chemical

AZD-9056 hydrochloride

A-425

A-425_1 mg

AZD-9056 hydrochloride

Non Antibodies

S. Molecules

The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

AZD-9056 hydrochloride is an adamantane amide that acts as a potent and selective antagonist of P2X7 receptors. It inhibits YoPro1 (membrane-impermeable fluorescent dye) uptake in HEK-hP2X7 cells with IC50 value of 11.2 nM1. Studies show that treatment with AZD-9056 exerts pain-relieving and anti-inflammatory effects1,2.The P2X7 receptor is a member of the ligand-gated ion channels activated by extracellular ATP. There are seven receptor subtypes: P2X1-P2X7. P2X7 receptors participate in a variety of cellular responses such as membrane permeabilization, activation of caspases, cytokine release, cell proliferation, and apoptosis. P2X7 receptors are highly expressed throughout autonomic, sensory and central neurons and in visceral smooth muscle, immune cells and epithelia3,4.

Alomone Labs

P2X7 receptors

AZD-9056 hydrochloride (#A-425) is a highly pure, synthetic, and biologically active compound.

A Potent and Selective Antagonist of P2X7 Receptors

455.46

N-(1-Adamantylmethyl)-2-chloro-5-[3-(3-hydroxypropylamino)propyl]benzamide hydrochloride

Synthetic

C24H36Cl2N2O2 (C24H35ClN2O2 · HCl).

1-100 nM.

AZD-9056 is a potent and selective, orally bioavailable antagonist of the purinergic P2X7 receptor, shown to inhibit YoPro1 uptake in HEK-hP2X7 cells with IC50 of 11.2 nM1. AZD-9056 shows pain-relieving and anti-inflammatory effects in vivo2.

Soluble in DMSO. Centrifuge all products before handling (10000 x g 5 min).

Soluble in DMSO. Centrifuge all products before handling (10000 x g 5 min).

-20°C. It is recommended to aliquot stock solutions to prevent repeated thawing and freezing.

1-2 Business Days

Israel/IL

Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.

>97%

345303-91-5

Lyophilized Powder

Contact Alomone Labs for technical support and product customization

41116134

Yes

N-(1-adamantylmethyl)-2-chloro-5-[3-(3-hydroxypropylamino)propyl]benzamide hydrochloride.