citations: 324
Alomone Labs Tetrodotoxin citrateinhibits native NaVcurrents in ND7-23 cells. - Top: Time course of native inward current amplitude elicited from a holding potential of -100 mV by a 40 ms test pulse to -10 mV delivered every 15 sec. Application of 60 nM Tetrodotoxin citrate(#T-550) is marked in cyan blue. Bottom: Superimposed current traces before (blue) and during (cyan) bath perfusion of 60 nM TTX.
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citations: 23
Alomone Labs Tetrodotoxincitrate free inhibits native NaVcurrents in PC12 and ND7-23cells. - Tetrodotoxincitrate free(#T-500) inhibits PC12 (top) and ND7-23 (bottom) cells at a concentration of 60 nM. Left graphs show the time course of inward current amplitude upon bath application (marked by the horizontal bars) and wash of TTX. Membrane potential was clamped to -120 mV and currents were elicited by 20 ms test pulses to -10 or -20 mV (upper and lower graphs respectively) delivered every 10 sec. Right graphs show the superimposed traces of control current (red) and during perfusion of TTX (black).
Alomone LabsChembridge-5861528inhibitsAllyl isothiocyanate induced calcium signal in TRPA1 expressing cells. - Dose-response curve for the inhibition of human TRPA1 expressing HEK-293 cells loaded with Calcium 5 dye for changes in intracellular Ca2+ measurements. Allyl isothiocyanate (100 M)-induced calcium signal was inhibited by 5 M Chembridge-5861528 (#C-235) with estimated IC50 of about 4 M.
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Alomone Labs Phencyclidine hydrochloride inhibits NMDA receptor channels (NR1+NR2A) expressed inXenopusoocytes. - A. Time course of NMDAR currents elicited by transient stimulations with 100 M glutamate and 100 M glycine every 100s while membrane potential was held at -80 mV. 0.5 MPhencyclidine hydrochloride(#P-125) applied for 8 min (bar) significantly inhibited current amplitude. B. Superimposed current traces from the recording shown in A upon application of control and of 0.5 M Phencyclidine hydrochloride (as indicated).
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Alomone Labs Co 102862 inhibits NaV1.7 channel currents in HEK293cells. - A. Time course of current reversible inhibition by 50 MCo 102862(#C-160). Currents were elicited by a voltage ramp from a holding potential of -100 mV to 60 mV (30 ms) delivered every 10 seconds. B. Example traces of current response to voltage ramp stimulation before and during application of 50 M Co 102862.
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