citations: 76
Alomone Labs ?-Agatoxin IVA potently inhibits CaV2.1 channel currents expressed in HEK 293 cells. - CaV2.1 currents were elicited by 40 ms voltage ramp from a holding potential of -100 mV to +60 mV applied every 10 sec using whole-cell voltage clamp technique. Left: Superimposed traces of CaV2.1 currents under control conditions (black) and following 2 min perfusion with Alomone Labs 200 nM?-Agatoxin IVA(red). Right: Time course of CaV2.1 peak current amplitude change as a result of the application of 200 nM ?-Agatoxin IVA (duration of perfusion indicated by horizontal bar).
Alomone Labs FPL 64176 increases L-type CaVchannels currents expressed inXenopusoocytes. - A. Time course of CaV1.2 (co expressed with ?2?1 and ?1 auxiliary subunits) tail peak current amplitude elicited by 100 ms voltage step from holding potential of -100 mV to -10 mV delivered every 10 seconds. Application of 0.1 and 1 MFPL 64176(#F-160) increases the CaV1.2 current (indicated by the horizontal bar). B. Representative current traces before and during application of 0.1 and 1 M FPL 64176 (as indicated).
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citations: 12
Peptide CPEGEMGTYSHGIK corresponding to amino acid residues 136-149 of rat P2X6 receptor (AccessionP51579). Extracellular.
Alomone Labs ?-Agatoxin TK inhibits CaV2.1 channels heterologously expressed inXenopusoocytes. - A. Time course of?-Agatoxin TK(#STA-530) action on CaV2.1 currents. Maximum current amplitude was plotted as a function of time. Membrane potential was held at -100 mV and oocytes were stimulated by a 100 ms voltage ramp to +50 mV in the presence of 2 mM Ba2+. 1 M ?-Agatoxin TK was perfused as indicated by the bar for 300 s (green). B. Superimposed example of CaV2.1 channel current in the absence (control) and presence (green) of 1 M ?-Agatoxin TK (taken from the experiment in A).
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Alomone Labs FTX-3.3 blocks P-type Ca2+currents inXenopusoocytes. - A. Time course of P-type channel (CaV2.1+?2?1+?1a) activity before and during applications of 500 mMFTX-3.3(#F-120) and upon wash. Holding potential was -80 mV and currents were elicited every 10 seconds by 100 ms step to 0 mV. B. Superimposed current traces of P-type channels before and during applications of 500 ?M FTX-3.3 (taken from the experiment described in A).
Peptide SDYVNYDIIVRHYN(C) corresponding to amino acid residues 17-30 of human S1PR1 (AccessionP21453). Extracellular N-terminus.
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Alomone Labs sFTX-3.3 blocks P-type Ca2+currents inXenopusoocytes. - A. Time course of P-type channel (CaV2.1+a2d1+b1a) activity before and during applications of 500 ?MsFTX-3.3(#F-130) and upon wash. Holding potential was -80 mV and currents were elicited every 10 seconds by 100 ms step to 0 mV. B. Superimposed current traces of P-type channels before and during applications of 500 ?M sFTX-3.3 (taken from the experiment described in A).
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Alomone Labs L-651582 blocks L-type Ca2+currents inXenopusoocytes. - A. Time course of L-type channel (CaV1.2+?2?1+?1a) activity before and during applications of 1 10 and 100 ?ML-651582(#L-110) and upon wash. Holding potential was -100 mV and currents were elicited every 10 seconds by 100 ms steps to 0 mV. Periods of compound application are indicated by symbols in the inset. B. Example of superimposed current traces before and during application of 1 10 and 100 ?M L-651582 (taken from the experiment described in A).
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