ω-Conotoxin MVIIA
Alomone Labs
catalog: C-670
citations: 3

Peptide (C)REYSPAATTAENG corresponding to amino acid residues 7-19 of rat ATP1A2(AccessionP06686). Intracellular N-terminus.

Alomone Labs ?-Conotoxin MVIIA inhibits CaV2.2 heterologously expressed inXenopusoocytes. - A. Time course of?-Conotoxin MVIIA(#C-670) blocking action on CaV2.2 channels maximum current (expressing ?1B + ?2?1 + ?1 subunits). Maximum current amplitudes were plotted as a function of time. Membrane potential was held at -100 mV and oocytes were stimulated by a 100 ms voltage ramp to 60 mV. 50 nM ?-Conotoxin MVIIA was perfused as indicated by the bar (green) for 180 sec. B. Superimposed examples of CaV2.2 channel peak current in the absence (control) and presence (green) of 50 nM ?-Conotoxin MVIIA (taken from the experiment in A).
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PD 173212
Alomone Labs
catalog: P-105
citations: 1

Expression of DRD1in rat cortex - Immunohistochemical staining of perfusion-fixed frozen rat brain sectionsusing Guinea pigAnti-D1Dopamine ReceptorAntibody (#AGP-100) (1:300) followed by goat-anti-guinea pig-Cy3 antibody. DRD1staining (red) appears in neuronal soma (arrows). Nuclei are stained with DAPI (blue).

Alomone Labs PD 173212 blocks N-type Ca2+ currents in Xenopus oocytes. - A. Time course of N-type channel (CaV2.2+?2?1+?1a) activity before and during applications of 10 ?MPD 173212(#P-105) (green) and upon wash. Holding potential was -100 mV and currents were elicited every 10 seconds by 100 ms ramp to +60 mV. B. Superimposed example current traces (plotted against the corresponding ramp voltage) before and during application of 10 ?M PD 173212 in green (taken from the experiment described in A).
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ω-Conotoxin CVIA
Alomone Labs
catalog: STC-750
citations: 1

Peptide (C)GHSRLLNDTSAPHLE corresponding to amino acid residues 348 - 362 of rat KV1.4 (AccessionP15385). 1stextracellular loop.

Alomone Labs?-Conotoxin CVIA inhibits CaV2.2 channels expressed inXenopusoocytes. - A. Time course of?-Conotoxin CVIA(#STC-750) action on maximum CaV2.2 channels (?1B + ?2?1 + ?1) current elicited in 2 mM Ba2+. Peak current amplitudes were plotted as a function of time. Membrane potential was held at -100 mV and oocytes were stimulated by a 100 ms voltage step to 50 mV. 50 nM ?-Conotoxin CVIA was perfused as indicated by the bar (green) for 5 min. B. Superimposed examples of CaV2.2 channel maximum peak current in the absence (control) and presence (green) of 50 nM ?-Conotoxin CVIA (taken from the experiment in A).
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ω-Conotoxin CnVIIA
Alomone Labs
catalog: STC-800
citations: 1

Alomone Labs?-Conotoxin CnVIIA inhibits CaV2.2 channels heterologously expressed inXenopusoocytes. - A. Time course of?-Conotoxin CnVIIA(#STC-800) action on CaV2.2 + ?2?1 + ?1 currents. Peak current amplitude was plotted as a function of time. Membrane potential was held at -100 mV and oocytes were stimulated by a 100 ms voltage ramp to +50 mV. 1 M ?-Conotoxin CnVIIA (applied for 180 sec green) was perfused during the period marked by the bar as indicated and showed 75% inhibition of control current. B. Superimposed traces of channel current in the absence (black) and presence (green) of 1 M ?-Conotoxin CnVIIA (taken from experiment in A).
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Cilnidipine
Alomone Labs
catalog: C-135


Alomone Labs Cilnidipine blocks L-type CaVchannel currents expressed inXenopusoocytes. - A. Time course of CaV1.2 (co-expressed with ?2?1 and ?1 auxiliary subunits) current elicited by 100 ms voltage ramp from holding potential of -100 mV to +50 mV delivered every 10 seconds. Application of 10 MCilnidipine(#C-135) inhibits the current amplitude and modifies activation (see panel B. periods of application are indicated by the horizontal bars). B. Representative current traces before and during application of 10 M Cilnidipine as indicated.

Expression of Calnexin in mouse hippocampus - Immunohistochemical staining of mouse hippocampal CA1 region using Anti-CalnexinAntibody (#ACS-009) (1:200). A. Canx staining (green) appears in neurons (horizontal arrow) and astrocytes (vertical arrow). B. GFAP staining of astrocytic fibers (red). C. Merge of panels A and B demonstrates co-localization in some astrocytes. DAPI is used to stain nuclei (blue).
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L-651,582
Alomone Labs
catalog: L-110


Alomone Labs L-651582 blocks L-type Ca2+currents inXenopusoocytes. - A. Time course of L-type channel (CaV1.2+?2?1+?1a) activity before and during applications of 1 10 and 100 ?ML-651582(#L-110) and upon wash. Holding potential was -100 mV and currents were elicited every 10 seconds by 100 ms steps to 0 mV. Periods of compound application are indicated by symbols in the inset. B. Example of superimposed current traces before and during application of 1 10 and 100 ?M L-651582 (taken from the experiment described in A).
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ω-Conotoxin SVIB
Alomone Labs
catalog: STC-160


