A 967079
Alomone Labs
catalog: A-225
citations: 1
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Ligustilide
Alomone Labs
catalog: L-170
citations: 1

Alomone Labs Ligustilide activates TRPA1 channels expressed in HEK-293 cells. - Dose-response curve for the activation of human TRPA1 expressing HEK-293 cells loaded with Calcium 5 dye for changes in intracellular Ca2+ measurements. Calcium signal was apparent with 200 M Ligustilide (#L-170).
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AP-18
Alomone Labs
catalog: A-250


Peptide (C)RRHEDWKRLARVMDR corresponding to amino acid residues 411-425 of rat nAChR?10 (AccessionQ9JLB5). 2ndintracellular loop.
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Curcumin
Alomone Labs
catalog: C-230


Alomone Labs Diazepam inhibits specific binding of Flunitrazepam to rat brain GABA(A) receptors. - Percent inhibition of the specific binding of 1 nM [3H]Flunitrazepam to membranes from whole rat brain (except cerebellum) was plotted against concentrations ofDiazepam(#D-215) (green circles) and of Diazepam standard (black squares) and used to calculate IC50and Ki values for Diazepam (IC50? 36 nM and Ki ? 29 nM).

Alomone Labs Curcumin activates TRPA1 channels expressed in HEK-293 cells. - Dose-response curve for the activation of human TRPA1 expressing HEK-293 cells loaded with Calcium 5 dye for changes in intracellular Ca2+measurements. Calcium signal was apparent with 100 MCurcumin(#C-230).
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Chembridge-5861528
Alomone Labs
catalog: C-235

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HC-030031
Alomone Labs
catalog: H-105

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Optovin
Alomone Labs
catalog: O-140


Alomone Labs Optovin activates TRPA1 channels expressed in HEK-293 cells. - Dose-response curve of the activation of human TRPA1 channels by increasing concentrations ofOptovin(#O-140). Cells were loaded with Calcium 5 dye. Changes in intracellular Ca2+following Optovin application were detected as changes in relative fluorescence (RFU). EC50was determined at 18.3 M.
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4-ONE
Alomone Labs
catalog: O-145


Alomone Labs PF-04856264 blocks NaV1.7 channels expressed in Xenopus oocytes. - A. Time course of NaV1.7 current amplitude and inhibition by 500 nMPF-04856264(#P-265). Currents were elicited by application of a 100 ms voltage step to 0 mV (H.P= -70mV to induce inactivation) every 10 seconds. B. Superimposed example traces of current responses before and during perfusion of 500 nM PF-04856264 as indicated.

Alomone Labs 4-ONE activates TRPA1 channels expressed in HEK-293 cells. - Dose response curve of the activation of human TRPA1 channels by increasing concentrations of4-ONE(#O-145). Cells were loaded with Calcium 5 dye. Changes in intracellular Ca2+following 4-ONE application were detected as changes in relative fluorescence (RFU). EC50was determined at 23.1 M.
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Wasabi Receptor Toxin
Alomone Labs
catalog: STW-200


ManufacturerBioassayAlomone Labs Wasabi receptor toxin leads to Ca2+ signals in HEK 293 cells transfected with TRPA1. - A. Upper, individual traces (grey) and mean trace (black) of changes in intracellular Ca2+ concentration with time (measured as a change in FURA-2AM fluorescent intensity) in HEK 293 cells transfected with human TRPA1, following application of 5 µM Wasabi receptor toxin (#STW-200) followed by 200 µM AITC. Bottom, Mean ± SEM of changes in intracellular Ca2+ in HEK 293 cells transfected with human TRPA1, following application of 5 µM Wasabi receptor toxin followed by 200 µM AITC. n = 42 cells, representative of 5 plates. B. Same as in A, but in untransfected HEK 293 cells. Ionomycin was added at the end of each experiment. n = 60 cells, representative of 3 plates.   Figure kindly provided by Prof. Alexander Binshtok, Dept. Medical Neurobiology, Institute for Medical Research, IMRIC, Hebrew University School of Medicine, Jerusalem.
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