Anti-ASyO5 Mouse anti-human alpha-synuclein oligomer-specific (clone number 2,4)

product summary

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company name :

Agrisera

product type :

antibody

product name :

Anti-ASyO5 Mouse anti-human alpha-synuclein oligomer-specific (clone number 2,4)

catalog :

AS13 2718

quantity :

50 µg

price :

672.00 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

IgG1

application :

ELISA, immunohistochemistry, dot blot

more info or order :

Agrisera product webpage

citations: 6

Reference
Limegrover C, Yurko R, Izzo N, LaBarbera K, Rehak C, Look G, et al. Sigma-2 receptor antagonists rescue neuronal dysfunction induced by Parkinson's patient brain-derived α-synuclein. J Neurosci Res. 2021;99:1161-1176 pubmed publisher
Kilpeläinen T, Julku U, Svarcbahs R, Myöhänen T. Behavioural and dopaminergic changes in double mutated human A30P*A53T alpha-synuclein transgenic mouse model of Parkinson´s disease. Sci Rep. 2019;9:17382 pubmed publisher
Svarcbahs R, Julku U, Norrbacka S, Myöhänen T. Removal of prolyl oligopeptidase reduces alpha-synuclein toxicity in cells and in vivo. Sci Rep. 2018;8:1552 pubmed publisher
Wu K, Liou H, Kao Y, Lee C, Lin C. The critical role of Nramp1 in degrading Î±-synuclein oligomers in microglia under iron overload condition. Neurobiol Dis. 2017;104:61-72 pubmed publisher
Svarcbahs R, Julku U, Myöhänen T. Inhibition of Prolyl Oligopeptidase Restores Spontaneous Motor Behavior in the ?-Synuclein Virus Vector-Based Parkinson's Disease Mouse Model by Decreasing ?-Synuclein Oligomeric Species in Mouse Brain. J Neurosci. 2016;36:12485-12497 pubmed
Brannstrom K, Lindhagen Persson M, Gharibyan A, Iakovleva I, Vestling M, Sellin M, et al. A generic method for design of oligomer-specific antibodies. PLoS ONE. 2014;9:e90857 pubmed publisher

product information

Catalog Number :

AS13 2718

Product Name :

Anti-ASyO5 Mouse anti-human alpha-synuclein oligomer-specific (clone number 2,4)

Product Type :

Primary antibody

Host Species :

Mouse

Clonality :

Monoclonal

Size :

50 µg

List Price :

672.00 USD

Product Description :

Alpha-synuclein is normally an unstructured soluble protein that can aggregate to form insoluble fibrils in pathological conditions characterized by Lewy bodies, such as Parkinson's disease, dementia with Lewy-bodies, and multiple system atrophy. In analogy to many other amyloid associated disorders, alpha-synuclein may also form oligomeric assemblies. These small and soluble forms have been suggested to exert a stronger tissue damaging effect as compared to the monomeric and fibrillar counterpart. Using a recently developed technique a monoclonal oligomer-specific antibody has been designed.

CrossReactivity :

Human, mouse

Background :

Alpha-synuclein is normally an unstructured soluble protein that can aggregate to form insoluble fibrils in pathological conditions characterized by Lewy bodies, such as Parkinson's disease, dementia with Lewy-bodies, and multiple system atrophy. In analogy to many other amyloid associated disorders, alpha-synuclein may also form oligomeric assemblies. These small and soluble forms have been suggested to exert a stronger tissue damaging effect as compared to the monomeric and fibrillar counterpart. Using a recently developed technique a monoclonal oligomer-specific antibody has been designed.

Immunogen :

Synthetic peptide derived from human alpha-synuclein Gly111-Tyr125

Purity :

Immunogen affinity purified serum in PBS pH 7.4.

Uses :

Dot blot (Dot), ELISA (ELISA), Immunohistochemistry (IHC)

Application Summary :

Dot blot (Dot), ELISA (ELISA), Immunohistochemistry (IHC)

Storage :

For short time storage add sodium azide and store at +4°C. For long time storage store lyophilized/reconstituted at -20°C; once reconstituted make aliquots to avoid repeated freeze-thaw cycles. Please remember to spin the tubes briefly prior to opening them to avoid any losses that might occur from material adhering to the cap or sides of the tube.

more info or order :

Agrisera product webpage