Published Application/Species/Sample/Dilution | Reference |
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- western blot knockout validation; mouse; loading ...; fig 1g
| Chen Y, Qin X, An Q, Yi J, Feng F, Yin D, et al. Mesenchymal Stromal Cells Directly Promote Inflammation by Canonical NLRP3 and Non-canonical Caspase-11 Inflammasomes. EBioMedicine. 2018;32:31-42 pubmed publisher
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- western blot knockout validation; mouse; 1:1000; loading ...; fig 5e
- immunoprecipitation; mouse; loading ...; fig 8b
| Tang T, Lang X, Xu C, Wang X, Gong T, Yang Y, et al. CLICs-dependent chloride efflux is an essential and proximal upstream event for NLRP3 inflammasome activation. Nat Commun. 2017;8:202 pubmed publisher
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- western blot knockout validation; human; loading ...; fig s1b
| Gutierrez K, Davis M, Daniels B, Olsen T, Ralli Jain P, Tait S, et al. MLKL Activation Triggers NLRP3-Mediated Processing and Release of IL-1β Independently of Gasdermin-D. J Immunol. 2017;198:2156-2164 pubmed publisher
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- western blot knockout validation; mouse; loading ...; fig 3b
| Wang Y, Yan X, Mi S, Li Z, Wang Y, Zhu H, et al. Naoxintong attenuates Ischaemia/reperfusion Injury through inhibiting NLRP3 inflammasome activation. J Cell Mol Med. 2017;21:4-12 pubmed publisher
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- western blot knockout validation; mouse; loading ...; fig s7
| de Torre Minguela C, Barberà Cremades M, Gómez A, MartÃn Sánchez F, PelegrÃn P. Macrophage activation and polarization modify P2X7 receptor secretome influencing the inflammatory process. Sci Rep. 2016;6:22586 pubmed publisher
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- western blot; mouse; loading ...; fig 1e
| Sharma D, Malik A, Guy C, Vogel P, Kanneganti T. TNF/TNFR axis promotes pyrin inflammasome activation and distinctly modulates pyrin inflammasomopathy. J Clin Invest. 2019;129:150-162 pubmed publisher
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- western blot; mouse; loading ...; fig 3b
| Qu W, Wang Y, Wu Y, Liu Y, Chen K, Liu X, et al. Triggering Receptors Expressed on Myeloid Cells 2 Promotes Corneal Resistance Against Pseudomonas aeruginosa by Inhibiting Caspase-1-Dependent Pyroptosis. Front Immunol. 2018;9:1121 pubmed publisher
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- western blot; mouse; loading ...; fig 7e
| Czimmerer Z, Dániel B, Horvath A, Rückerl D, Nagy G, Kiss M, et al. The Transcription Factor STAT6 Mediates Direct Repression of Inflammatory Enhancers and Limits Activation of Alternatively Polarized Macrophages. Immunity. 2018;48:75-90.e6 pubmed publisher
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- western blot; human; 1:1000; loading ...; fig s1b
| Bednash J, Weathington N, Londino J, Rojas M, Gulick D, Fort R, et al. Targeting the deubiquitinase STAMBP inhibits NALP7 inflammasome activity. Nat Commun. 2017;8:15203 pubmed publisher
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- western blot; mouse; loading ...; fig 3c
| Koh H, Kim Y, Kim J, Yun J, Jang K, Yang C. Toxoplasma gondii GRA7-Targeted ASC and PLD1 Promote Antibacterial Host Defense via PKCα. PLoS Pathog. 2017;13:e1006126 pubmed publisher
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- immunoprecipitation; mouse; fig 4
| Du R, Wu F, Lu M, Shu X, Ding J, Wu G, et al. Uncoupling protein 2 modulation of the NLRP3 inflammasome in astrocytes and its implications in depression. Redox Biol. 2016;9:178-187 pubmed publisher
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- immunoprecipitation; human; 1:50; loading ...; fig 6i
| Mortimer L, Moreau F, MacDonald J, Chadee K. NLRP3 inflammasome inhibition is disrupted in a group of auto-inflammatory disease CAPS mutations. Nat Immunol. 2016;17:1176-86 pubmed publisher
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- immunocytochemistry; human; 1:200; fig 1
- western blot; human; 1:200; fig 1
| De Filippis L, Halikere A, McGowan H, Moore J, Tischfield J, Hart R, et al. Ethanol-mediated activation of the NLRP3 inflammasome in iPS cells and iPS cells-derived neural progenitor cells. Mol Brain. 2016;9:51 pubmed publisher
