A-850002 | Alomone Labs A-390 product information

product summary

company name :

Alomone Labs

product type :

chemical

product name :

A-850002

catalog :

A-390

more info or order :

Alomone Labs product webpage

image

image 1 :

Alomone Labs BQ-3020 activates Endothelin B receptor-mediated Ca2+ mobilization in CHO-K1-mt Aequorin cells. - Dose-response curve of normalized activation of the Endothelin B receptor-mediated Ca2+mobilization evoked byBQ-3020(#SPE-200). Ca2+response was detected by measuring aequorin-derived fluorescence following application of BQ-3020 and Endothelin-1 at different concentrations. The EC50measured for BQ-3020 is 23 pM.

product information

CAT :

A-390

SKU :

A-390_10 mg

Product Name :

A-850002

Group Type :

Non Antibodies

Product Type :

S. Molecules

Storage After Reconstitution :

The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.

Shipping and storage :

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

Product Page - Scientific background :

A-850002 is a synthetic, selective and potent antagonist of mGluR1 receptors. It inhibits mGluR1 receptors in rat primary cerebellar granule neurons with an IC50 value of 27 nM in calcium mobilization assays and human mGluR1 receptors expressed in 1321N1 type cells with an IC50 of 43 nM1,2.Metabotropic glutamate receptors (mGluRs) are G-protein coupled receptors that play an important role in synaptic plasticity and other neuro-physiological and pathological processes including a major role in central sensitization and neuropathic pain. Type 1 mGluRs are mainly found on post-synaptic neurons and are known to affect the fate of neuronal progenitor cells, neural stem cells and the formation of the hippocampus3.

Supplier :

Alomone Labs

Target :

mGluR1 receptor

Long Description :

A-850002 (#A-390) is a highly pure, synthetic, and biologically active compound.

Short Description :

A Selective and Potent Antagonist of mGluR1 Receptors

MW :

336.41

Synonyms :

CHEMBL223869, GTPL6355, SCHEMBL6102967, BDBM50177062

Source :

Synthetic

Molecular formula :

C18H16N4OS.

Effective Concentration :

1 nM - 1 µM.

Activity :

A-850002 inhibits mGluR1 in rat primary cerebellar granule neurons with an IC50 of 27 nM1 and human mGluR1 expressed in 1321N1 cells with an IC50 of 43 nM2.

Reconstitution and Solubility :

Up to 25 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).

Solubility :

Up to 25 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).

Storage of solutions :

-20°C.

Lead Time :

1-2 Business Days

Country of origin :

Israel/IL

Applications key :

Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.

Purity :

>99%

CAS No :

869802-73-3

Form :

Lyophilized Powder

Comment :

Contact Alomone Labs for technical support and product customization

UNSPSC :

41116134

Bioassay Tested :

Yes

Chemical Name :

9-(dimethylamino)-3-(4-methylphenyl)pyrido[2,3]thieno[2,4-d]pyrimidin-4-one.

more info or order :

Alomone Labs product webpage