Arcaine sulfate | Alomone Labs A-285 product information

product summary

company name :

Alomone Labs

product type :

chemical

product name :

Arcaine sulfate

catalog :

A-285

more info or order :

Alomone Labs product webpage

citations: 1

Reference
Kellner S, Abbasi A, Carmi I, Heinrich R, Garin Shkolnik T, Hershkovitz T, et al. Two de novo GluN2B mutations affect multiple NMDAR-functions and instigate severe pediatric encephalopathy. elife. 2021;10: pubmed publisher

product information

CAT :

A-285

SKU :

A-285_100 mg

Product Name :

Arcaine sulfate

Group Type :

Non Antibodies

Product Type :

S. Molecules

Storage After Reconstitution :

The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.

Shipping and storage :

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

Product Page - Scientific background :

Glutamate is the main excitatory neurotransmitter in the CNS and is also involved in a variety of pathological conditions including epilepsy. Glutamate binds to the ionotropic NMDA receptor to relay its excitatory signal.Arcaine sulfate is a competitive inhibitor of the NMDA receptor and also an inhibitor of the enzyme NO synthase. It has an effective concentration of 50-500 µM and an IC50 of 61 μM at -60 mV. Arcaine binds to the polyamine recognition site of the NMDA receptor complex and blocks the receptor in a concentration- and voltage-dependent manner. At positive membrane potentials Arcaine does not produce a blocking effect. In the presence of 100 μM Arcaine (at -60 mV), NMDA amplitude whole cell currents are reduced by 67% and by 69% in single channel recordings. The inhibitory effect of Arcaine is rapid in onset and recovery (

Supplier :

Alomone Labs

Target :

NMDA receptors

Long Description :

Arcaine sulfate (#A-285) is a highly pure, synthetic, and biologically active compound.

Short Description :

An Antagonist of NMDA Receptors

MW :

270.31

Source :

Synthetic

Molecular formula :

C6H18N6O4S.

Effective Concentration :

50-500 µM.

Activity :

Arcane is an NMDA receptor antagonist with KD of 61 µM at -60 mV1.

Reconstitution and Solubility :

20 mM in water. Centrifuge all product preparations before use (10,000 x g for 1 min).

Solubility :

20 mM in water. Centrifuge all product preparations before use (10,000 x g for 1 min).

Storage of solutions :

Up to four weeks at 4°C or three months at -20°C.

Lead Time :

1-2 Business Days

Country of origin :

Israel/IL

Applications key :

Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.

Purity :

>95%

CAS No :

14923-17-2

Form :

Lyophilized powder.

Comment :

Contact Alomone Labs for technical support and product customization

UNSPSC :

41116134

Bioassay Tested :

Yes

Chemical Name :

2-[4-(diaminomethylideneamino)butyl]guanidine;sulfuric acid.

more info or order :

Alomone Labs product webpage