3-AQC | Alomone Labs A-205 product information

product summary

company name :

Alomone Labs

product type :

chemical

product name :

3-AQC

catalog :

A-205

more info or order :

Alomone Labs product webpage

image

image 1 :

Alomone Labs 3-AQC blocks 5-HT3A channels expressed in HEK 293T cells. - Currents were elicited by 10 M 5-HT delivered every 3 minutes. 3-AQC (#A-205) was applied 30 seconds before stimulation at 10 and 100 M as indicated and inhibited the 5-HT induced current in a dose-dependent and reversible manner.

product information

CAT :

A-205

SKU :

A-205_10 mg

Product Name :

3-AQC

Group Type :

Non Antibodies

Product Type :

S. Molecules

Storage After Reconstitution :

The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.

Shipping and storage :

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

Product Page - Scientific background :

Serotonin (5-hydroxytryptamine, 5-HT) is a monoamine neurotransmitter synthesized from the amino acid tryptophan by the enzyme tryptophan-decarboxylase. The 5-HT3 channel is a ligand gated ion channel receptor of the cys-loop channel family. It is a pentamer with five subunits surrounding a central channel1.3-AQC is a potent and selective antagonist of the 5-HT3A channel. 3-AQC is a derivative of Piperazinyquinoxaline synthetically designed to be 100 times more potent in blocking Serotonin receptors than Tropisetron.

Supplier :

Alomone Labs

Target :

5-HT3A channel

Long Description :

3-AQC (#A-205) is a highly pure, synthetic, and biologically active compound.

Short Description :

An Antagonist of 5-HT3 Channels

MW :

395.41

Source :

Synthetic

Molecular formula :

C20H21N5O4.

Effective Concentration :

1-100 µM.

Activity :

3-AQC is a potent and selective 5-HT3A receptor antagonist1.

Reconstitution and Solubility :

100 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).

Solubility :

100 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).

Storage of solutions :

Up to four weeks at 4°C or three months at -20°C.

Lead Time :

1-2 Business Days

Country of origin :

Israel/IL

Applications key :

Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.

Purity :

>98%

CAS No :

149685-89-2

Form :

Lyophilized powder.

Comment :

Contact Alomone Labs for technical support and product customization

UNSPSC :

41116134

Bioassay Tested :

Yes

Chemical Name :

3-(4-allylpiperazin-1-yl)-2-quinoxalinecarbonitrile maleate.

more info or order :

Alomone Labs product webpage