A-841720 | Alomone Labs A-440 product information

product summary

company name :

Alomone Labs

product type :

chemical

product name :

A-841720

catalog :

A-440

more info or order :

Alomone Labs product webpage

image

image 1 :

Expression of CaV1.3 in rat DRGs - Immunohistochemical staining of rat dorsal root ganglion (DRG) using Guinea pig Anti-CaV1.3(CACNA1D)Antibody (#AGP-061) (1:200). A. CaV1.3 staining (red) is detected in some DRG cells (arrows). B. Nuclei staining using DAPI as the counterstain. C. Merged image of panels A and B.

product information

CAT :

A-440

SKU :

A-440_10 mg

Product Name :

A-841720

Group Type :

Non Antibodies

Product Type :

S. Molecules

Storage After Reconstitution :

Store the reconstituted solution at -20°C for the shortest time possible. Avoid multiple freeze-thaw cycles. We do not recommend storing the product in working solutions for longer than a day. Avoid exposure to light.

Shipping and storage :

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

Product Page - Scientific background :

A-841720 is a potent, non-competitive antagonist of mGluR11,2 with an IC50 of 10 nM1. At higher concentrations it also inhibits mGluR5 receptors displaying an IC50 value of 342 nM1.Glutamate is the most abundant excitatory neurotransmitter in the central nervous system. It modulates the activity of many types of synapses by activating in part metabotropic glutamate receptors (mGluRs). mGluRs consist of three groups: I, II, and III with a total of eight subtypes, mGluR1 to mGluR8. mGluR1 plays an important role in the central sensitization of pain and in a variety of functions with potential implications in neurological and psychiatric disorders1,2.

Supplier :

Alomone Labs

Target :

mGluR1, mGluR5

Long Description :

A-841720 (#A-440) is a highly pure, synthetic, and biologically active compound.

Short Description :

An Antagonist of mGluR1 and mGluR5

MW :

343.45

Source :

Synthetic

Molecular formula :

C17H21N5OS.

Effective Concentration :

1-100 nM.

Activity :

A-841720 is a potent and selective noncompetitive mGluR1 antagonist, acting on mGluR1 and mGluR5 with IC50 values of 10 nM and 342 nM, respectively1. In vivo it shows analgesic properties, significantly attenuating spontaneous post-operative pain behavior in rats (ED50 = 10 μMol/kg)2.

Reconstitution and Solubility :

Soluble in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).

Solubility :

Soluble in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).

Storage of solutions :

-20°C.

Lead Time :

1-2 Business Days

Country of origin :

Israel/IL

Applications key :

Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.

Purity :

>98%

CAS No :

869802-58-4

Form :

Lyophilized powder.

Comment :

Contact Alomone Labs for technical support and product customization

UNSPSC :

41116134

Bioassay Tested :

Yes

Chemical Name :

3-(azepan-1-yl)-9-(dimethylamino)pyrido[1,2]thieno[3,4-d]pyrimidin-4-one.

more info or order :

Alomone Labs product webpage