Published Application/Species/Sample/Dilution | Reference |
---|
- western blot knockout validation; mouse; loading ...; fig 2a
| Chen Y, Qin X, An Q, Yi J, Feng F, Yin D, et al. Mesenchymal Stromal Cells Directly Promote Inflammation by Canonical NLRP3 and Non-canonical Caspase-11 Inflammasomes. EBioMedicine. 2018;32:31-42 pubmed publisher
|
- western blot knockout validation; mouse; 1 ug/ml; loading ...; fig 1f
| Antonopoulos C, Russo H, El Sanadi C, Martin B, Li X, Kaiser W, et al. Caspase-8 as an Effector and Regulator of NLRP3 Inflammasome Signaling. J Biol Chem. 2015;290:20167-84 pubmed publisher
|
- western blot; mouse; 1:50; fig s10g
| Ising C, Venegas C, Zhang S, Scheiblich H, Schmidt S, Vieira Saecker A, et al. NLRP3 inflammasome activation drives tau pathology. Nature. 2019;: pubmed publisher
|
- western blot; mouse; 1:100; loading ...; fig 1b
| Samir P, Kesavardhana S, Patmore D, Gingras S, Malireddi R, Karki R, et al. DDX3X acts as a live-or-die checkpoint in stressed cells by regulating NLRP3 inflammasome. Nature. 2019;573:590-594 pubmed publisher
|
- western blot; mouse; loading ...; fig 1e
| Huang X, Feng Z, Jiang Y, Li J, Xiang Q, Guo S, et al. VSIG4 mediates transcriptional inhibition of Nlrp3 and Il-1β in macrophages. Sci Adv. 2019;5:eaau7426 pubmed publisher
|
- western blot; human; loading ...; fig 2j
- western blot; mouse; loading ...; fig 2a
| Zhang C, Jiang M, Zhou H, Liu W, Wang C, Kang Z, et al. TLR-stimulated IRAKM activates caspase-8 inflammasome in microglia and promotes neuroinflammation. J Clin Invest. 2018;128:5399-5412 pubmed publisher
|
- western blot; mouse; loading ...; fig 2h
| Li F, Li Y, Liang H, Xu T, Kong Y, Huang M, et al. HECTD3 mediates TRAF3 polyubiquitination and type I interferon induction during bacterial infection. J Clin Invest. 2018;128:4148-4162 pubmed publisher
|
- western blot; mouse; loading ...; fig 3b
| Qu W, Wang Y, Wu Y, Liu Y, Chen K, Liu X, et al. Triggering Receptors Expressed on Myeloid Cells 2 Promotes Corneal Resistance Against Pseudomonas aeruginosa by Inhibiting Caspase-1-Dependent Pyroptosis. Front Immunol. 2018;9:1121 pubmed publisher
|
- western blot; mouse; loading ...; fig 2a
| Malireddi R, Gurung P, Mavuluri J, Dasari T, Klco J, Chi H, et al. TAK1 restricts spontaneous NLRP3 activation and cell death to control myeloid proliferation. J Exp Med. 2018;215:1023-1034 pubmed publisher
|
- western blot; mouse; loading ...; fig 7e
| Czimmerer Z, Dániel B, Horvath A, Rückerl D, Nagy G, Kiss M, et al. The Transcription Factor STAT6 Mediates Direct Repression of Inflammatory Enhancers and Limits Activation of Alternatively Polarized Macrophages. Immunity. 2018;48:75-90.e6 pubmed publisher
|
- western blot; mouse; 1:1000; loading ...; fig 1a
- western blot; human; 1:1000; loading ...; fig 1f
| Tang T, Lang X, Xu C, Wang X, Gong T, Yang Y, et al. CLICs-dependent chloride efflux is an essential and proximal upstream event for NLRP3 inflammasome activation. Nat Commun. 2017;8:202 pubmed publisher
|
- western blot; mouse; loading ...; fig 4g
