citations: 1
Alomone Labs 11-Dimethyl-4-phenylpiperazinium iodide activates muscle fetal ?1/?1/?/? nAChR heterologously expressed inXenopusoocytes. - A. Time course of current repetitive and reversible activation by 100 M11-Dimethyl-4-phenylpiperazinium iodide(#D-125). Holding potential was -60 mV and currents were elicited by application of 100 M acetylcholine. B. Example traces of current responses to 10 mM or 100 mM acetylcholine as indicated.
Alomone Labs WS 12 activates TRPM8 channels expressed in HEK-293 cells. - Dose response curve for the activation of human TRPM8 by rising concentrations ofWS 12(#W-105) showing activity at low nanomolar range. Cells were loaded with Calcium-5 dye. Changes in intracellular Ca2+were detected as changes in 485 nm/525 nm fluorescence following agonist application.
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Alomone Labs Hexamethonium bromide blocks ?3/?4 nAChR heterologously expressed inXenopusoocytes. - Time course of current reversible inhibition by 10 20 and 40 MHexamethonium bromide(#H-100). Holding potential was -80 mV and inward current was elicited by continuous application of 2 M acetylcholine (period of application is indicated by the horizontal bar on top).
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Alomone LabsKynurenic acidinhibits NMDA (NR1+NR2A) channels expressed inXenopusoocytes. - A. Time course of NMDA currents elicited by stimulation with 100 M glutamate and 100 M glycine every 50 sec while membrane potential was held at -80 mV. 100 and 250 MKynurenic acid(#K-110) applied for 3 min each reversibly inhibited current amplitude. B. Superimposed current traces taken from the experiment described in A.
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Alomone Labs Mecamylamine hydrochloride reversibly inhibits nicotinic receptors heterologously expressed inXenopusoocytes. - A. Time course of the inhibitory effect of 1 and 10 MMecamylamine hydrochloride(#M-105) on ?7 nicotinic currents elicited at -80 mV holding potential by continuous stimulation with 100 M ACh + 3 MPNU 282987(#P-110) every 50 sec (indicated by uppermost horizontal bars). B. Superimposed traces of channel activity before and during application of the indicated Mecamylamine hydrochloride concentrations (taken from the experiment shown in panel A).
Alomone Labs Amentoflavone inhibits specific binding of Flunitrazepam to rat brain GABA(A) receptors. - Percent inhibition of specific binding of 1 nM [3H]Flunitrazepam to membranes from whole rat brain (except cerebellum) was plotted against concentrations ofAmentoflavone(#A-165) (green circles) and of Diazepam (assay standard black squares) and used to calculate IC50and Ki values for Amentoflavone (IC50? 4.95 nM and Ki ? 4.03nM).
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