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- western blot; human; fig 1
| Ezekwe E, Weng C, Duncan J. ADAM10 Cell Surface Expression but Not Activity Is Critical for Staphylococcus aureus ?-Hemolysin-Mediated Activation of the NLRP3 Inflammasome in Human Monocytes. Toxins (Basel). 2016;8:95 pubmed publisher
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- western blot; mouse; 1:100; loading ...; fig 5e
| MartÃn Sánchez F, Diamond C, Zeitler M, Gómez A, Baroja Mazo A, Bagnall J, et al. Inflammasome-dependent IL-1β release depends upon membrane permeabilisation. Cell Death Differ. 2016;23:1219-31 pubmed publisher
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- western blot; human; loading ...; fig 5c
- western blot; mouse; loading ...; fig 3a
| Haque S, Lan X, Wen H, Lederman R, Chawla A, Attia M, et al. HIV Promotes NLRP3 Inflammasome Complex Activation in Murine HIV-Associated Nephropathy. Am J Pathol. 2016;186:347-58 pubmed publisher
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- western blot; human; loading ...; fig 1c
| Viganò E, Diamond C, Spreafico R, Balachander A, Sobota R, Mortellaro A. Human caspase-4 and caspase-5 regulate the one-step non-canonical inflammasome activation in monocytes. Nat Commun. 2015;6:8761 pubmed publisher
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- western blot; rat; 1:1000; loading ...; fig 5a
| Mocanu A, Mulya A, Huang H, Dan O, Shimizu H, Batayyah E, et al. Effect of Roux-en-Y Gastric Bypass on the NLRP3 Inflammasome in Adipose Tissue from Obese Rats. PLoS ONE. 2015;10:e0139764 pubmed publisher
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- immunocytochemistry; mouse; 1:100
| Bruchard M, Rebé C, Derangère V, Togbé D, Ryffel B, Boidot R, et al. The receptor NLRP3 is a transcriptional regulator of TH2 differentiation. Nat Immunol. 2015;16:859-70 pubmed publisher
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- immunohistochemistry - paraffin section; rat; 1:200
| Kono S, Kurata T, Sato K, Omote Y, Hishikawa N, Yamashita T, et al. Neurovascular protection by telmisartan via reducing neuroinflammation in stroke-resistant spontaneously hypertensive rat brain after ischemic stroke. J Stroke Cerebrovasc Dis. 2015;24:537-47 pubmed publisher
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| Ortiz F, Acuña Castroviejo D, Doerrier C, Dayoub J, López L, Venegas C, et al. Melatonin blunts the mitochondrial/NLRP3 connection and protects against radiation-induced oral mucositis. J Pineal Res. 2015;58:34-49 pubmed publisher
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| Derangère V, Chevriaux A, Courtaut F, Bruchard M, Berger H, Chalmin F, et al. Liver X receptor ? activation induces pyroptosis of human and murine colon cancer cells. Cell Death Differ. 2014;21:1914-24 pubmed publisher
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| Chen F, Jiang G, Liu H, Li Z, Pei Y, Wang H, et al. Melatonin alleviates intervertebral disc degeneration by disrupting the IL-1β/NF-κB-NLRP3 inflammasome positive feedback loop. Bone Res. 2020;8:10 pubmed publisher
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| Samir P, Kesavardhana S, Patmore D, Gingras S, Malireddi R, Karki R, et al. DDX3X acts as a live-or-die checkpoint in stressed cells by regulating NLRP3 inflammasome. Nature. 2019;573:590-594 pubmed publisher
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| Du R, Lu M, Wang C, Ding J, Wu G, Hu G. The pore-forming subunit Kir6.1 of the K-ATP channel negatively regulates the NLRP3 inflammasome to control insulin resistance by interacting with NLRP3. Exp Mol Med. 2019;51:92 pubmed publisher
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| Davis M, Fairgrieve M, den Hartigh A, Yakovenko O, Duvvuri B, Lood C, et al. Calpain drives pyroptotic vimentin cleavage, intermediate filament loss, and cell rupture that mediates immunostimulation. Proc Natl Acad Sci U S A. 2019;116:5061-5070 pubmed publisher
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| Huang X, Feng Z, Jiang Y, Li J, Xiang Q, Guo S, et al. VSIG4 mediates transcriptional inhibition of Nlrp3 and Il-1β in macrophages. Sci Adv. 2019;5:eaau7426 pubmed publisher