| Domingo Fernández R, Coll R, Kearney J, Breit S, O Neill L. The intracellular chloride channel proteins CLIC1 and CLIC4 induce IL-1? transcription and activate the NLRP3 inflammasome. J Biol Chem. 2017;292:12077-12087 pubmed publisher
|
- western blot; mouse; fig 2b
| Leal Lasarte M, Franco J, Labrador Garrido A, Pozo D, Roodveldt C. Extracellular TDP-43 aggregates target MAPK/MAK/MRK overlapping kinase (MOK) and trigger caspase-3/IL-18 signaling in microglia. FASEB J. 2017;31:2797-2816 pubmed publisher
|
- western blot; mouse; 1:1000; loading ...; fig 2b
| Thurston T, Matthews S, Jennings E, Alix E, Shao F, Shenoy A, et al. Growth inhibition of cytosolic Salmonella by caspase-1 and caspase-11 precedes host cell death. Nat Commun. 2016;7:13292 pubmed publisher
|
- western blot; mouse; 1:1000; fig 2
| Wang X, Shaw D, Hammond H, Sutterwala F, Rayamajhi M, Shirey K, et al. The Prostaglandin E2-EP3 Receptor Axis Regulates Anaplasma phagocytophilum-Mediated NLRC4 Inflammasome Activation. PLoS Pathog. 2016;12:e1005803 pubmed publisher
|
- western blot; mouse; 1 ug/ml; fig 5A
| Russo H, Rathkey J, Boyd Tressler A, Katsnelson M, Abbott D, Dubyak G. Active Caspase-1 Induces Plasma Membrane Pores That Precede Pyroptotic Lysis and Are Blocked by Lanthanides. J Immunol. 2016;197:1353-67 pubmed publisher
|
- western blot; mouse; 1:4000; fig 6
| Dick M, Sborgi L, Rühl S, Hiller S, Broz P. ASC filament formation serves as a signal amplification mechanism for inflammasomes. Nat Commun. 2016;7:11929 pubmed publisher
|
- western blot; mouse; 1:1000; fig 6
| Wang X, Shaw D, Sakhon O, Snyder G, Sundberg E, Santambrogio L, et al. The Tick Protein Sialostatin L2 Binds to Annexin A2 and Inhibits NLRC4-Mediated Inflammasome Activation. Infect Immun. 2016;84:1796-1805 pubmed publisher
|
- western blot; mouse; fig 3
| Ravindran R, Loebbermann J, Nakaya H, Khan N, Ma H, Gama L, et al. The amino acid sensor GCN2 controls gut inflammation by inhibiting inflammasome activation. Nature. 2016;531:523-527 pubmed publisher
|
| Chen F, Jiang G, Liu H, Li Z, Pei Y, Wang H, et al. Melatonin alleviates intervertebral disc degeneration by disrupting the IL-1β/NF-κB-NLRP3 inflammasome positive feedback loop. Bone Res. 2020;8:10 pubmed publisher
|
| Guo H, Liu H, Jian Z, Cui H, Fang J, Zuo Z, et al. Nickel induces inflammatory activation via NF-κB, MAPKs, IRF3 and NLRP3 inflammasome signaling pathways in macrophages. Aging (Albany NY). 2019;11:11659-11672 pubmed publisher
|
| Hughes M, Hooftman A, Angiari S, Tummala P, Zaslona Z, Runtsch M, et al. Glutathione Transferase Omega-1 Regulates NLRP3 Inflammasome Activation through NEK7 Deglutathionylation. Cell Rep. 2019;29:151-161.e5 pubmed publisher
|
| Vande Walle L, Stowe I, Sácha P, Lee B, Demon D, Fossoul A, et al. MCC950/CRID3 potently targets the NACHT domain of wild-type NLRP3 but not disease-associated mutants for inflammasome inhibition. PLoS Biol. 2019;17:e3000354 pubmed publisher
|
| Hornick E, Dagvadorj J, Zacharias Z, Miller A, Langlois R, Chen P, et al. Dendritic cell NLRC4 regulates influenza A virus-specific CD4 T cell responses through FasL expression. J Clin Invest. 2019;129:2888-2897 pubmed publisher
|
