ACT-462206 | Alomone Labs A-450 product information

product summary

company name :

Alomone Labs

product type :

chemical

product name :

ACT-462206

catalog :

A-450

more info or order :

Alomone Labs product webpage

image

image 1 :

ManufacturerBioassayAlomone Labs ACT-462206 inhibits human OX1 receptors expressed in CHO-K1 cells. - Dose response curve of the normalized inhibition of hOX1 receptor activity by ACT-462206 (#A-450). Cells were loaded with Fluo-8 dye, incubated with increasing concentrations of ACT-462206, and stimulated with 15 nM Orexin-A. Changes in intracellular Ca2+ following agonist application were detected as changes in maximum relative fluorescence (RLU) using FLIPRTETRA™. IC50 was calculated at 293.4 nM.

product information

CAT :

A-450

SKU :

A-450_10 mg

Product Name :

ACT-462206

Group Type :

Non Antibodies

Product Type :

S. Molecules

Storage After Reconstitution :

The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.

Shipping and storage :

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

Product Page - Scientific background :

ACT-462206 is a potent, brain-penetrant dual orexin 1/orexin 2 receptor antagonist with IC50 values of 60 nM and 11 nM, respectively. It has been subjected to clinical trials for use as a sleep inducer1.Orexins are highly conserved proteins known to control feeding behavior, sleep-wake rhythm, reward and addiction, and energy balance. In addition, several reports show that orexin/receptor pathways are involved in pathological processes of neurological diseases such as narcolepsy, depression, ischemic stroke, drug addiction and Alzheimer's disease2.

Supplier :

Alomone Labs

Target :

OX1, OX2 orexin receptors

Long Description :

ACT-462206 (#A-450) is a highly pure, synthetic, and biologically active compound.

Short Description :

A Potent Antagonist of Orexin1/2 Receptors

MW :

388.48

Synonyms :

(2S)-N-(3,5-Dimethylphenyl)-1-[(4-methoxyphenyl)sulfonyl]-2-pyrrolidinecarboxamide

Source :

Synthetic

Molecular formula :

C20H24N2O4S

Effective Concentration :

100 nM - 5 µM

Activity :

ACT-462206 is a potent and selective dual orexin receptor antagonist (IC50 of 60 nM and 11 nM on orexin 1 and 2 receptors, respectively). ACT-462206 is brain penetrant and orally bioavailable, demonstrating anxiolytic-like properties in rodents without affecting cognition and motor function1.

Reconstitution and Solubility :

Soluble up to 100 mM in DMSO. Spin down all products before handling.

Solubility :

Soluble up to 100 mM in DMSO. Spin down all products before handling.

Storage of solutions :

Store at -20°C for several months. It is recommended to aliquot stock solutions to avoid repeated thawing and freezing.

Lead Time :

1-2 Business Days

Country of origin :

Israel/IL

Applications key :

Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.

Purity :

>98%

CAS No :

1361321-96-1

Form :

Powder

Comment :

Contact Alomone Labs for technical support and product customization

UNSPSC :

41116134

Bioassay Tested :

Yes

Chemical Name :

(2S)-N-(3,5-dimethylphenyl)-1-(4-methoxyphenyl)sulfonylpyrrolidine-2-carboxamide

more info or order :

Alomone Labs product webpage