Alomone Labs Cilnidipine blocks L-type CaVchannel currents expressed inXenopusoocytes. - A. Time course of CaV1.2 (co-expressed with ?2?1 and ?1 auxiliary subunits) current elicited by 100 ms voltage ramp from holding potential of -100 mV to +50 mV delivered every 10 seconds. Application of 10 MCilnidipine(#C-135) inhibits the current amplitude and modifies activation (see panel B. periods of application are indicated by the horizontal bars). B. Representative current traces before and during application of 10 M Cilnidipine as indicated.
Expression of Calnexin in mouse hippocampus - Immunohistochemical staining of mouse hippocampal CA1 region using Anti-CalnexinAntibody (#ACS-009) (1:200). A. Canx staining (green) appears in neurons (horizontal arrow) and astrocytes (vertical arrow). B. GFAP staining of astrocytic fibers (red). C. Merge of panels A and B demonstrates co-localization in some astrocytes. DAPI is used to stain nuclei (blue).
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Alomone Labs L-651582 blocks L-type Ca2+currents inXenopusoocytes. - A. Time course of L-type channel (CaV1.2+?2?1+?1a) activity before and during applications of 1 10 and 100 ?ML-651582(#L-110) and upon wash. Holding potential was -100 mV and currents were elicited every 10 seconds by 100 ms steps to 0 mV. Periods of compound application are indicated by symbols in the inset. B. Example of superimposed current traces before and during application of 1 10 and 100 ?M L-651582 (taken from the experiment described in A).
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Alomone Labs SR 33805 oxalate blocks L-type Ca2+ currents in Xenopus oocytes. - A. Time course of L-type channel (CaV1.2+?2?1+?1a) activity before and during applications of 1 ?MSR 33805 oxalate(#S-105) as indicated and upon wash. Holding potential was -80 mV and currents were elicited every 10 seconds by 100 ms ramp to +60 mV. B. Superimposed current traces of L-type currents before and during applications of 1 ?M SR 33805 oxalatetaken from the experiment in A.
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