ATPA | Alomone Labs A-480 product information

product summary

company name :

Alomone Labs

product type :

chemical

product name :

ATPA

catalog :

A-480

more info or order :

Alomone Labs product webpage

image

image 1 :

Alomone Labs RQ 00203078 inhibits TRPM8 channels expressed in HEK-293 cells. - Dose response curve of TRPM8 inhibition byRQ 00203078(#R-170) showing full inhibition at 1 M. Cells were loaded with Calcium-5 dye incubated for 10 min with increasing concentrations of RQ 00203078 and activated by 30 nM Icilin. Changes in intracellular Ca2+following activator application were detected as changes in 485 nm/525 nm fluorescence (RFU).

product information

CAT :

A-480

SKU :

A-480_10 mg

Product Name :

ATPA

Group Type :

Non Antibodies

Product Type :

S. Molecules

Storage After Reconstitution :

The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.

Shipping and storage :

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

Product Page - Scientific background :

ATPA, an AMPA derivative, is a potent and selective agonist of the GluR5 (GluK1) kainate receptor subtype, with an EC50 value of 0.66 µM1. ATPA is less active towards other kainate receptor subtypes and is inactive towards GluR6. The compound also shows weak agonistic activities towards AMPA receptors1,2. Studies show that ATPA can induce clonic seizures when infused intravenously or directly into the rat amygdala3.GluR5 containing kainate receptors play an important role in the regulation of GABA(A) receptor-mediated inhibitory transmission in the hippocampus and in the amygdala3.

Supplier :

Alomone Labs

Target :

GluK1 (GluR5) kainate receptors

Long Description :

ATPA (#A-480) is a highly pure, synthetic, and biologically active compound.

Short Description :

A Potent and Selective Agonist of GluK1 Kainate Receptor

MW :

228.25

Source :

Synthetic

Molecular formula :

C10H16N2O4.

Effective Concentration :

0.5-50 µM.

Activity :

ATPA is a potent and selective agonist of GluR5 kainate receptor (EC50 = 0.66 µM), inactive on GluR6 and less active on other kainate receptor subtypes. It is also a significantly weaker agonist of AMPA receptors (EC50 = 8 µM-62 µM, depending on subtype)1,2.

Reconstitution and Solubility :

Soluble in water, DMSO and 1eq NaOH. Centrifuge all products before handling (10000 x g 5 min).

Solubility :

Soluble in water, DMSO and 1eq NaOH. Centrifuge all products before handling (10000 x g 5 min).

Storage of solutions :

Store at -20°C. It is recommended to prepare solutions afresh on the day of use, or aliquot stock solutions stored at -20°C to prevent repeated thawing and freezing.

Lead Time :

1-2 Business Days

Country of origin :

Israel/IL

Applications key :

Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.

Purity :

>96%

CAS No :

140158-50-5

Form :

Lyophilized Powder

Comment :

Contact Alomone Labs for technical support and product customization

UNSPSC :

41116134

Bioassay Tested :

Yes

Chemical Name :

2-azaniumyl-3-(5-tert-butyl-3-oxo-1,2-oxazol-4-yl)propanoate.

more info or order :

Alomone Labs product webpage