A-804598 | Alomone Labs A-415 product information

product summary

company name :

Alomone Labs

product type :

chemical

product name :

A-804598

catalog :

A-415

more info or order :

Alomone Labs product webpage

image

image 1 :

Peptide (C)KDPAVGNISST(S)YQPR corresponding to amino acid residues 242-257 of rat SGLT2 (AccessionP53792). 3rdextracellular loop.

product information

CAT :

A-415

SKU :

A-415_10 mg

Product Name :

A-804598

Group Type :

Non Antibodies

Product Type :

S. Molecules

Storage After Reconstitution :

The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.

Shipping and storage :

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

Product Page - Scientific background :

A-804598 is a potent, competitive, and selective antagonist of the P2X7 receptor. It displays IC50 values of 10 nM, 9 nM and 11 nM for rat, mouse and human P2RX7, respectively1.P2X receptors are a family of ligand-gated cation channels activated by the binding of extracellular ATP. To date, seven members of this family have been identified and shown to function as either homomeric or heteromeric combinations2. P2X7 receptors mediate the release of proinflammatory cytokines2.

Supplier :

Alomone Labs

Target :

P2X7 receptors

Long Description :

A-804598 (#A-415) is a highly pure, synthetic, and biologically active compound.

Short Description :

A Potent and Selective Antagonist of P2X7 Receptors

MW :

315.37

Synonyms :

N-Cyano-N''-[(1S)-1-phenylethyl]-N'-5-quinolinyl-guanidine

Source :

Synthetic

Molecular formula :

C19H17N5.

Effective Concentration :

1-100 nM.

Activity :

A-804598 is a potent and selective, competitive and high-affinity antagonist of the purinergic P2X7 receptor, with IC50 values of around 10 nM for mouse, rat, and human receptors1-3.

Reconstitution and Solubility :

Soluble in DMSO. Centrifuge all products before handling (10000 x g 5 min).

Solubility :

Soluble in DMSO. Centrifuge all products before handling (10000 x g 5 min).

Storage of solutions :

Store at -20°C. It is recommended to aliquot stock solutions to prevent repeated thawing and freezing.

Lead Time :

1-2 Business Days

Country of origin :

Israel/IL

Applications key :

Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.

Purity :

>99%

CAS No :

1125758-85-1

Form :

Lyophilized Powder

Comment :

Contact Alomone Labs for technical support and product customization

UNSPSC :

41116134

Bioassay Tested :

Yes

Chemical Name :

1-cyano-2-[(1S)-1-phenylethyl]-3-quinolin-5-ylguanidine.

more info or order :

Alomone Labs product webpage