A-740003 | Alomone Labs A-420 product information

product summary

company name :

Alomone Labs

product type :

chemical

product name :

A-740003

catalog :

A-420

more info or order :

Alomone Labs product webpage

image

image 1 :

Western blot analysis of mouse kidney lysates (lanes 1 and 3) and rat kidney membranes (lanes 2 and 4): - 12.Anti-SGLT2 (extracellular) Antibody (#AGT-032) (1:200).34. Anti-SGLT2 (extracellular) Antibody preincubated with the negative control antigen.

product information

CAT :

A-420

SKU :

A-420_10 mg

Product Name :

A-740003

Group Type :

Non Antibodies

Product Type :

S. Molecules

Storage After Reconstitution :

The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.

Shipping and storage :

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

Product Page - Scientific background :

A-740003 is a potent, selective, and competitive antagonist of the P2X7 receptor, with IC50 values of 18 nM and 44 nM for rat and human P2RX7, respectively1. The compound shows weak or no activity on other P2 receptors.A-740003 has the ability to reduce neuropathic pain and tumor growth in vivo. Systemic administration of A-740003 in rat produces dose-dependent antinociception in a spinal nerve ligation model1,2.The P2X receptor family includes seven receptor subtypes: P2X1-P2X7. P2X7 receptors participate in a variety of cellular responses such as membrane permeabilization, activation of caspases, cytokine release, cell proliferation, and apoptosis. They are highly expressed on immune cells including glial cells, macrophages and other antigen-presenting cells1,2.

Supplier :

Alomone Labs

Target :

P2X7 receptors

Long Description :

A-740003 (#A-420) is a highly pure, synthetic, and biologically active compound.

Short Description :

A Potent and Selective Antagonist of P2X7 Receptors

MW :

474.55

Synonyms :

N-(1-{[(Cyanoimino)(5-quinolinylamino)methyl]amino}-2,2-dimethylpropyl)-2-(3,4-dimethoxyphenyl)acetamide

Source :

Synthetic

Molecular formula :

C26H30N6O3.

Effective Concentration :

10 nM - 1 µM.

Activity :

A-740003 is a potent and selective competitive antagonist of P2X7 receptors with IC50 values of 18 nM, 44 nM and 0.68 µM for rat, human and mouse receptors, respectively. A-740003 reduces neuropathic pain and tumor growth in vivo1,2.

Reconstitution and Solubility :

Soluble in DMSO. Centrifuge all products before handling (10000 x g 5 min).

Solubility :

Soluble in DMSO. Centrifuge all products before handling (10000 x g 5 min).

Storage of solutions :

-20°C. It is recommended to aliquot stock solutions to prevent repeated thawing and freezing.

Lead Time :

1-2 Business Days

Country of origin :

Israel/IL

Applications key :

Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.

Purity :

>96% (HPLC)

CAS No :

861393-28-4

Form :

Lyophilized Powder

Comment :

Contact Alomone Labs for technical support and product customization

UNSPSC :

41116134

Bioassay Tested :

Yes

Chemical Name :

N-[1-[(E)-[(cyanoamino)-(quinolin-5-ylamino)methylidene]amino]-2,2-dimethylpropyl]-2-(3,4-dimethoxyphenyl)acetamide.

more info or order :

Alomone Labs product webpage