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| Mehto S, Jena K, Nath P, Chauhan S, Kolapalli S, Das S, et al. The Crohn's Disease Risk Factor IRGM Limits NLRP3 Inflammasome Activation by Impeding Its Assembly and by Mediating Its Selective Autophagy. Mol Cell. 2019;73:429-445.e7 pubmed publisher
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| Kiyohara H, Sujino T, Teratani T, Miyamoto K, Arai M, Nomura E, et al. Toll-Like Receptor 7 Agonist-Induced Dermatitis Causes Severe Dextran Sulfate Sodium Colitis by Altering the Gut Microbiome and Immune Cells. Cell Mol Gastroenterol Hepatol. 2019;7:135-156 pubmed publisher
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| Hafner Bratkovic I, Sušjan P, Lainšček D, Tapia Abellán A, Cerović K, Kadunc L, et al. NLRP3 lacking the leucine-rich repeat domain can be fully activated via the canonical inflammasome pathway. Nat Commun. 2018;9:5182 pubmed publisher
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| Tyagi A, Nguyen C, Chong T, Michel C, Fritz K, Reisdorph N, et al. SIRT3 deficiency-induced mitochondrial dysfunction and inflammasome formation in the brain. Sci Rep. 2018;8:17547 pubmed publisher
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| Xu C, Lu Z, Luo Y, Liu Y, Cao Z, Shen S, et al. Targeting of NLRP3 inflammasome with gene editing for the amelioration of inflammatory diseases. Nat Commun. 2018;9:4092 pubmed publisher
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| Zhang Y, Rong H, Zhang F, Wu K, Mu L, Meng J, et al. A Membrane Potential- and Calpain-Dependent Reversal of Caspase-1 Inhibition Regulates Canonical NLRP3 Inflammasome. Cell Rep. 2018;24:2356-2369.e5 pubmed publisher
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| Barry R, John S, Liccardi G, Tenev T, Jaco I, Chen C, et al. SUMO-mediated regulation of NLRP3 modulates inflammasome activity. Nat Commun. 2018;9:3001 pubmed publisher
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| de la Roche M, Hamilton C, Mortensen R, Jeyaprakash A, Ghosh S, Anand P. Trafficking of cholesterol to the ER is required for NLRP3 inflammasome activation. J Cell Biol. 2018;217:3560-3576 pubmed publisher
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| Zhong Z, Liang S, Sanchez Lopez E, He F, Shalapour S, Lin X, et al. New mitochondrial DNA synthesis enables NLRP3 inflammasome activation. Nature. 2018;560:198-203 pubmed publisher
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| Mouton Liger F, Rosazza T, Sepulveda Diaz J, Ieang A, Hassoun S, Claire E, et al. Parkin deficiency modulates NLRP3 inflammasome activation by attenuating an A20-dependent negative feedback loop. Glia. 2018;: pubmed publisher
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| Tang T, Lv L, Pan M, Wen Y, Wang B, Li Z, et al. Hydroxychloroquine attenuates renal ischemia/reperfusion injury by inhibiting cathepsin mediated NLRP3 inflammasome activation. Cell Death Dis. 2018;9:351 pubmed publisher
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| Malireddi R, Gurung P, Mavuluri J, Dasari T, Klco J, Chi H, et al. TAK1 restricts spontaneous NLRP3 activation and cell death to control myeloid proliferation. J Exp Med. 2018;215:1023-1034 pubmed publisher
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| Liu J, Mustafa S, Barratt D, Hutchinson M. Corticosterone Preexposure Increases NF-κB Translocation and Sensitizes IL-1β Responses in BV2 Microglia-Like Cells. Front Immunol. 2018;9:3 pubmed publisher
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| Clift D, McEwan W, Labzin L, Konieczny V, Mogessie B, James L, et al. A Method for the Acute and Rapid Degradation of Endogenous Proteins. Cell. 2017;171:1692-1706.e18 pubmed publisher
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| Swanson K, Junkins R, Kurkjian C, Holley Guthrie E, Pendse A, El Morabiti R, et al. A noncanonical function of cGAMP in inflammasome priming and activation. J Exp Med. 2017;214:3611-3626 pubmed publisher
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| Jiang H, He H, Chen Y, Huang W, Cheng J, Ye J, et al. Identification of a selective and direct NLRP3 inhibitor to treat inflammatory disorders. J Exp Med. 2017;214:3219-3238 pubmed publisher
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| Song N, Liu Z, Xue W, Bai Z, Wang Q, Dai J, et al. NLRP3 Phosphorylation Is an Essential Priming Event for Inflammasome Activation. Mol Cell. 2017;68:185-197.e6 pubmed publisher
