citations: 22
Alomone Labs Tertiapin-Q inhibits Kir3.2 channel heterologously expressed inXenopusoocytes. - A continuous current trace recorded at a holding potential of -80 mV. Kir3.2 currents are downward reflections activated by high K+containing solution. While activated increasing concentrations ofTertiapin-Q(#STT-170) were applied (arrows at the bottom of the trace).
Li+modulates GIRK activity in hippocampal neurons. - Incubation of neurons with 1 mM Li+ increased Ibasalin low-K+solution. Ibasalwas measured at ?120 mV (voltage step from the holding potential of ?60 mV) to enhance the sensitivity of measurement. Representative traces recorded in the low-K+solution before (black) and after (pink) application ofTertiapin-Q(#STT-170).Adapted fromFarhy Tselnicker I.et al.(2014) with permission ofProceedings of the National Academy of Sciences.
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Alomone Labs A 967079 inhibits Allyl isothiocyanate induced calcium signal in TRPA1 expressing cells. - Dose-response curve for the inhibition of human TRPA1 expressing HEK-293 cells loaded with Calcium 5 dye for changes in intracellular Ca2+measurements.Allyl isothiocyanate (100 M)-induced calcium signal was completely inhibited by 0.5 M A 967079 (#A-225) with an estimated IC50 of about 120 nM.
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