Western blot analysis of human MCF-7 breast adenocarcinoma cell lysate (lanes 1 and 3) and human LNCaP prostate adenocarcinoma cell lysate (lanes 2 and 4): - 12.Anti-ZIP3 (SLC39A3) Antibody(#AZT-003) (1:200).34. Anti-ZIP3 (SLC39A3) Antibody preincubated with the negative control antigen.
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ω-Conotoxin SO3
Alomone Labs
catalog: STC-470


Alomone Labs ?-Conotoxin SO3inhibits CaV2.2 channels heterologously expressed inXenopusoocytes. - A. Time course of?-Conotoxin SO3(#STC-470) blocking action on CaV2.2 currents (?1B + ?2?1+ ?1). Maximum current amplitude was plotted as a function of time. Membrane potential was held at -100 mV and cells were stimulated in the presence of 2 mM Ba2+by a 100 ms voltage ramp to +60 mV. 50 nM ?-Conotoxin SO3were perfused as indicated by the bar (green) during 150 s. B. Superimposed examples of CaV2.2 channel current in the absence (control) and presence (green) of 50 nM ?-Conotoxin SO3(taken from the experiment in A).
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ω-Conotoxin CVIE
Alomone Labs
catalog: STC-760


Western blot analysis of mouse brain lysate: - 1.Anti-KV1.4 (extracellular) Antibody (#APC-167) (1:200).2. Anti-KV1.4 (extracellular) Antibody preincubated with the negative control antigen.

Alomone Labs ?-Conotoxin CVIE blocks CaV2.2 currents heterologously expressed in Xenopus oocytes. - A. Time course of?-Conotoxin CVIE(#STC-760) blocking action on CaV2.2 currents elicited in 2 mM Ba2+. Maximum current amplitudes were plotted as a function of time. Membrane potential was held at -100 mV and cells were stimulated by a 100 ms voltage ramp to +50 mV. 10 nM ?-Conotoxin CVIE were perfused as indicated by the bar (green) during 5 min. B. Superimposed examples of CaV2.2 channel current in the absence (control) and presence (green) of 10 nM ?-Conotoxin CVIE (taken from the experiment in A).
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ω-Conotoxin CVIF
Alomone Labs
catalog: STC-770


Expression of KV1.4 in rat parietal cortex - Immunohistochemical staining of perfusion-fixed frozen rat brain sections using Anti-KV1.4 (extracellular)Antibody (#APC-167) (1:400) followed by donkey-anti-rabbit-biotin and streptavidin-Cy3. KV1.4 staining (red) appears in several neuronal-outlined cells (arrows). Nuclei were stained with DAPI (blue).

Alomone Labs?-Conotoxin CVIF inhibits CaV2.2 channel currents expressed inXenopusoocytes. - A. Time course of?-Conotoxin CVIF(#STC-770) action on maximum CaV2.2 channel (?1B + ?2?1 + ?1) current elicited in 2 mM Ba2+. Peak current amplitudes were plotted as a function of time. Membrane potential was held at -100 mV and oocytes were stimulated by a 100 ms voltage step to +40 mV. 50 nM ?-Conotoxin CVIF were perfused as indicated by the bar (green) for 2.5 min. B. Superimposed examples of CaV2.2 channel maximum peak current in the absence (control) and presence (green) of 50 nM ?-Conotoxin CVIF (taken from the experiment in A).
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ω-Conotoxin FVIA
Alomone Labs
catalog: STC-780


Expression of KV1.4 in live intact rat PC12 cells - Cell surface detection ofKV1.4 in live intact rat PC12 pheochromocytoma cells. A. Extracellular staining of cells withAnti-KV1.4 (extracellular) Antibody (#APC-167) (1:25) followed by goat anti-rabbit-AlexaFluor-555 secondary antibody (red). B. Live view of the cells. C. Merge of A and B.

Alomone Labs?-Conotoxin FVIA inhibits CaV2.2 channel expressed inXenopusoocytes. - A. Time course of?-Conotoxin FVIA(#STC-780) action on CaV2.2 (?1B + ?2?1 + ?1 subunits) maximum peak current amplitude. Peak current amplitudes were plotted as a function of time. Membrane potential was held at -100 mV and oocytes were stimulated by a 100 ms voltage ramp to +50 mV elicited in 2 mM Ba2+. 50 nM ?-Conotoxin FVIA was perfused as indicated by the bar (green) for 5 min. B. Superimposed examples of CaV2.2 channel maximum peak current in the absence (control) and presence (green) of 50 nM ?-Conotoxin FVIA (taken from the experiment in A).
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ω-Conotoxin RVIA
Alomone Labs
catalog: STC-850


Alomone Labs ?-Conotoxin RVIA inhibits CaV2.2 channels heterologously expressed inXenopusoocytes. - A. Time course of?-Conotoxin RVIA(#STC-850) action. Current amplitudes were plotted as a function of time. Holding potential was -80 mV and currents were stimulated every 10 seconds by a voltage ramp of 100 msec from holding potential to +60 mV. 1 M ?-Conotoxin RVIA was perfused in the period marked by the bar (green). B. Example traces of CaV2.2 currents before (black) and during (green) application of 1 M ?-Conotoxin RVIA.
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