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| Khalafalla M, Woods L, Camden J, Khan A, Limesand K, Petris M, et al. P2X7 receptor antagonism prevents IL-1? release from salivary epithelial cells and reduces inflammation in a mouse model of autoimmune exocrinopathy. J Biol Chem. 2017;292:16626-16637 pubmed publisher
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| Traba J, Geiger S, Kwarteng Siaw M, Han K, Ra O, Siegel R, et al. Prolonged fasting suppresses mitochondrial NLRP3 inflammasome assembly and activation via SIRT3-mediated activation of superoxide dismutase 2. J Biol Chem. 2017;292:12153-12164 pubmed publisher
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| Cannito S, Morello E, Bocca C, Foglia B, Benetti E, Novo E, et al. Microvesicles released from fat-laden cells promote activation of hepatocellular NLRP3 inflammasome: A pro-inflammatory link between lipotoxicity and non-alcoholic steatohepatitis. PLoS ONE. 2017;12:e0172575 pubmed publisher
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| Conos S, Chen K, De Nardo D, Hara H, Whitehead L, Núñez G, et al. Active MLKL triggers the NLRP3 inflammasome in a cell-intrinsic manner. Proc Natl Acad Sci U S A. 2017;114:E961-E969 pubmed publisher
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| Wei C, Wang Y, Du Z, Guan K, Cao Y, Yang H, et al. The Yersinia Type III secretion effector YopM Is an E3 ubiquitin ligase that induced necrotic cell death by targeting NLRP3. Cell Death Dis. 2016;7:e2519 pubmed publisher
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| Zhang Z, Du X, Ma X, Zong Y, Chen J, Yu C, et al. Activation of the NLRP3 inflammasome in lipopolysaccharide-induced mouse fatigue and its relevance to chronic fatigue syndrome. J Neuroinflammation. 2016;13:71 pubmed publisher
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| Zhao J, Mou Y, Bernstock J, Klimanis D, Wang S, Spatz M, et al. Synthetic Oligodeoxynucleotides Containing Multiple Telemeric TTAGGG Motifs Suppress Inflammasome Activity in Macrophages Subjected to Oxygen and Glucose Deprivation and Reduce Ischemic Brain Injury in Stroke-Prone Spontaneously Hypertensive Rats. PLoS ONE. 2015;10:e0140772 pubmed publisher
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| Gurung P, Li B, Subbarao Malireddi R, Lamkanfi M, Geiger T, Kanneganti T. Chronic TLR Stimulation Controls NLRP3 Inflammasome Activation through IL-10 Mediated Regulation of NLRP3 Expression and Caspase-8 Activation. Sci Rep. 2015;5:14488 pubmed publisher
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| Mortimer L, Moreau F, Cornick S, Chadee K. The NLRP3 Inflammasome Is a Pathogen Sensor for Invasive Entamoeba histolytica via Activation of α5β1 Integrin at the Macrophage-Amebae Intercellular Junction. PLoS Pathog. 2015;11:e1004887 pubmed publisher
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| Dos Santos G, Rogel M, Baker M, Troken J, Urich D, Morales Nebreda L, et al. Vimentin regulates activation of the NLRP3 inflammasome. Nat Commun. 2015;6:6574 pubmed publisher
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| Yang C, Kim J, Kim T, Lee P, Kim S, Lee H, et al. Small heterodimer partner interacts with NLRP3 and negatively regulates activation of the NLRP3 inflammasome. Nat Commun. 2015;6:6115 pubmed publisher
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| Yoshida K, Yoshioka M, Okamura H, Moriyama S, Kawazoe K, Grenier D, et al. Preventive effect of Daiokanzoto (TJ-84) on 5-fluorouracil-induced human gingival cell death through the inhibition of reactive oxygen species production. PLoS ONE. 2014;9:e112689 pubmed publisher
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| Vande Walle L, Van Opdenbosch N, Jacques P, Fossoul A, Verheugen E, Vogel P, et al. Negative regulation of the NLRP3 inflammasome by A20 protects against arthritis. Nature. 2014;512:69-73 pubmed publisher
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| Park Y, Yoon S, Suh H, Kim D, Park J, Jung H, et al. TXNIP deficiency exacerbates endotoxic shock via the induction of excessive nitric oxide synthesis. PLoS Pathog. 2013;9:e1003646 pubmed publisher
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