chemical

Atrasentan

A-455

A-455_1 mg

Atrasentan

Non Antibodies

S. Molecules

The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

Atrasentan (A-127722) is a synthetic compound that acts as a potent and selective antagonist of endothelin A (ET-A) receptor. Atrasentan is highly selective towards ET-A receptor, exhibiting 1000-fold selectivity over ET-B receptors1. It inhibits endothelin-1 radioligand binding with an IC50 value of 0.36 nM and endothelin-1-stimulated phosphoinositol hydrolysis with an IC50 of 0.16 nM1.ET-A receptors are predominantly detected in peripheral tissues, especially in vascular smooth muscle tissues where they mediate vasoconstriction. They are also expressed in several regions of the brain. The ET-A receptor has high affinity for endothelin-1 and endothelin-2 and relatively low affinity for endothelin-3, while the ET-B receptor has high affinity for all endothelin isopeptides2.

Alomone Labs

ET-A receptors

Atrasentan (#A-455) is a highly pure, synthetic, and biologically active compound.

A Potent and Selective Antagonist of Endothelin A Receptors

510.62

(+)-A-127722, A-147627, ABT-627

Synthetic

C29H38N2O6.

0.01-10 nM.

Atrasentan is a potent and highly selective antagonist of ET-A endothelin receptors, exhibiting a 1000-fold selectivity for ET-A over ET-B receptors, inhibiting endothelin-1 radioligand binding with an IC50 of 0.36 nM and endothelin-1-stimulated phosphoinositol hydrolysis with IC50 of 0.16 nM1.

Soluble in DMSO. Centrifuge all products before use (10000 x g 5 min).

Soluble in DMSO. Centrifuge all products before use (10000 x g 5 min).

Up to three months at -20°C.

1-2 Business Days

Israel/IL

Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.

>98%

173937-91-2

Lyophilized powder.

Contact Alomone Labs for technical support and product customization

41116134

Yes

(2R,3R,4S)-4-(1,3-benzodioxol-5-yl)-1-[2-(dibutylamino)-2-oxoethyl]-2-(4-methoxyphenyl)pyrrolidine-3-carboxylic acid.