AA 29504 | Alomone Labs A-370 product information

product summary

company name :

Alomone Labs

product type :

chemical

product name :

AA 29504

catalog :

A-370

more info or order :

Alomone Labs product webpage

image

image 1 :

Western blot analysis of human recombinant Nucleobindin-2/Nesfatin-1 (200 ng): - 1.Anti-Nucleobindin-2/Nesfatin-1Antibody (#ACS-011) (1:200).2. Anti-Nucleobindin-2/Nesfatin-1 Antibody preincubated with the negative control antigen.

product information

CAT :

A-370

SKU :

A-370_10 mg

Product Name :

AA 29504

Group Type :

Non Antibodies

Product Type :

S. Molecules

Shipping and storage :

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

Product Page - Scientific background :

AA 29504, a close analogue of retigabine (KCNQ channel opener), acts as a positive allosteric modulator of GABA(A) receptors. A study in adult rats shows that systemic administration of AA 29504 produces anxiolytic effects and reduces motor coordination1.AA 29504 decreases the EC50 value of GABA at the GABA (A) receptors in Xenopus oocytes at over 1 µM. The compound also exhibits agonistic activity on KCNQ channels and demonstrates EC50 values of 9.6-13.5 µM1.GABA(A) receptors are members of the Cys-loop superfamily of ligand-gated ion channels. These receptors mediate GABA action, a major inhibitory neurotransmitter, throughout the central nervous system (CNS). They play an important role in inhibiting cell excitation in the CNS. The GABA(A) receptor is considered to be a major target of antiseizure drugs2,3.

Supplier :

Alomone Labs

Target :

GABA(A) receptors

Long Description :

AA 29504 (#A-370) is a highly pure, synthetic, and biologically active compound.

Short Description :

A Positive Modulator of GABA(A) Receptors

MW :

327.43

Source :

Synthetic

Molecular formula :

C19H25N3O2.

Effective Concentration :

1-100 µM.

Activity :

AA 29504 is a positive allosteric modulator of GABA(A) receptors, reducing the EC50 of GABA and gaboxadol at the α4β3δ and α1β3γ2S receptors in Xenopus oocytes at over 1 µM. AA 29504, a retigabine analogue, also exhibits some agonistic activity on KCNQ channels (EC50=9.6-13.5 µM)1.

Reconstitution and Solubility :

Soluble in DMSO. Centrifuge all product preparations before use (10000 x g, 5 min).

Solubility :

Soluble in DMSO. Centrifuge all product preparations before use (10000 x g, 5 min).

Storage of solutions :

Up to three months at -20°C.

Lead Time :

1-2 Business Days

Country of origin :

Israel/IL

Applications key :

Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.

Purity :

>98%

CAS No :

945828-50-2

Form :

Lyophilized powder.

Comment :

Contact Alomone Labs for technical support and product customization

UNSPSC :

41116134

Bioassay Tested :

Yes

Chemical Name :

Ethyl N-[2-amino-4-[(2,4,6-trimethylphenyl)methylamino]phenyl]carbamate.

more info or order :

Alomone Labs product webpage