product summary
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company name :
Agrisera
product type :
antibody
product name :
ASyO5 Mouse anti-human alpha-synuclein oligomer-specific (clone number 2.4)
catalog :
AS13 2718
quantity :
50 µg
price :
597 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
2.4
more info or order :
Agrisera product webpage
citations: 6
Reference
Limegrover C, Yurko R, Izzo N, LaBarbera K, Rehak C, Look G, et al. Sigma-2 receptor antagonists rescue neuronal dysfunction induced by Parkinson's patient brain-derived α-synuclein. J Neurosci Res. 2021;99:1161-1176 pubmed publisher
Kilpeläinen T, Julku U, Svarcbahs R, Myöhänen T. Behavioural and dopaminergic changes in double mutated human A30P*A53T alpha-synuclein transgenic mouse model of Parkinson´s disease. Sci Rep. 2019;9:17382 pubmed publisher
Svarcbahs R, Julku U, Norrbacka S, Myöhänen T. Removal of prolyl oligopeptidase reduces alpha-synuclein toxicity in cells and in vivo. Sci Rep. 2018;8:1552 pubmed publisher
Wu K, Liou H, Kao Y, Lee C, Lin C. The critical role of Nramp1 in degrading α-synuclein oligomers in microglia under iron overload condition. Neurobiol Dis. 2017;104:61-72 pubmed publisher
Svarcbahs R, Julku U, Myöhänen T. Inhibition of Prolyl Oligopeptidase Restores Spontaneous Motor Behavior in the ?-Synuclein Virus Vector-Based Parkinson's Disease Mouse Model by Decreasing ?-Synuclein Oligomeric Species in Mouse Brain. J Neurosci. 2016;36:12485-12497 pubmed
Brannstrom K, Lindhagen Persson M, Gharibyan A, Iakovleva I, Vestling M, Sellin M, et al. A generic method for design of oligomer-specific antibodies. PLoS ONE. 2014;9:e90857 pubmed publisher
product information
Catalog Number :
AS13 2718
NY :
NEJ
Product Name :
ASyO5 Mouse anti-human alpha-synuclein oligomer-specific (clone number 2.4)
Product Type :
Primary
Host Species :
Mouse
Clonality :
Monoclonal
Conjugation :
Unconjugated
Clone Name :
clone 2.4
Size :
50 µg
List Price :
597 USD
Background :
Alpha-synuclein is normally an unstructured soluble protein that can aggregate to form insoluble fibrils in pathological conditions characterized by Lewy bodies, such as Parkinson's disease, dementia with Lewy-bodies, and multiple system atrophy, In analogy to many other amyloid associated disorders, alpha-synuclein may also form oligomeric assemblies, These small and soluble forms have been suggested to exert a stronger tissue damaging effect as compared to the monomeric and fibrillar counterpart, Using a recently developed technique a monoclonal oligomer-specific antibody has been designed,
Immunogen :
synthetic peptide derived from human alpha-synuclein Gly111-Tyr125
Purity :
Affinity purified in PBS pH 7,4, no preservatives
Storage :
For short time storage add sodium azide and store at +4°C, For long time storage store lyophilized/reconstituted at -20°C; once reconstituted make aliquots to avoid repeated freeze-thaw cycles, Please, remember to spin tubes briefly prior to opening them to avoid any losses that might occur from lyophilized material adhering to the cap or sides of the tubes,
more info or order :
Agrisera product webpage
company information
Agrisera
Box 57
911 21 Vannas
info@agrisera.com
https://www.agrisera.com
46 935-330000
headquarters: Sweden
Agrisera is a Swedish company specializing in polyclonal and monoclonal antibody production, offering primary and secondary antibodies off-the-shelf. Agrisera offers an extensive list of antibodies suitable for detection of plant and algal proteins in a wide range of research areas and applications. They are reactive in thousands of plant and algal species and cited in thousands of scientific articles. Agrisera was awarded as the Plant Science Antibody Supplier of the Year by CiteAB for the company with the most antibody citations for research related to plant science during 2018.