AF-353 | Alomone Labs A-375 product information

product summary

company name :

Alomone Labs

product type :

chemical

product name :

AF-353

catalog :

A-375

more info or order :

Alomone Labs product webpage

citations: 1

Reference
Perez Neut M, Haar L, Rao V, Santha S, Lansu K, Rana B, et al. Activation of hERG3 channel stimulates autophagy and promotes cellular senescence in melanoma. Oncotarget. 2016;7:21991-2004 pubmed publisher

product information

CAT :

A-375

SKU :

A-375_10 mg

Product Name :

AF-353

Group Type :

Non Antibodies

Product Type :

S. Molecules

Shipping and storage :

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

Product Page - Scientific background :

AF-353 is a highly potent and selective antagonist of P2X3 and P2X2/3 purinergic receptors. The compound is orally bioavailable and is being used as an in vivo tool for studying the role of P2X channels in animal pain models.P2X receptors are a family of ion channels that are gated by ATP. They are expressed in cell types of almost every origin, including neuronal, muscular, epithelial and immune and have been shown to play a pivotal role in models of various pain conditions1.Antagonism of P2X3 receptors can reduce arterial pressure and basal sympathetic activity and normalizes carotid body hyper-reflexia in rats with hypertension2.

Supplier :

Alomone Labs

Target :

P2X3 receptors

Long Description :

AF-353 (#A-375) is a highly pure, synthetic, and biologically active compound.

Short Description :

A Potent and Selective Antagonist of P2X3 Receptor

MW :

400.21

Synonyms :

RO-4

Source :

Synthetic

Molecular formula :

C14H17IN4O2.

Effective Concentration :

1 nM - 10 µM.

Activity :

AF-353 is a highly potent and selective P2X3 and P2X2/3 receptor antagonist. pIC50 for these receptors, measured using intracellular calcium assays and whole-cell voltage-clamp, range from 7.4 to 8.51.

Reconstitution and Solubility :

Up to 25mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).

Solubility :

Up to 25mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).

Storage of solutions :

-20°C.

Lead Time :

1-2 Business Days

Country of origin :

Israel/IL

Applications key :

Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.

Purity :

>95% (HPLC)

CAS No :

865305-30-2

Form :

Lyophilized powder.

Comment :

Contact Alomone Labs for technical support and product customization

UNSPSC :

41116134

Bioassay Tested :

Yes

Chemical Name :

5-(5-iodo-4-methoxy-2-propan-2-ylphenoxy)pyrimidine-2,4-diamine.

more info or order :

Alomone Labs product webpage