cis-ACBD | Alomone Labs A-281 product information

product summary

company name :

Alomone Labs

product type :

chemical

product name :

cis-ACBD

catalog :

A-281

more info or order :

Alomone Labs product webpage

image

image 1 :

Alomone Labs TAK-044 inhibits Endothelin-B receptor-mediated Ca2+ mobilization in CHO cells. - Cells were loaded with Calcium-6 dye incubated with different concentrations ofTAK-044(#SPE-320) and stimulated by 30 nM Endothelin-1 (EC80). Changes in intracellular Ca2+were monitored as changes in relative fluorescence (RLU) using FLIPRTETRA. IC50was determined as 0.66 M.

product information

CAT :

A-281

SKU :

A-281_10 mg

Product Name :

cis-ACBD

Group Type :

Non Antibodies

Product Type :

S. Molecules

Storage After Reconstitution :

Store the reconstituted solution for the shortest time possible at -20°C. We do not recommend storing the product in working solution for longer than one day. Avoid multiple freeze-thaw cycles.

Shipping and storage :

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

Product Page - Scientific background :

trans-ACBD is a potent, competitive and selective activator of glutamate uptake. The compound acts as an NMDA (N-methyl-D-aspartate) receptor agonist. The ACBD structure includes two isomers: cis-1-aminocyclobutane-1,3-dicarboxylic acid and trans-1-aminocyclobutane-1,3-dicarboxylic acid. Several studies have shown that the trans isomer is more potent than the cis isomer. The trans isomer was also shown to be 20 times more active than NMDA1,2, the major excitatory neurotransmitter in the mammalian central nervous system (CNS).Several studies suggest that modifications and changes of glutamate uptake could play a role in processes underlying synaptic plasticity in the CNS2.NMDA receptors are ion channels gated by glutamate. Glutamate-mediated signaling is important for basic neuron-neuron signaling and neuronal processes such as learning, memory and pain perception3.

Supplier :

Alomone Labs

Target :

NMDA receptors

Long Description :

cis-ACBD (#A-281) is a highly pure, synthetic, and biologically active compound.

Short Description :

An Agonist of NMDA Receptors

MW :

159.14

Synonyms :

1-Aminocyclobutane-1,3-dicarboxylic acid

Source :

Synthetic

Molecular formula :

C6H9NO4.

Effective Concentration :

10-500 µM.

Activity :

cis-ACBD is a weak NMDA receptor agonist1,2.

Reconstitution and Solubility :

500 mM in H2O. Centrifuge all product preparations before use (10,000 x g for 1 min).

Solubility :

500 mM in H2O. Centrifuge all product preparations before use (10,000 x g for 1 min).

Storage of solutions :

Up to four weeks at 4°C or three months at -20°C.

Lead Time :

1-2 Business Days

Country of origin :

Israel/IL

Applications key :

Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.

Purity :

>95%

CAS No :

73550-55-7

Form :

Lyophilized powder.

Comment :

Contact Alomone Labs for technical support and product customization

UNSPSC :

41116134

Bioassay Tested :

Yes

Chemical Name :

1-aminocyclobutane-1,3-dicarboxylic acid.

more info or order :

Alomone Labs product webpage