(S)-ATPO | Alomone Labs A-330 product information

product summary

company name :

Alomone Labs

product type :

chemical

product name :

(S)-ATPO

catalog :

A-330

more info or order :

Alomone Labs product webpage

image

image 1 :

Alomone Labs ACT-132577inhibits ET-B receptor-mediated Ca2+ mobilization in CHO cells. - Dose-response plot ofACT-132577(#A-350) inhibition of the ET-B receptor-mediated endothelin-1-evoked Ca2+mobilization (IC50= 5.99 M). Cells were loaded with Calcium 6 dye incubated withACT-132577 and stimulated with 30 nM endothelin-1 (EC80). Changes in intracellular Ca2+levels were detected as changes in maximum relative fluorescence (RLU) using FLIPRTETRA?.

product information

CAT :

A-330

SKU :

A-330_10 mg

Product Name :

(S)-ATPO

Group Type :

Non Antibodies

Product Type :

S. Molecules

Storage After Reconstitution :

The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.

Shipping and storage :

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

Product Page - Scientific background :

ATPO, a phosphono amino acid, is a structural hybrid between the NMDA antagonist (RS)-2-amino-7-phosphonoheptanoic acid (AP7) and the AMPA and GluR5 agonist, (RS)-2-amino-3-(5-tert-butyl-3-hydroxy-4-isoxazolyl) propionic acid (ATPA).(S)-ATPO acts as a potent and selective AMPA and kainate receptor antagonist. ATPO has the ability to competitively reduce peak responses evoked by semi-rapid applications of AMPA1. It antagonizes AMPA-induced depolarization in the cortical wedge preparation with an IC50 value of 15 µM1.AMPA receptors are the principal glutamate receptors that mediate fast excitatory neurotransmission. This function is essential for synaptic plasticity and cellular correlate of learning and memory. Antagonists of AMPA receptors are good drug candidates for potential treatment of several neurological disorders such as epilepsy, stroke and amyotrophic lateral sclerosis (ALS)2,3.

Supplier :

Alomone Labs

Target :

AMPA/Kainate receptors

Long Description :

(S)-ATPO (#A-330) is a highly pure, synthetic, and biologically active compound.

Short Description :

An Antagonist of AMPA/Kainate Receptors

MW :

322.25

Synonyms :

CHEMBL5664840

Source :

Synthetic

Molecular formula :

C11H19N2O7P.

Effective Concentration :

0.1-500 µM.

Activity :

An active enantiomer of ATPO, an antagonist of GluR1-4 and a partial agonist of GluR5. (S)-ATPO antagonized AMPA-induced depolarization in the cortical wedge preparation with (IC50 =15 μM)1.

Reconstitution and Solubility :

Up to 100 mM in 1eq NaOH. Centrifuge all products before reconstitution (10000 x g 5 min).

Solubility :

Up to 100 mM in 1eq NaOH. Centrifuge all products before reconstitution (10000 x g 5 min).

Storage of solutions :

Up to four weeks at 4°C or three months at -20°C. It is recommended to aliquot reconstituted stock solutions.

Lead Time :

1-2 Business Days

Country of origin :

Israel/IL

Applications key :

Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.

Purity :

>95%

CAS No :

252930-37-3

Form :

Lyophilized powder.

Comment :

Contact Alomone Labs for technical support and product customization

UNSPSC :

41116134

Bioassay Tested :

Yes

Chemical Name :

(2S)-2-amino-3-[5-tert-butyl-3-(phosphonomethoxy)-1,2-oxazol-4-yl]propanoic acid.

more info or order :

Alomone Labs product webpage