AZD-1332 | Alomone Labs A-495 product information

product summary

company name :

Alomone Labs

product type :

chemical

product name :

AZD-1332

catalog :

A-495

more info or order :

Alomone Labs product webpage

image

image 1 :

Alomone Labs AZD-1332 inhibits NGF-mediated survival of serum-deprived PC12 cells. - Dose-response curve of AZD-1332 (#A-495) inhibition of Native mouse NGF 2.5S protein ( 95%) (#N-100) mediated survival of serum-deprived PC12 cells. Cell viability was determined by the XTT method and normalized to control. IC50was calculated at 1.9 nM.

product information

CAT :

A-495

SKU :

A-495_10 mg

Product Name :

AZD-1332

Group Type :

Non Antibodies

Product Type :

S. Molecules

Storage After Reconstitution :

The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.

Shipping and storage :

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

Product Page - Scientific background :

AZD-1332 is a potent and selective inhibitor of the Tropomyosin-related kinase (TrkA, TrkB, and TrkC) receptors. The compound is at least 30-fold more specific towards Trk in cell-based assays over a wide range of other kinases tested. AZD-1332 inhibits Trk kinase activity in cells at low nanomolar concentrations, the compound demonstrates IC50 values of

Supplier :

Alomone Labs

Target :

TrkA, TrkB, TrkC receptors

Long Description :

AZD-1332 (#A-495) is a highly pure, synthetic, and biologically active compound.

Short Description :

A Potent and Selective Inhibitor of TrkA, TrkB, TrkC Receptors

MW :

391.8

Synonyms :

AZ-23 racemate, AZ-23 compound, 5-Chloro-2-N-[1-(5-fluoropyridin-2-yl)ethyl]-4-N-(3-propan-2-yloxy-1H-pyrazol-5-yl)pyrimidine-2,4-diamine

Source :

Synthetic

Molecular formula :

C17H19ClFN7O.

Effective Concentration :

1-100 nM.

Activity :

AZD-1332 is a potent, selective, and orally bioavailable inhibitor of tyrosine kinase receptors (IC50 values of

Reconstitution and Solubility :

Soluble in DMSO. Centrifuge all products before handling (10000 x g 5 min).

Solubility :

Soluble in DMSO. Centrifuge all products before handling (10000 x g 5 min).

Storage of solutions :

Store at -20°C. It is recommended to aliquot stock solutions to prevent repeated thawing and freezing.

Lead Time :

1-2 Business Days

Country of origin :

Israel/IL

Applications key :

Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.

Purity :

>95%

CID :

49831044

Form :

Lyophilized Powder

Comment :

Contact Alomone Labs for technical support and product customization

UNSPSC :

41116134

Bioassay Tested :

Yes

Chemical Name :

5-chloro-2-N-[1-(5-fluoropyridin-2-yl)ethyl]-4-N-(3-propan-2-yloxy-1H-pyrazol-5-yl)pyrimidine-2,4-diamine.

more info or order :

Alomone Labs product webpage