(RS)-AMPA | Alomone Labs A-265 product information

product summary

company name :

Alomone Labs

product type :

chemical

product name :

(RS)-AMPA

catalog :

A-265

more info or order :

Alomone Labs product webpage

citations: 11

Reference
Iuliano M, Seeley C, Sapp E, Jones E, Martin C, Li X, et al. Disposition of Proteins and Lipids in Synaptic Membrane Compartments Is Altered in Q175/Q7 Huntington's Disease Mouse Striatum. Front Synaptic Neurosci. 2021;13:618391 pubmed publisher
Kuhlmann N, Wagner Valladolid M, Quesada Ramírez L, Farrer M, Milnerwood A. Chronic and Acute Manipulation of Cortical Glutamate Transmission Induces Structural and Synaptic Changes in Co-cultured Striatal Neurons. Front Cell Neurosci. 2021;15:569031 pubmed publisher
Nishitani A, Nagayoshi H, Takenaka S, Asano M, Shimizu S, Ohno Y, et al. Involvement of NMDA receptors in tremor expression in Aspa/Hcn1 double-knockout rats. Exp Anim. 2020;69:388-394 pubmed publisher
Yeung J, Palpagama T, Tate W, Peppercorn K, Waldvogel H, Faull R, et al. The Acute Effects of Amyloid-Beta1-42 on Glutamatergic Receptor and Transporter Expression in the Mouse Hippocampus. Front Neurosci. 2019;13:1427 pubmed publisher
Avazzadeh S, McDonagh K, Reilly J, Wang Y, Boomkamp S, McInerney V, et al. Increased Ca2+ signaling in NRXN1α +/- neurons derived from ASD induced pluripotent stem cells. Mol Autism. 2019;10:52 pubmed publisher
Shi G, Xing L, Wu D, Bhattacharyya B, Jones C, McMahon T, et al. A Rare Mutation of β1-Adrenergic Receptor Affects Sleep/Wake Behaviors. Neuron. 2019;103:1044-1055.e7 pubmed publisher
Lambert M, Ipsen T, Kohlmeier K. Acute cocaine exposure elicits rises in calcium in arousal-related laterodorsal tegmental neurons. Pharmacol Res Perspect. 2017;5:e00282 pubmed publisher
Pollak J, Rai K, Funk C, Arora S, Lee E, Zhu J, et al. Ion channel expression patterns in glioblastoma stem cells with functional and therapeutic implications for malignancy. PLoS ONE. 2017;12:e0172884 pubmed publisher
Zhu J, Lee K, Jewett K, Man H, Chung H, Tsai N. Epilepsy-associated gene Nedd4-2 mediates neuronal activity and seizure susceptibility through AMPA receptors. PLoS Genet. 2017;13:e1006634 pubmed publisher
Leshchyns ka I, Liew H, Shepherd C, Halliday G, Stevens C, Ke Y, et al. AÎ²-dependent reduction of NCAM2-mediated synaptic adhesion contributes to synapse loss in Alzheimer's disease. Nat Commun. 2015;6:8836 pubmed publisher
Khosravani H, Zhang Y, Tsutsui S, Hameed S, Altier C, Hamid J, et al. Prion protein attenuates excitotoxicity by inhibiting NMDA receptors. J Cell Biol. 2008;181:551-65 pubmed publisher

product information

CAT :

A-265

SKU :

A-265_10 mg

Product Name :

(RS)-AMPA

Group Type :

Non Antibodies

Product Type :

S. Molecules

Storage After Reconstitution :

The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.

Shipping and storage :

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

Product Page - Scientific background :

Glutamate is the main excitatory neurotransmitter in the CNS. It is also involved in a variety of pathological conditions including epilepsy. Glutamate binds to a number of different receptor types such as the AMPA, kainate and NMDA receptors that relay its excitatory activity.(RS)-AMPA is a synthetic AMPA receptor agonist. It has an effective concentration of 0.1-100 µM. RS-AMPA selectively binds to AMPA receptors over the other types of glutamate receptors. RS-AMPA was found to elicit feeding behavior in a rat model while RS-AMPA's enantiomer did not produce similar results1.

Supplier :

Alomone Labs

Target :

AMPA receptors

Long Description :

(RS)-AMPA (#A-265) is a highly pure, synthetic, and biologically active compound.

Short Description :

An Agonist of AMPA Receptors

MW :

186.16

Synonyms :

AMPA

Source :

Synthetic

Molecular formula :

C7H10N2O4.

Effective Concentration :

0.1-100 µM.

Activity :

(RS)-AMPA is a selective AMPA receptor agonist1.

Reconstitution and Solubility :

10 mM in H2O. Centrifuge all product preparations before use (10,000 x g for 1 min).

Solubility :

10 mM in H2O. Centrifuge all product preparations before use (10,000 x g for 1 min).

Storage of solutions :

Up to four weeks at 4°C or three months at -20°C.

Lead Time :

1-2 Business Days

Country of origin :

Israel/IL

Applications key :

Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.

Purity :

>99% (HPLC)

CAS No :

74341-63-2

Form :

Lyophilized powder.

Comment :

Contact Alomone Labs for technical support and product customization

UNSPSC :

41116134

Bioassay Tested :

Yes

Cited Application :

Electrophysiology

Chemical Name :

2-amino-3-(5-methyl-3-oxo-1,2-oxazol-4-yl)propanoic acid.

more info or order :

Alomone Labs product webpage