AMG-9090 | Alomone Labs A-300 product information

product summary

company name :

Alomone Labs

product type :

chemical

product name :

AMG-9090

catalog :

A-300

more info or order :

Alomone Labs product webpage

image

image 1 :

Alomone Labs IRL 2500 inhibits ETB receptor-mediated Ca2+mobilization in CHO cells. - Dose response plot ofIRL 2500(#I-190) inhibition of the ETB receptor-mediated endothelin-1-evoked Ca2+mobilization (IC50= 179.6 nM). Cells were loaded with Calcium 6 dye incubated with IRL 2500 and stimulated with 30 nM endothelin-1 (EC80). Changes in intracellular Ca2+levels were detected as changes in maximum relative fluorescence (RLU) using FLIPRTETRA?.

product information

CAT :

A-300

SKU :

A-300_10 mg

Product Name :

AMG-9090

Group Type :

Non Antibodies

Product Type :

S. Molecules

Storage After Reconstitution :

The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.

Shipping and storage :

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

Product Page - Scientific background :

AMG-9090 is a small synthetic molecule that acts as a TRPA1 channel blocker. AMG-9090 was shown to inhibit intracellular calcium increase mediated by human TRPA1 channels in Chinese hamster ovary cells with IC50 values of 21 nM1. The compound also possesses inhibitory effects on human TRPM8 and TRPV1 channels1,2.TRPA1 channels are non-selective cation channels expressed in the small neurons of the dorsal root and trigeminal ganglia. They play an important role in models of inflammatory and neuropathic pain and have the ability to detect pungent or irritant compounds.Studies have shown that blockade of TRPA1 channels may help in migraine attack and can be used as a possible new target for its treatment. Also, evidence shows that TRPA1 blockers could serve as novel therapeutic strategies for chemotherapeutic induced peripheral neuropathy1,3.

Supplier :

Alomone Labs

Target :

TRPA1, TRPM8, TRPV1 channels

Long Description :

AMG-9090 (#A-300) is a highly pure, synthetic, and biologically active compound.

Short Description :

A Blocker of TRPA1, TRPV1 and TRPM8 Channels

MW :

395.12

Source :

Synthetic

Molecular formula :

C15H11Cl4NOS.

Effective Concentration :

50 nM - 50 µM.

Activity :

AMG-9090 is TRPA1 channel blocker, shown to potently and concentration-dependently inhibit AITC-induced increase in intracellular calcium mediated by human TRPA1 (IC50 = 21 nM)1,2. The compound also possesses inhibitory effects on human TRPM8 and TRPV1 channels1,2.

Reconstitution and Solubility :

Up to 50 mM in DMSO. Centrifuge all products before use (10000 x g 5 min).

Solubility :

Up to 50 mM in DMSO. Centrifuge all products before use (10000 x g 5 min).

Storage of solutions :

Up to three months at -20°C.

Lead Time :

1-2 Business Days

Country of origin :

Israel/IL

Applications key :

Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.

Purity :

>98%

CAS No :

118215-82-0

Form :

Lyophilized powder.

Comment :

Contact Alomone Labs for technical support and product customization

UNSPSC :

41116134

Bioassay Tested :

Yes

Chemical Name :

N-[2,2,2-trichloro-1-(4-chlorophenyl)sulfanylethyl]benzamide.

more info or order :

Alomone Labs product webpage