Capsaicin
Alomone Labs
catalog: C-125
citations: 5

Alomone Labs Capsaicin induces Ca2+influx via activation of TRPV1 channels expressed in C6 cells. - Cells were loaded with Fluo-3 AM and stimulated withCapsaicin(#C-125). Changes in intracellular Ca2+were detected via changes in Fluo-3 emission following application. The left panel shows normalized fluorescence before and after application at 20 seconds of 0-10 M Capsaicin (as indicated). The right panel shows normalized fluorescence plotted against Capsaicin concentrations.

Peptide (C)KAEEDEILNRSPRNRK corresponding to amino acid residues 572-587 of rat Canx (AccessionP35565). Intracellular C-terminus.
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AMG 9810
Alomone Labs
catalog: A-180
citations: 2

Alomone Labs AMG 9810 inhibits Olvanil-activated TRPV1 channels heterologously expressed in C-6 cells - Cells were loaded with Fluo-3 AM and changes in intracellular Ca2+was measured. Normalized fluorescence before (control gray dotted line) and after application of 10 MOlvanil (#O-115) either without or after incubation with 1 M and 10 MAMG 9810(#A-180) black lines as indicated.

Peptide (C)KERDRYAYKIHLPE corresponding to amino acid residues 277-290 of mouse CASK (AccessionO70589). Intracellular.
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A-889425
Alomone Labs
catalog: A-195
citations: 2

Alomone Labs A-889425 inhibits capsaicin activated TRPV1 channels heterologously expressed in C-6 cells. - Cells were loaded with Fluo-3 AM and changes in intracellular Ca2+were measured. Normalized fluorescence before (control gray dotted line) and after application of 1Mcapsaicin(#C-125) (black lines) in cells pre-incubated without or with 0.5 MA-889425(#A-195) (top and bottom lines as indicated). 10 min pre-incubation with 0.5 M A-889425 abolishes capsaicin-evoked rise in intracellular Ca2+.

Expression of CASK in rat hypothalamus - Immunohistochemical staining of rat hypothalamus free floating frozen sections using Anti-CASKAntibody (#AIP-018) (1:200). CASK staining (green) appears in fibers with varicosities (arrows) running from the ventromedial hypothalamus (VMH) along the base of the brain. Nuclei are stained using DAPI (blue).
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BCTC
Alomone Labs
catalog: B-110
citations: 2
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Capsazepine
Alomone Labs
catalog: C-120
citations: 2

Western blot analysis of rat brain membrane (lane 1 and 3) mouse brain membrane (lanes 2 and 4) and human brain glioblastoma U87 MG cell line (lanes 5 and 6) lysate: - 125. Anti-LPAR1 (EDG2) (extracellular) Antibody(#ALR-031) (1:400).346. Anti-LPAR1 (EDG2) (extracellular) Antibody preincubated with the negative control antigen.

Alomone LabsCapsazepineinhibits TRPV1 channels expressed in C6 cells. - mTRPV1-C6 cells were loaded with Fluo-3AM. Changes in intracellular Ca2+were detected via changes in Fluo-3 emission following agonist application. 5 minutes pre-incubation with 10 MCapsazepine(#C-120) inhibited 10 MCapsaicin(#C-125)-evoked rise in intracellular Ca2+. Normalized fluorescence before and after application (arrow) of 10 M Capsaicin in cells pre-incubated without (black) or with 10 M Capsazepine (gray).
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5'-Iodoresiniferatoxin
Alomone Labs
catalog: I-800
citations: 3

Alomone Labs 5'-Iodoresiniferatoxin inhibits Capsaicin induced Ca2+influx via the activation of TRPV1 expressed in HEK-293 cells. - Cells were loaded with 1 mM fluo-3 AM and then stimulated with 10 M capsaicin in the absence (blue) or presence (purple) of 100 nM and 200 nM (green)5'-Iodoresiniferatoxin(#I-800). The figure shows intracellular Ca2+levels before and after stimulation of cells with 10 M capsaicin.
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Resiniferatoxin
Alomone Labs
catalog: R-400
citations: 2

