4-Aminopyridine | Alomone Labs A-115 product information

product summary

company name :

Alomone Labs

product type :

chemical

product name :

4-Aminopyridine

catalog :

A-115

quantity :

25 g

citations: 12

Reference
Manoukian O, Rudraiah S, Arul M, Bartley J, Baker J, Yu X, et al. Biopolymer-nanotube nerve guidance conduit drug delivery for peripheral nerve regeneration: In vivo structural and functional assessment. Bioact Mater. 2021;6:2881-2893 pubmed publisher
Tyagi S, Bendrick T, Filipova D, Papadopoulos S, Bannister R. A mutation in CaV2.1 linked to a severe neurodevelopmental disorder impairs channel gating. J Gen Physiol. 2019;151:850-859 pubmed publisher
Manoukian O, Arul M, Rudraiah S, Kalajzic I, Kumbar S. Aligned microchannel polymer-nanotube composites for peripheral nerve regeneration: Small molecule drug delivery. J Control Release. 2019;296:54-67 pubmed publisher
Abs E, Poorthuis R, Apelblat D, Muhammad K, Pardi M, Enke L, et al. Learning-Related Plasticity in Dendrite-Targeting Layer 1 Interneurons. Neuron. 2018;100:684-699.e6 pubmed publisher
Lim L, Pakan J, Selten M, Marques Smith A, Llorca A, Bae S, et al. Optimization of interneuron function by direct coupling of cell migration and axonal targeting. Nat Neurosci. 2018;21:920-931 pubmed publisher
Madry C, Kyrargyri V, Arancibia Carcamo I, Jolivet R, Kohsaka S, Bryan R, et al. Microglial Ramification, Surveillance, and Interleukin-1? Release Are Regulated by the Two-Pore Domain K+ Channel THIK-1. Neuron. 2018;97:299-312.e6 pubmed publisher
Melonakos E, White J, Fernandez F. Gain Modulation of Cholinergic Neurons in the Medial Septum-Diagonal Band of Broca Through Hyperpolarization. Hippocampus. 2016;26:1525-1541 pubmed publisher
Gimenez Cassina A, Martínez François J, Fisher J, Szlyk B, Polak K, Wiwczar J, et al. BAD-dependent regulation of fuel metabolism and K(ATP) channel activity confers resistance to epileptic seizures. Neuron. 2012;74:719-30 pubmed publisher
Tegla C, Cudrici C, Rozycka M, Soloviova K, Ito T, Singh A, et al. C5b-9-activated, K(v)1.3 channels mediate oligodendrocyte cell cycle activation and dedifferentiation. Exp Mol Pathol. 2011;91:335-45 pubmed publisher
Large R, Hollywood M, Sergeant G, Thornbury K, Bourke S, Levick J, et al. Ionic currents in intimal cultured synoviocytes from the rabbit. Am J Physiol Cell Physiol. 2010;299:C1180-94 pubmed publisher
Norris A, Nerbonne J. Molecular dissection of I(A) in cortical pyramidal neurons reveals three distinct components encoded by Kv4.2, Kv4.3, and Kv1.4 alpha-subunits. J Neurosci. 2010;30:5092-101 pubmed publisher
Greenhill S, Jones R. Diverse antiepileptic drugs increase the ratio of background synaptic inhibition to excitation and decrease neuronal excitability in neurones of the rat entorhinal cortex in vitro. Neuroscience. 2010;167:456-74 pubmed publisher

product information

Product Category :

Small Molecule

Product Name :

4-Aminopyridine

Product Description :

4-Aminopyridine is a non-selective Kv channel blocker, which blocks nearly all Kv currents although its potency varies over a wide range. It blocks Kv 2.1 and Kv 3.1 channels with IC50 of 18 and 0.1 mM, respectively, in oocytes. Kv 1.1 and Kv 1.2 channels are blocked by 4-AP with IC50 of 147 muM and 230 muM, respectively, in CHO cells. It has also been used in the clinic to manage some of the symptoms of Multiple Sclerosis.

Package Content :

Reagent vial, SDS documentation

Brand Name :

Alomone Labs

ManufacturerCatalogID :

A-115

SupplierCatalogID :

A-115

Packaging Quantity :

1

Product Size/Quantity :

25 g

Unit :

g

Minimum Order Quantity :

1

Shipping Country [US] :

Israel

Default Carrier [US] :

Fedex

Order Processing Time [US] :

1

Est. Transit Time [US] :

3

Shipping Country [GB] :

Israel

Default Carrier [GB] :

Fedex

Order Processing Time [GB] :

1

Est. Transit Time [GB] :

3

Shipping Country [EU] :

Israel

Default Carrier [EU] :

Fedex

Order Processing Time [EU] :

1

Est. Transit Time [EU] :

3

US HS Code :

2933.39.9200

EU HS Code :

2933399990

Shipping Details :

Ship at room temperature, temperature stabilized product

Alternative names :

4-AP

CAS# :

504-24-5

Target :

Kv K+ channels

Activity :

4-Aminopyridine is a non-selective Kv channel blocker, which blocks nearly all Kv currents although its potency varies over a wide range. It blocks Kv 2.1 and Kv 3.1 channels with IC50 of 18 and 0.1 mM, respectively, in oocytes. Kv 1.1 and Kv 1.2 channels are blocked by 4-AP with IC50 of 147 muM and 230 muM, respectively, in CHO cells. It has also been used in the clinic to manage some of the symptoms of Multiple Sclerosis.

Type :

Antagonists & Inhibitors

Molecule Name :

4-Aminopyridine.

Gene/Protein ID :

KCNA1, KCNA2, KCNA3, KCNA4, KCNA5, KCNA6, KCNA7, KCNA8, KCNB1, KCNC1, KCNC4, KCNC2

Source :

Synthetic

Formula :

C5H6N2

Molecular Weight :

94.1

Format :

Lyophilized/solid.

Purity :

>99% (HPLC)

Primary Category :

Ion Channels > K+ Channels > Voltage-Gated K+ Channels > Blockers