A-192621 | Alomone Labs A-360 product information

product summary

company name :

Alomone Labs

product type :

chemical

product name :

A-192621

catalog :

A-360

more info or order :

Alomone Labs product webpage

image

image 1 :

Western blot analysis of rat brain (lanes 1 and 5) mouse brain (lanes 2 and 6) rat pancreas (lanes 3 and 7) and rat pituitary (lanes 4 and 8): - 124.Anti-Nucleobindin-2/Nesfatin-1Antibody (#ACS-011) (1:200).3. Anti-Nucleobindin-2/Nesfatin-1 Antibody (1:400).5-8. Anti-Nucleobindin-2/Nesfatin-1 Antibody preincubated with the negative control antigen.

product information

CAT :

A-360

SKU :

A-360_1 mg

Product Name :

A-192621

Group Type :

Non Antibodies

Product Type :

S. Molecules

Storage After Reconstitution :

The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.

Shipping and storage :

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

Product Page - Scientific background :

A-192621 is a synthetic compound that acts as a selective antagonist of the endothelin B (ET-B) receptor, a member of the G-protein coupled receptor (GPCR) superfamily.In vivo efficacy studies showed that A-192621 inhibits ET-1-induced dilatory and pressor responses that are mediated by ET-B. The compound can cause an increase in arterial blood pressure and plasma ET-1 levels1,2. It inhibits ET-B receptors with an IC50 value of 4.5 nM3.ET-B receptors play an important role in regulating renal function and blood pressure and are expressed in sensory nerves. They are mainly present in medium- and large-sized cell bodies of human trigeminal ganglia4,5.

Supplier :

Alomone Labs

Target :

ET-B receptor

Long Description :

A-192621 (#A-360) is a highly pure, synthetic, and biologically active compound.

Short Description :

A Selective Antagonist of Endothelin B Receptors

MW :

558.68

Source :

Synthetic

Molecular formula :

C33H38N2O6.

Effective Concentration :

0.1-10 nM.

Activity :

A-192621 is a selective antagonist of ET-B endothelin receptors, inhibiting ET-1 binding to ETA and ET-3 binding to ETB receptors with IC50 values of 4280 nM and 4.5 nM, respectively1.In vivo, A-192621 inhibits ETB-mediated dilatory and pressor responses induced by Sarafotoxin 6c (ED50 = 30 mg/kg), and causes an elevation of arterial blood pressure and plasma ET-1 level2.

Reconstitution and Solubility :

Soluble in DMSO or NaOH 1Eq. Centrifuge all products before use (10000 x g 5 min).

Solubility :

Soluble in DMSO or NaOH 1Eq. Centrifuge all products before use (10000 x g 5 min).

Storage of solutions :

Up to three months at -20°C.

Lead Time :

1-2 Business Days

Country of origin :

Israel/IL

Applications key :

Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.

Purity :

>97% (HPLC)

CAS No :

195529-54-5

Form :

Lyophilized Powder

Comment :

Contact Alomone Labs for technical support and product customization

UNSPSC :

41116134

Bioassay Tested :

Yes

Chemical Name :

(2R,3R,4S)-4-(1,3-benzodioxol-5-yl)-1-[2-(2,6-diethylanilino)-2-oxoethyl]-2-(4-propoxyphenyl)pyrrolidine-3-carboxylic acid.

more info or order :

Alomone Labs product webpage