, methanol. Centrifuge all product preparations before use (10000 x g 5 min).

Solubility :

DMSO, methanol. Centrifuge all product preparations before use (10000 x g 5 min).

Storage of solutions :

Up to four weeks at 4°C or three months at -20°C.

Lead Time :

1-2 Business Days

Country of origin :

Israel/IL

Applications key :

Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.

Purity :

>99%

CAS No :

75747-14-7

Form :

Lyophilized powder.

Comment :

Contact Alomone Labs for technical support and product customization

UNSPSC :

41116134

Bioassay Tested :

Yes

Chemical Name :

17-Demethoxy-17-(2-propenylamino) geldanamycin.

more info or order :

Alomone Labs product webpage