Alomone Labs Resiniferatoxin induces Ca2+influx via activation of TRPV1 expressed in HEK293 cells. - Cells were loaded with 1mM fluo-3 AM and then stimulated withResiniferatoxin(#R-400). The left panel shows the intracellular Ca2+levels 10 sec post stimulation with different concentrations of Resiniferatoxin plotted against drug concentration (ED50= 2 M) . The right panel shows cytoplasmic Ca2+before and after stimulation of cells with 10 M Resiniferatoxin.
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SB-705498
Alomone Labs
catalog: S-160
citations: 1

Alomone Labs SB-705498 inhibits TRPV1 channels heterologously expressed in C-6 cells. - Cells were loaded with Fluo-3 AM and changes in intracellular Ca2+were detected. Normalized fluorescence of control cells (untreated and unstimulated) cells responding to 1MCapsaicin(#C-125) with or without pre-incubation with 10 MSB-705498(#S-160) as indicated.

Alomone Labs CGS 19755 inhibits NMDA (NR1+NR2A) receptors expressed inXenopusoocytes. - A. Time course of NMDA currents that were elicited by stimulation with 10 M glutamate and 10 M glycine every 50s while membrane potential was held at -80 mV. 0.1 1 and 10 MCGS 19755(#C-310) applied for 3 min as indicated inhibited current amplitude. B. Superimposed current traces taken from experiment described in A.
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Arvanil
Alomone Labs
catalog: A-335

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A 784168
Alomone Labs
catalog: A-345


Peptide (C)DSVSYEYGDYSDLSD corresponding to amino acid residues 4-18 of human C5a anaphylatoxin chemotactic receptor 2 (AccessionQ9P296). Extracellular N-terminus.
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6'-Iodoresiniferatoxin
Alomone Labs
catalog: I-805


Alomone Labs 6'-Iodoresiniferatoxin induces Ca2+influx via activation of TRPV1 expressed in HEK293 cells. - Cells were loaded with 2 mM fluo-3 AM and then stimulated with6?-Iodoresiniferatoxin(#I-805). The left panel shows the intracellular Ca2+levels 10 sec post stimulation with different concentrations of 6?-Iodoresiniferatoxin (ED50= 0.8 ?M) and plotted against drug concentration. The right panel shows intracellular Ca2+levels before and after stimulation of cells with 2.5 ?M 6?- Iodoresiniferatoxin.
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Nonivamide
Alomone Labs
catalog: N-220


Alomone Labs Nonivamideactivates TRPV1 channels heterologously expressed in C-6 cells. - Cells were loaded with Fluo-3 AM and changes in intracellular Ca2+were detected. Normalized fluorescence before (control gray dotted line) and after application of 0.1 1 and 10 MNonivamide(#N-220) (as indicated).
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Olvanil
Alomone Labs
catalog: O-115


Alomone Labs Olvanil activates TRPV1 channels heterologously expressed in C-6 cells. - Cells were loaded with Fluo-3 AM and changes in intracellular Ca2+were detected. Normalized fluorescence before and after application at 20 seconds (arrow) of 1 nM - 10 MOlvanil(#O-115) (as indicated).

Peptide (C)EKTLDLASVDLRK corresponding to amino acid residues 129-141 of human CDNF (AccessionQ49AH0). Mature CDNF protein.

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OLDA
Alomone Labs
catalog: O-120


Alomone Labs OLDA activates TRPV1 channels heterologously expressed in C-6 cells. - Cells were loaded with Fluo-3AM and changes in intracellular Ca2+were detected. Normalized fluorescence before (control) and after application at 20 seconds (arrow) of 1-100 MOLDA(#O-120) (as indicated).

Western blot analysis of 100 ng human recombinant CDNF (lanes 1 and 3) and 100 ng human recombinant MANF (lanes 2 and 4): - 12.Anti-CDNFAntibody (#ANT-027) (1:500).34. Anti-CDNF Antibody preincubated with the negative control antigen.Note that the antibody recognizes CDNF but fails to recognize closely related MANF.
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Palvanil
Alomone Labs
catalog: P-205


Alomone Labs Palvanil activates TRPV1 channels heterologously expressed in C6 cells. - Cells were loaded with Fluo-3 AM and changes in intracellular Ca2+were measured. Normalized fluorescence before (control gray dotted line) and after application of 0.1 and 1 MPalvanil(#P-205) (as indicated).
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SB-366791
Alomone Labs
catalog: S-180


Peptide (C)RQPSSPGPQPRNLSE corresponding to amino acid residues 191-205 of mouse ?1-syntrophin (AccessionQ61234). Intracellular PH1 domain.
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