AMTB hydrochloride | Alomone Labs A-305 product information

product summary

company name :

Alomone Labs

product type :

chemical

product name :

AMTB hydrochloride

catalog :

A-305

more info or order :

Alomone Labs product webpage

citations: 2

Reference
Huang Y, Li S, Jia Z, Zhao W, Zhou C, Zhang R, et al. Transient Receptor Potential Melastatin 8 (TRPM8) Channel Regulates Proliferation and Migration of Breast Cancer Cells by Activating the AMPK-ULK1 Pathway to Enhance Basal Autophagy. Front Oncol. 2020;10:573127 pubmed publisher
Sanders K, Hashimoto T, Sakai K, Akiyama T. Modulation of Itch by Localized Skin Warming and Cooling. Acta Derm Venereol. 2018;98:855-861 pubmed publisher

product information

CAT :

A-305

SKU :

A-305_10 mg

Product Name :

AMTB hydrochloride

Group Type :

Non Antibodies

Product Type :

S. Molecules

Storage After Reconstitution :

Store the reconstituted solution for the shortest time possible at -20°C. We do not recommend storing the product in working solution for longer than one day. Avoid multiple freeze-thaw cycles.

Shipping and storage :

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

Product Page - Scientific background :

AMTB hydrochloride is a TRPM8 channel blocker, able to inhibit icilin-induced human TRPM8 channel activation. The compound shows very little affinity for TRPV1 and TRPV4 channels and is being used as a tool to evaluate the role of TRPM8 channels in different animal models1. TRPM8 channel blockers may provide a new therapeutic treatment for overactive and painful bladder syndrome1,2.TRPM8 channel is a member of the TRP channel superfamily. TRPM8 is a Ca2+-permeable, nonselective cation channel that is activated by temperatures in the range of 8-28°C and by chemical agonists such as menthol and icilin. The channel is specifically expressed in temperature-sensing trigeminal and dorsal root ganglion neurons. It's expression is up-regulated in prostate cancer and other malignancies3,4.

Supplier :

Alomone Labs

Target :

TRPM8 channel

Long Description :

AMTB hydrochloride (#A-305) is a highly pure, synthetic, and biologically active compound.

Short Description :

A Blocker of TRPM8 Channels

MW :

430.99

Source :

Synthetic

Molecular formula :

C23H27ClN2O2S.

Effective Concentration :

1-100 µM.

Activity :

AMTB hydrochloride is a TRPM8 channel blocker, inhibiting icilin-induced human TRPM8 channel activation (pIC50 = 6.23), selective over TRPV1 and TRPV41.

Reconstitution and Solubility :

Up to 100 mM in DMSO. Centrifuge all products before use (10000 x g 5 min).

Solubility :

Up to 100 mM in DMSO. Centrifuge all products before use (10000 x g 5 min).

Storage of solutions :

Up to three months at -20°C.

Lead Time :

1-2 Business Days

Country of origin :

Israel/IL

Applications key :

Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.

Purity :

>97%

CAS No :

926023-82-7

Form :

Lyophilized powder.

Comment :

Contact Alomone Labs for technical support and product customization

UNSPSC :

41116134

Bioassay Tested :

Yes

Chemical Name :

N-(3-aminopropyl)-2-[(3-methylphenyl)methoxy]-N-(thiophen-2-ylmethyl)benzamide;hydrochloride.

more info or order :

Alomone Labs product webpage