| Sandstrom A, Mitchell P, Goers L, Mu E, Lesser C, Vance R. Functional degradation: A mechanism of NLRP1 inflammasome activation by diverse pathogen enzymes. Science. 2019;364: pubmed publisher
|
| Briard B, Karki R, Malireddi R, Bhattacharya A, Place D, Mavuluri J, et al. Fungal ligands released by innate immune effectors promote inflammasome activation during Aspergillus fumigatus infection. Nat Microbiol. 2019;4:316-327 pubmed publisher
|
| Sharma D, Malik A, Guy C, Vogel P, Kanneganti T. TNF/TNFR axis promotes pyrin inflammasome activation and distinctly modulates pyrin inflammasomopathy. J Clin Invest. 2019;129:150-162 pubmed publisher
|
| Mouhadeb O, Ben Shlomo S, Cohen K, Farkash I, Gruber S, Maharshak N, et al. Impaired COMMD10-Mediated Regulation of Ly6Chi Monocyte-Driven Inflammation Disrupts Gut Barrier Function. Front Immunol. 2018;9:2623 pubmed publisher
|
| Kasper L, König A, Koenig P, Gresnigt M, Westman J, Drummond R, et al. The fungal peptide toxin Candidalysin activates the NLRP3 inflammasome and causes cytolysis in mononuclear phagocytes. Nat Commun. 2018;9:4260 pubmed publisher
|
| Chen H, Fang Y, Wu J, Chen H, Zou Z, Zhang X, et al. RIPK3-MLKL-mediated necroinflammation contributes to AKI progression to CKD. Cell Death Dis. 2018;9:878 pubmed publisher
|
| Zhang Y, Rong H, Zhang F, Wu K, Mu L, Meng J, et al. A Membrane Potential- and Calpain-Dependent Reversal of Caspase-1 Inhibition Regulates Canonical NLRP3 Inflammasome. Cell Rep. 2018;24:2356-2369.e5 pubmed publisher
|
| de la Roche M, Hamilton C, Mortensen R, Jeyaprakash A, Ghosh S, Anand P. Trafficking of cholesterol to the ER is required for NLRP3 inflammasome activation. J Cell Biol. 2018;217:3560-3576 pubmed publisher
|
| Zhong Z, Liang S, Sanchez Lopez E, He F, Shalapour S, Lin X, et al. New mitochondrial DNA synthesis enables NLRP3 inflammasome activation. Nature. 2018;560:198-203 pubmed publisher
|
| Lang T, Lee J, Elgass K, Pinar A, Tate M, Aitken E, et al. Macrophage migration inhibitory factor is required for NLRP3 inflammasome activation. Nat Commun. 2018;9:2223 pubmed publisher
|
| Kanneganti A, Malireddi R, Saavedra P, Vande Walle L, Van Gorp H, Kambara H, et al. GSDMD is critical for autoinflammatory pathology in a mouse model of Familial Mediterranean Fever. J Exp Med. 2018;215:1519-1529 pubmed publisher
|
| Karki R, Lee E, Place D, Samir P, Mavuluri J, Sharma B, et al. IRF8 Regulates Transcription of Naips for NLRC4 Inflammasome Activation. Cell. 2018;173:920-933.e13 pubmed publisher
|
| Place D, Samir P, Karki R, Briard B, Vogel P, Kanneganti T. ASK Family Kinases Are Required for Optimal NLRP3 Inflammasome Priming. Am J Pathol. 2018;188:1021-1030 pubmed publisher
|
| Kuriakose T, Zheng M, Neale G, Kanneganti T. IRF1 Is a Transcriptional Regulator of ZBP1 Promoting NLRP3 Inflammasome Activation and Cell Death during Influenza Virus Infection. J Immunol. 2018;200:1489-1495 pubmed publisher
|
| Costa Franco M, Marim F, Guimarães E, Assis N, Cerqueira D, Alves Silva J, et al. Brucella abortus Triggers a cGAS-Independent STING Pathway To Induce Host Protection That Involves Guanylate-Binding Proteins and Inflammasome Activation. J Immunol. 2018;200:607-622 pubmed publisher
|
