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Alomone Labs 11-Dimethyl-4-phenylpiperazinium iodide activates muscle fetal ?1/?1/?/? nAChR heterologously expressed inXenopusoocytes. - A. Time course of current repetitive and reversible activation by 100 M11-Dimethyl-4-phenylpiperazinium iodide(#D-125). Holding potential was -60 mV and currents were elicited by application of 100 M acetylcholine. B. Example traces of current responses to 10 mM or 100 mM acetylcholine as indicated.
Alomone Labs WS 12 activates TRPM8 channels expressed in HEK-293 cells. - Dose response curve for the activation of human TRPM8 by rising concentrations ofWS 12(#W-105) showing activity at low nanomolar range. Cells were loaded with Calcium-5 dye. Changes in intracellular Ca2+were detected as changes in 485 nm/525 nm fluorescence following agonist application.
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Alomone Labs DMAB-anabaseine dihydrochloride inhibits ?7 nicotinic acetylcholine receptors heterologously expressed inXenopusoocytes. - A. Current traces of ?7 nicotinic acetylcholine receptor activity at -60 mV holding potential. Currents were elicited by application of 100 M acetylcholine every 50 seconds. Inhibition of these induced currents was achieved upon perfusion of 1 or 10 MDMAB-anabaseine dihydrochloride(#D-110) (indicated by horizontal bars). B. Superimposed current responses to the application of either 100 M acetylcholine (Ach) or 100 M DMAB-anabaseine dihydrochloride (Ana) demonstrating the partial agonist effect on ?7 channels.
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Alomone LabsKynurenic acidinhibits NMDA (NR1+NR2A) channels expressed inXenopusoocytes. - A. Time course of NMDA currents elicited by stimulation with 100 M glutamate and 100 M glycine every 50 sec while membrane potential was held at -80 mV. 100 and 250 MKynurenic acid(#K-110) applied for 3 min each reversibly inhibited current amplitude. B. Superimposed current traces taken from the experiment described in A.
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