chemical

α-Asarone

A-260

A-260_1 g

α-Asarone

Non Antibodies

S. Molecules

The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

α-Asarone is an active component of the Chinese medicinal plant Acorus tatarinouii Schott and exhibits a variety of pharmacological activities such as anti-hyperlipidemic, anti-coagulant, anti-tumor, anti-viral, and anti-inflammatory1,2.α-Asarone acts as a NaV channel blocker, GABA(A) receptor blocker and TrkB receptor inhibitor and is available in the market in the form of tablets, capsules and injections1.The neuroprotective actions of α-asarone are exhibited through the blockade of N-methyl-D-aspartate (NMDA) receptor and by inhibition of nitric oxide (NO) overproduction in brain tissue. α-Asarone also exhibits anti-oxidative properties, reduces levels of superoxide dismutase (SOD), catalase, and glutathione peroxidase in the hippocampus against noise-stress and in various seizure models3.Recent studies have shown that α-asarone has the ability to improve multiple physiological actions, to produce a variety of pharmacological actions in the CNS and modulate immune system functions. The anti-convulsant activity of α-asarone has been reported in several recent studies in epileptic seizure animal models3.α-Asarone was shown to be effective in attenuating foam cell formation and enhancing cholesterol efflux4. In addition, it protects against angiotensin II-mediated damage of endothelial cells and can be developed for the prevention of injury to cardiovascular tissues2.α-Asarone may serve as a preventive and regenerative therapeutic agent to promote neurogenesis against age-related neurodegeneration and neurodegenerative disorders5.

Alomone Labs

NaV channels, GABA(A) receptors, TrkB receptors, NMDA receptors

α-Asarone (#A-260) is a highly pure, natural, and biologically active compound.

An Antagonist of NaV Channels, GABA(A) Receptors, NMDA Receptors and an Inhibitor of TrkB Receptor

208.3

Asarone, trans-Isoasarone, Etherophenol

Natural

C12H16O3.

1-500 µM.

α-Asarone 100 μM to 1 mM inhibits NaV1.2 channel currents. It also blocks GABA(A) receptors in neurons1. α-Asarone blocks corticosterone-induced anxiety-like behaviours via modulating TrkB signaling process2.

100 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).

100 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).

Up to four weeks at 4°C or three months at -20°C.

1-2 Business Days

Israel/IL

Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.

>99%

2883-98-9

Lyophilized powder.

Contact Alomone Labs for technical support and product customization

41116134

Yes

1,2,4-trimethoxy-5-[(E)-prop-1-enyl]benzene.