chemical

Azasetron

A-240

A-240_10 mg

Azasetron

Non Antibodies

S. Molecules

The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

Azasetron is a potent and selective 5-HT3 receptor antagonist. It antagonizes the channel by binding to 5-HT3 receptors thereby blocking the serotonin binding site and antagonizing the indirect sympathomimetic responses to 5-HT3.The compound is classified as a derivative of benzamide with a longer duration of action and higher affinity than other 5-HT3 receptor antagonists.Azasetron is highly effective in preventing postoperative and chemotherapy-induced nausea and vomiting induced by anticancer drugs and radiotherapy1,2. Therefore, in most cases 5-HT3 receptor antagonists are co-administered with anticancer drugs3.The 5-HT3 receptor subtype is a member of the cys-loop ligand-gated cation channels expressed throughout the central and peripheral nervous systems and mediate a variety of important physiological functions4.

Alomone Labs

5-HT3A, 5-HT3B

Azasetron (#A-240) is a highly pure, synthetic, and biologically active compound.

A Potent and Selective Antagonist of 5-HT3 Channels

349.8

Y-25130

Synthetic

C17H20ClN3O3.

0.1-100 nM.

Azasetron is a potent and selective 5-HT3 channel blocker with Ki ~2.9 nM1.

100-150 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).

100-150 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).

Up to four weeks at 4°C or three months at -20°C.

1-2 Business Days

Israel/IL

Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.

>98%

123040-93-7

Lyophilized powder.

Contact Alomone Labs for technical support and product customization

41116134

Yes

N-(1-azabicyclo[2.2.2]octan-3-yl)-6-chloro-4-methyl-3-oxo-1,4-benzoxazine-8-carboxamide.