| He Y, She H, Zhang T, Xu H, Cheng L, Yepes M, et al. p38 MAPK inhibits autophagy and promotes microglial inflammatory responses by phosphorylating ULK1. J Cell Biol. 2018;217:315-328 pubmed publisher
|
| Wang W, Shi Q, Dou S, Li G, Shi X, Jiang X, et al. Negative regulation of Nod-like receptor protein 3 inflammasome activation by T cell Ig mucin-3 protects against peritonitis. Immunology. 2018;153:71-83 pubmed publisher
|
| Van Opdenbosch N, Van Gorp H, Verdonckt M, Saavedra P, de Vasconcelos N, Gonçalves A, et al. Caspase-1 Engagement and TLR-Induced c-FLIP Expression Suppress ASC/Caspase-8-Dependent Apoptosis by Inflammasome Sensors NLRP1b and NLRC4. Cell Rep. 2017;21:3427-3444 pubmed publisher
|
| Swanson K, Junkins R, Kurkjian C, Holley Guthrie E, Pendse A, El Morabiti R, et al. A noncanonical function of cGAMP in inflammasome priming and activation. J Exp Med. 2017;214:3611-3626 pubmed publisher
|
| Jiang H, He H, Chen Y, Huang W, Cheng J, Ye J, et al. Identification of a selective and direct NLRP3 inhibitor to treat inflammatory disorders. J Exp Med. 2017;214:3219-3238 pubmed publisher
|
| Cheng K, Xiong S, Ye Z, Hong Z, Di A, Tsang K, et al. Caspase-11-mediated endothelial pyroptosis underlies endotoxemia-induced lung injury. J Clin Invest. 2017;127:4124-4135 pubmed publisher
|
| Song N, Liu Z, Xue W, Bai Z, Wang Q, Dai J, et al. NLRP3 Phosphorylation Is an Essential Priming Event for Inflammasome Activation. Mol Cell. 2017;68:185-197.e6 pubmed publisher
|
| Ghosh S, Wallerath C, Covarrubias S, Hornung V, Carpenter S, Fitzgerald K. The PYHIN Protein p205 Regulates the Inflammasome by Controlling Asc Expression. J Immunol. 2017;199:3249-3260 pubmed publisher
|
| Yoon S, Kovalenko A, Bogdanov K, Wallach D. MLKL, the Protein that Mediates Necroptosis, Also Regulates Endosomal Trafficking and Extracellular Vesicle Generation. Immunity. 2017;47:51-65.e7 pubmed publisher
|
| Traba J, Geiger S, Kwarteng Siaw M, Han K, Ra O, Siegel R, et al. Prolonged fasting suppresses mitochondrial NLRP3 inflammasome assembly and activation via SIRT3-mediated activation of superoxide dismutase 2. J Biol Chem. 2017;292:12153-12164 pubmed publisher
|
| Yang A, Inamine T, Hochrath K, Chen P, Wang L, Llorente C, et al. Intestinal fungi contribute to development of alcoholic liver disease. J Clin Invest. 2017;127:2829-2841 pubmed publisher
|
| Conos S, Chen K, De Nardo D, Hara H, Whitehead L, Núñez G, et al. Active MLKL triggers the NLRP3 inflammasome in a cell-intrinsic manner. Proc Natl Acad Sci U S A. 2017;114:E961-E969 pubmed publisher
|
| Kuchmiy A, D Hont J, Hochepied T, Lamkanfi M. NLRP2 controls age-associated maternal fertility. J Exp Med. 2016;213:2851-2860 pubmed
|
| Qi X, Man S, Malireddi R, Karki R, Lupfer C, Gurung P, et al. Cathepsin B modulates lysosomal biogenesis and host defense against Francisella novicida infection. J Exp Med. 2016;213:2081-97 pubmed publisher
|
| Van Opdenbosch N, Gurung P, Vande Walle L, Fossoul A, Kanneganti T, Lamkanfi M. Activation of the NLRP1b inflammasome independently of ASC-mediated caspase-1 autoproteolysis and speck formation. Nat Commun. 2014;5:3209 pubmed publisher
|