Anti-GLO1 Glyoxalase I (clone 6F10) | Agrisera AS21 4568 product information

product summary

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company name :

Agrisera

product type :

antibody

product name :

Anti-GLO1 Glyoxalase I (clone 6F10)

catalog :

AS21 4568

quantity :

100 µg

price :

361 USD

clonality :

monoclonal

host :

rat

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot, ELISA, immunocytochemistry

more info or order :

Agrisera product webpage

citations: 3

Reference
Jiang L, Wang J, Wang Z, Huang W, Yang Y, Cai Z, et al. Role of the Glyoxalase System in Alzheimer's Disease. J Alzheimers Dis. 2018;66:887-899 pubmed publisher
Hovatta I, Tennant R, Helton R, Marr R, Singer O, Redwine J, et al. Glyoxalase 1 and glutathione reductase 1 regulate anxiety in mice. Nature. 2005;438:662-6 pubmed
Junaid M, Kowal D, Barua M, Pullarkat P, Sklower Brooks S, Pullarkat R. Proteomic studies identified a single nucleotide polymorphism in glyoxalase I as autism susceptibility factor. Am J Med Genet A. 2004;131:11-7 pubmed

product information

Catalog Number :

AS21 4568

Product Name :

Anti-GLO1 Glyoxalase I (clone 6F10)

Product Type :

Primary antibody

Host Species :

Rat

Clonality :

Monoclonal

Size :

100 µg

List Price (EUR) :

361 USD

list of Pubmed id :

Q9CPU0

Product Description :

Glyoxalase I (GLO1) is an enzyme that plays a role in the detoxification of methylglyoxal (MG), a side-product of glycolysis, via condensation with glutathione to produce S-lactoyl-glutathione. GLO1 is a zinc metalloenzyme whose crystal structure has been solved. The bacterial and yeast enzymes are monomeric while the mammalian one is homodimeric and its sequence is well conserved. GLO1 is found over-expressed in some tumors. GLO1 has also been suggested to be involved in anxiety diseases, autism, and Alzheimer s disease.

CrossReactivity :

Human, simian, mouse

Background :

Glyoxalase I (GLO1) is an enzyme that plays a role in the detoxification of methylglyoxal (MG), a side-product of glycolysis, via condensation with glutathione to produce S-lactoyl-glutathione. GLO1 is a zinc metalloenzyme whose crystal structure has been solved. The bacterial and yeast enzymes are monomeric while the mammalian one is homodimeric and its sequence is well conserved. GLO1 is found over-expressed in some tumors. GLO1 has also been suggested to be involved in anxiety diseases, autism, and Alzheimer s disease.

Immunogen :

Recombinant, full-length mouse GLO1 UniProt: Q9CPU0 fused to GST

Purity :

Proprietary affinity chromatography in PBS. Contains 50% glycerol, filter sterilized.

Uses :

ELISA (ELISA), Immunofluorescence (IF), Western blot (WB)

Application Summary :

ELISA (ELISA), Immunofluorescence (IF), Western blot (WB)

Storage :

Store at -20°C; make aliquots to avoid repeated freeze-thaw cycles. Please remember to spin the tubes briefly prior to opening them to avoid any losses that might occur from material adhering to the cap or sides of the tube.

more info or order :

Agrisera product webpage