chemical

trans-ACBD

A-280

A-280_10 mg

trans-ACBD

Non Antibodies

S. Molecules

The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

trans-ACBD is a potent, competitive and selective activator of glutamate uptake. The compound acts as an NMDA (N-methyl-D-aspartate) receptor agonist. The ACBD structure includes two isomers: cis-1-aminocyclobutane-1,3-dicarboxylic acid and trans-1-aminocyclobutane-1,3-dicarboxylic acid. Several studies have shown that the trans isomer is more potent than the cis isomer. The trans isomer was also shown to be 20 times more active than NMDA1,2, the major excitatory neurotransmitter in the mammalian central nervous system (CNS).Several studies suggest that modifications and changes of glutamate uptake could play a role in processes underlying synaptic plasticity in the CNS2.NMDA receptors are ion channels gated by glutamate. Glutamate-mediated signaling is important for basic neuron-neuron signaling and neuronal processes such as learning, memory and pain perception3.

Alomone Labs

NMDA receptors

trans-ACBD (#A-280) is a highly pure, synthetic, and biologically active compound.

An Agonist of NMDA Receptors

159.14

1-Aminocyclobutane-1,3-dicarboxylic acid

Synthetic

C6H9NO4.

0.1-20 µM.

trans-ACBD is an NMDA receptor agonist1,2.

500 mM in H2O. Centrifuge all product preparations before use (10,000 x g for 1 min).

500 mM in H2O. Centrifuge all product preparations before use (10,000 x g for 1 min).

Up to four weeks at 4°C or three months at -20°C.

1-2 Business Days

Israel/IL

Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.

>95%

117488-23-0

Lyophilized powder.

Contact Alomone Labs for technical support and product customization

41116134

Yes

1-aminocyclobutane-1,3-dicarboxylic acid.