chemical

A 967079

A-225

A-225_10 mg

A 967079

Non Antibodies

S. Molecules

The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

The transient receptor potential (TRP) channel is one of the largest families of cation channels1.TRPA1 is expressed in sensory and nociceptive neurons and has a significant role in the inflammatory response. Bradykinin and histamine receptors induce TRPA1 activity. It has been found that TRPA1 deficient mice do not develop an elevated mechanical and thermal pain response following bradykinin injection. This suggests that TRPA1 has a vital role in bradykinin signaling pathways2.TRPA1 also plays a role in acute and chronic respiratory disease pathophysiology. Prolonged exposure to TRPA1 agonists such as chlorine and aldehydes can cause reactive airway dysfunction syndrome characterized by symptoms such as wheezing, cough and dyspnea. In view of this, TRPA1 is a potential target in airway anti-inflammatory research3.A 967079 is a TRPA1 blocker and has an IC50 value of 67 and 289 nM for human and rat TRPA1 receptors respectively.

Alomone Labs

TRPA1 channels

A 967079 (#A-225) is a highly pure, synthetic, and biologically active compound.

A Blocker of TRPA1 Channels

207.2

Synthetic

C12H14FNO.

10 nM - 100 µM.

A 967079 is a blocker of TRPA1 channels and has IC50 values of 67 and 289 nM at human and rat TRPA1 receptors respectively1.

Up to 200 mM in DMSO. Centrifuge all product preparations before use (5,000 x g for 1 min).

Up to 200 mM in DMSO. Centrifuge all product preparations before use (5,000 x g for 1 min).

Up to four weeks at 4°C or three months at -20°C.

1-2 Business Days

Israel/IL

Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.

>99% (HPLC)

1170613-55-4

Lyophilized powder.

Contact Alomone Labs for technical support and product customization

41116134

Yes

(NZ)-N-[(E)-1-(4-fluorophenyl)-2-methylpent-1-en-3-ylidene]hydroxylamine.