A-803467 | Alomone Labs A-105 product information

product summary

company name :

Alomone Labs

product type :

chemical

product name :

A-803467

catalog :

A-105

more info or order :

Alomone Labs product webpage

citations: 5

Reference
Zheng Y, Liu P, Bai L, Trimmer J, Bean B, Ginty D. Deep Sequencing of Somatosensory Neurons Reveals Molecular Determinants of Intrinsic Physiological Properties. Neuron. 2019;103:598-616.e7 pubmed publisher
Zhang X, Cao X, Lai R, Xie M, Zeng W. Puerarin Relieves Paclitaxel-Induced Neuropathic Pain: The Role of Nav1.8 β1 Subunit of Sensory Neurons. Front Pharmacol. 2018;9:1510 pubmed publisher
Xie M, Yang J, Pang R, Zeng W, Ouyang H, Liu Y, et al. Bulleyaconitine A attenuates hyperexcitability of dorsal root ganglion neurons induced by spared nerve injury: The role of preferably blocking Nav1.7 and Nav1.3 channels. Mol Pain. 2018;14:1744806918778491 pubmed publisher
Anreddy N, Patel A, Zhang Y, Wang Y, Shukla S, Kathawala R, et al. A-803467, a tetrodotoxin-resistant sodium channel blocker, modulates ABCG2-mediated MDR in vitro and in vivo. Oncotarget. 2015;6:39276-91 pubmed publisher
Lu V, Ikeda S, Puhl H. A 3.7 kb fragment of the mouse Scn10a gene promoter directs neural crest but not placodal lineage EGFP expression in a transgenic animal. J Neurosci. 2015;35:8021-34 pubmed publisher

image

image 1 :

Western blot analysis of mouse brain lysate: - 1. Anti-KCNS2 (KV9.2) Antibody (#APC-132) (1:200).2. Anti-KCNS2 (KV9.2) Antibody preincubated with the negative control antigen.

product information

CAT :

A-105

SKU :

A-105_10 mg

Product Name :

A-803467

Group Type :

Non Antibodies

Product Type :

S. Molecules

Storage After Reconstitution :

The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.

Shipping and storage :

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

Product Page - Scientific background :

The TTX-resistant NaV1.8 channel is expressed almost exclusively in the PNS and has been shown to mediate most of the well documented TTX-resistant currents of DRG neurons' action potentials1. Hyperexcitability, manifested by increased action potential firing and coded information transfer to the CNS of nociceptive DRG neurons, probably lie on the basis of several pathological pain states. Both genetic and pharmacological evidence suggest that NaV1.8 channel might serve as a target in pain control2-4.A-803467 is a potent and selective blocker of the TTX-resistant NaV1.8 channel4. A-803467 is a state dependent inhibitor with IC50 8 nM at depolarized membrane potential (-40 mV) and 80 nM at -100 mV. As an efficient inhibitor of TTX-resistant currents in DRG neurons, A-803467 was also effective as an analgesic in several rodent models of different pathological pain states4,5. A-803467 was used as a pharmacological tool to demonstrate the expression of NaV1.8 in the heart conduction system and its contribution to QRS interval in the mouse heart6.

Supplier :

Alomone Labs

Target :

NaV1.8 Na+ channels

Long Description :

A-803467 (#A-105) is a highly pure, synthetic, and biologically active compound.

Short Description :

A Potent and Selective Blocker of the TTX-Resistant NaV1.8 Channel

MW :

357.8

Source :

Synthetic

Molecular formula :

C19H16ClNO4.

Effective Concentration :

10 nM - 10 μM.

Activity :

A-803467 is a potent and selective blocker of the TTX-resistant NaV1.8 channel. A-803467 is a state dependent inhibitor with IC50 of 8 nM at depolarized membrane potential (-40 mV) and 80 nM at -100 mV. As an efficient inhibitor of TTX-resistant currents in DRG neurons, A-803467 was also effective as an analgesic in several rodent models of different pathological pain states1,2. A-803467 was used as a pharmacological tool to demonstrate the expression of NaV1.8 in the heart conduction system and its contribution to QRS interval in the mouse heart3.

Reconstitution and Solubility :

DMSO. Centrifuge all product preparations before use (10000 x g 5 min).

Solubility :

DMSO. Centrifuge all product preparations before use (10000 x g 5 min).

Storage of solutions :

Up to four weeks at 4°C or three months at -20°C.

Lead Time :

1-2 Business Days

Country of origin :

Israel/IL

Applications key :

Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.

Purity :

>99% (HPLC)

CAS No :

944261-79-4

Form :

Lyophilized Powder

Comment :

Contact Alomone Labs for technical support and product customization

UNSPSC :

41116134

Bioassay Tested :

Yes

Chemical Name :

5-(4-Chlorophenyl)-N-(3,5-dimethoxyphenyl)-2-furancarboxamide.

more info or order :

Alomone Labs product webpage