Iberiotoxin
Alomone Labs
catalog: STI-400
citations: 59

Alomone Labs Iberiotoxin inhibits KCa1.1 channels (mSlo)heterologously expressed inXenopusoocytes. - A. Time course of KCa1.1 channel current amplitude before (black) during (green marked by horizontal bar) application of 100 nMIberiotoxin(#STI-400) for 200 sec and upon wash of the toxin. Currents were elicited every 10 sec by ramp stimulation to +100 mV from a holding of ?100 mV for 100 msec. B. Superimposed example current responses before (black) and during (green) application of 100 nM Iberiotoxin (taken from the experiment in A).

Alomone Labs Alosetron hydrochloride blocks 5HT3A receptors expressed in HEK 293T cells. - 5-HT3A receptor currents were elicited with 10 M 5-HT delivered every 3 minutes. Alosetron hydrochloride (#A-236) was applied 30 seconds before stimulation at 1 10 and 100 nM as indicated and completely inhibited the 5-HT induced current in a dose-dependent and reversible manner.
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Paxilline
Alomone Labs
catalog: P-450
citations: 21

Alomone Labs Paxilline inhibits KCa1.1 (BK) channels heterologously expressed in Xenopus oocytes. - Left: The effect of 100 nMPaxilline(#P-450) (a)Penitrem A(P-650) (b) andVerruculogen(#V-500) (c) on BK currents. Time course of current amplitude changes upon sequential application of the three toxins. Right: Example of current responses to 100 ms depolarization before (red) and during (black) perfusion of 500 nM Paxilline.

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Charybdotoxin
Alomone Labs
catalog: STC-325
citations: 25

Expression of NaV1.3 in HEK-293 transfected cells - Cell surface detection ofNaV1.3 in intact living HEK-293 cells expressing rat NaV1.3. A. Extracellular staining of cells usingAnti-SCN3A (NaV1.3) (extracellular)Antibody (#ASC-023) (red). B. Cells transfected with the empty vector show no NaV1.3 staining. Nuclear staining using DAPI as the counterstain (blue).

Alomone LabsCharybdotoxin inhibits KCa1.1 channels heterologously expressed inXenopusoocytes. - A. Example of time course showing reversible effect of 20 nM and 50 nM Charybdotoxin (#STC-325) during 100 sec application on the current amplitude. Membrane holding potential was -100 mV stepped to 0 mV during 200 ms following another step to 80 mV during 600 msec. B. Superimposed example traces of KCa1.1 channel currents in response to ramp depolarization before (Control) and during the application of 20 nM or 50 nM of Charybdotoxin for 100 sec.
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Penitrem A
Alomone Labs
catalog: P-650
citations: 7

Alomone Labs Penitrem A inhibits KCa1.1 (BK) channels heterologously expressed inXenopusoocytes. - The effect of 100 nMPaxilline(#P-450) (a)Penitrem A(#P-650) (b) andVerruculogen(#V-500) (c) on BK currents. Time course of current amplitude changes upon sequential application of the three toxins.

Western blot analysis of rat testis (lanes 1 and 4) and kidney lysates (lanes 2 and 5) and heart membrane (lanes 3 and 6): - 1-3. Anti-MRS2 Antibody(#ANT-148) (1:400).4-6. Anti-MRS2 Antibody preincubated with the negative control antigen.
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Verruculogen
Alomone Labs
catalog: V-500
citations: 6

Verruculogen inhibits KCa1.1 channels inXenopusoocytes. - Time course of KCa1.1 channel current amplitude upon application of several mycotoxins includingVerruculogen(#V-500). Current amplitude was reduced by 100 nMPaxilline(#P-450) (a)Penitrem A(#P-650) (b) and Verruculogen (c). The horizontal bars represent the period of toxin perfusion.
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1-EBIO
Alomone Labs
catalog: E-150
citations: 3
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Isopimaric Acid
Alomone Labs
catalog: I-370
citations: 2

Alomone Labs Isopimaric Acid was tested inXenopusoocytes expressing mSlo(BK) channel using TEVC recordings. - Time course of BK channel amplitudes by applying 100 ?MIsopimaric Acid(#I-370). Currents were elicited by a 150 ms pulse that was increased stepwise every 30 ms from +10 mV to +50 mV from a holding potential of -100 mV. Pulses were delivered every 10 sec. Pulses were normalized to the values of controls.

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NS19504
Alomone Labs
catalog: N-235
citations: 1

Alomone LabsNS19504enhances KCa1.1 channels expressed inXenopusoocytes. - A. Time course of KCa1.1 channel activity at 55 mV demonstrating the effect of 10 and 50 ?MNS19504(#N-235). B. Representative current traces under control conditions and following application of 10 and 50 ?M NS19504. Currents were elicited by a 100 ms voltage ramp from -80 to 80 mV every 10 seconds from a holding potential of -100 mV (current responses are shown between -40 and 80 mV).
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Pimaric Acid
Alomone Labs
catalog: P-270
citations: 1

Alomone Labs Pimaric Acid was tested inXenopusoocytes expressing KCa1.1 channel using TEVC recordings. - Left: Time course of KCa1.1 channel amplitude by applying 50 MPimaric Acid(#P-270) and 200 nMCharybdotoxin(#STC-325) (ChTx). Currents were elicited by a 100 ms pulse to 0 mV from holding potential of -100 mV. Pulses were delivered every 10 seconds. The bars at the top indicate the period of the indicated drug application. Currents were normalized to the values of controls. The red green and blue symbols mark the traces that are shown on the right. Right: Example traces of control (red) Pimaric Acid activated (green) and Charybdotoxin (ChTx) inhibited (blue). KCa1.1 currents are taken from the experiment shown on the left.

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Tanshinone II-A sodium sulfonate
Alomone Labs
catalog: T-165


Alomone LabsBCTCblocks TRPV1 channels expressed in C6 cells. - Pre-incubation with 0.1 nM 1 nM and 10 nMBCTC(#B-110) as indicated inhibits the 1 Mcapsaicin(#C-125)-evoked rise in intracellular Ca2+(control). mTRPV1-C6 cells were loaded with Fluo-3-AM. Changes in intracellular Ca2+were detected as changes in Fluo-3 fluorescent emission following agonist application.

Alomone Labs Tanshinone II-A sodium sulfonate enhances KCa1.1 channels expressed inXenopusoocytes. - A. Time course of KCa1.1 channel activity at 40 mV demonstrating the effect of 100 ?MTanshinone II-A sodium sulfonate(#T-165). B. Representative current traces under control conditions and following application of 100 ?M Tanshinone II-A sodium sulfonate. Currents were elicited by a 100 ms voltage ramp from -100 to 60 mV every 10 seconds from a holding potential of -100 mV (current responses are shown between 0 and 60 mV).
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