chemical

A 784168

A-345

A-345_10 mg

A 784168

Non Antibodies

S. Molecules

The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

A 784168 is a synthetic and potent antagonist of the TRPV1 channel. A 784168 inhibits human TRPV1 activation by 50 nM capsaicin with an IC50 of 25 nM. A 784168 was found to produce inhibition in 1321N1 astrocytoma cells expressing recombinant human TRPV1 and also in HEK 293 cells. In addition to its inhibition of TRPV1, A 784168 was found to be a very weak antagonist of TRPM8 (IC50 = 20.8 µM) with no effect on TRPA1 channels and a variety of receptors including adenosine, angiotensin, α- and β-adrenergic receptors. A 784168 has a plasma binding capacity of 93.5±0.9% and oral bioavailability of 33%. A 784168 volume of distribution is 12.4L/kg and it has high blood-brain barrier penetrance. Administration of oral A 784168 reduces acute nociceptive behavior induced by capsaicin injection and chronic thermal hyperalgesia induced by CFA injection in a rat model1.

Alomone Labs

TRPV1 channel

A 784168 (#A-345) is a highly pure, synthetic, and biologically active compound.

A Potent Blocker of TRPV1 Channel

479.4

CHEMBL482834

Synthetic

C19H15F6N3O3S.

10 nM - 1 µM.

A 784168 is a potent TRPV1 antagonist, inhibiting human TRPV1 activation by 50 nM capsaicin with IC50 of 25 nM1.

100 mM in DMSO or 50 mM in ethanol. Centrifuge all product preparations before use (10000 x g 5 min).

100 mM in DMSO or 50 mM in ethanol. Centrifuge all product preparations before use (10000 x g 5 min).

Up to four weeks at 4°C or three months at -20°C.

1-2 Business Days

Israel/IL

Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.

>99%

824982-41-4

Lyophilized powder.

Contact Alomone Labs for technical support and product customization

41116134

Yes

1-[3-(trifluoromethyl)pyridin-2-yl]-N-[4-(trifluoromethylsulfonyl)phenyl]-3,6-dihydro-2H-pyridine-4-carboxamide.