chemical

AACBA hydrochloride

A-410

A-410_10 mg

AACBA hydrochloride

Non Antibodies

S. Molecules

The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

AACBA hydrochloride is a potent and selective antagonist of P2X7 receptors. It inhibits human and rat P2X7 receptors with IC50 values of 18 nM and 29 nM, respectively1.AACBA reduces interleukin-6 release in a dose-dependent manner and prevents or reverses carrageenan-induced paw edema and mechanical hypersensitivity in acute in vivo models of pain and inflammation1.P2X receptors are a family of ion channels gated by ATP, a ubiquitous energy donor and receptor ligand in living cells. P2X receptors are widely expressed in neuronal, muscular, epithelial and immune cells and play a pivotal role in models of various pain conditions. P2X7 receptor mediates the release of proinflammatory cytokines known to have roles in inflammatory/immune conditions and pain1,2.

Alomone Labs

P2X7 receptors

AACBA hydrochloride (#A-410) is a highly pure, synthetic, and biologically active compound.

A Potent and Selective Antagonist of P2X7 Receptors

438.43

N-(Adamantan-1-ylmethyl)-5-[(3R-aminopyrrolidin-1-yl)methyl]-2-chloro-benzamide hydrochloride, GSK314181A

Synthetic

C23H33Cl2N3O (C23H32ClN3O · HCl).

1-100 nM.

AACBA hydrochloride is a potent and selective antagonist of P2X7 receptors, shown to inhibit human and rat P2X7 receptors with IC50 values of 18 nM and 29 nM, respectively. Active in vivo on acute models of pain and inflammation1.

Soluble up to 200 mM in water. Centrifuge all products before handling (10000 x g 5 min).

Soluble up to 200 mM in water. Centrifuge all products before handling (10000 x g 5 min).

Store at -20°C. It is recommended to aliquot stock solutions to prevent repeated thawing and freezing.

1-2 Business Days

Israel/IL

Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.

>99%

1101868-22-7

Lyophilized Powder

Contact Alomone Labs for technical support and product customization

41116134

Yes

N-(Adamantan-1-ylmethyl)-5-[(3R-aminopyrrolidin-1-yl)methyl]-2-chloro-benzamide hydrochloride.