| Published Application/Species/Sample/Dilution | Reference |
|---|
- western blot knockout validation; mouse; fig 4
| Shi H, Wang Y, Li X, Zhan X, Tang M, Fina M, et al. NLRP3 activation and mitosis are mutually exclusive events coordinated by NEK7, a new inflammasome component. Nat Immunol. 2016;17:250-8 pubmed publisher |
- western blot; mouse; loading ...; fig 3e
| Kim Y, Kim J, Gu S, Jo S, Kim S, Young Kim S, et al. Identification of highly potent and selective inhibitor, TIPTP, of the p22phox-Rubicon axis as a therapeutic agent for rheumatoid arthritis. Sci Rep. 2020;10:4570 pubmed publisher |
- western blot; mouse; 1:1000; loading ...; fig 2f
| Wooff Y, Fernando N, Wong J, Dietrich C, Aggio Bruce R, Chu Tan J, et al. Caspase-1-dependent inflammasomes mediate photoreceptor cell death in photo-oxidative damage-induced retinal degeneration. Sci Rep. 2020;10:2263 pubmed publisher |
- proximity ligation assay; mouse; loading ...; fig 3b
- western blot; mouse; loading ...; fig s3e
| Dumont A, de Rosny C, Kieu T, Perrey S, Berger H, Fluckiger A, et al. Docosahexaenoic acid inhibits both NLRP3 inflammasome assembly and JNK-mediated mature IL-1β secretion in 5-fluorouracil-treated MDSC: implication in cancer treatment. Cell Death Dis. 2019;10:485 pubmed publisher |
- western blot; human; loading ...; fig 1d
| Sharif H, Wang L, Wang W, Magupalli V, Andreeva L, Qiao Q, et al. Structural mechanism for NEK7-licensed activation of NLRP3 inflammasome. Nature. 2019;: pubmed publisher |
- western blot; mouse; loading ...; fig 1b
| Huang X, Feng Z, Jiang Y, Li J, Xiang Q, Guo S, et al. VSIG4 mediates transcriptional inhibition of Nlrp3 and Il-1β in macrophages. Sci Adv. 2019;5:eaau7426 pubmed publisher |
- western blot; mouse; loading ...; fig 2k
| Kiyohara H, Sujino T, Teratani T, Miyamoto K, Arai M, Nomura E, et al. Toll-Like Receptor 7 Agonist-Induced Dermatitis Causes Severe Dextran Sulfate Sodium Colitis by Altering the Gut Microbiome and Immune Cells. Cell Mol Gastroenterol Hepatol. 2019;7:135-156 pubmed publisher |
- immunohistochemistry; mouse; 1:1000; loading ...; fig 7a
- western blot; mouse; 1:2000; loading ...; fig 1d
| de la Roche M, Hamilton C, Mortensen R, Jeyaprakash A, Ghosh S, Anand P. Trafficking of cholesterol to the ER is required for NLRP3 inflammasome activation. J Cell Biol. 2018;217:3560-3576 pubmed publisher |
- western blot; human; loading ...; fig s16b
| Lau A, Chung H, Komada T, Platnich J, Sandall C, Choudhury S, et al. Renal immune surveillance and dipeptidase-1 contribute to contrast-induced acute kidney injury. J Clin Invest. 2018;128:2894-2913 pubmed publisher |
- western blot; human; 1:500; fig 2b
| Lagrange B, Benaoudia S, Wallet P, Magnotti F, Provost A, Michal F, et al. Human caspase-4 detects tetra-acylated LPS and cytosolic Francisella and functions differently from murine caspase-11. Nat Commun. 2018;9:242 pubmed publisher |
- western blot; mouse; loading ...; fig s17b
| Fuster J, MacLauchlan S, Zuriaga M, Polackal M, Ostriker A, Chakraborty R, et al. Clonal hematopoiesis associated with TET2 deficiency accelerates atherosclerosis development in mice. Science. 2017;355:842-847 pubmed publisher |
- immunohistochemistry - paraffin section; mouse; loading ...; fig 6c
- immunoprecipitation; mouse; loading ...; fig 3g
- western blot; mouse; loading ...; fig 5c
- immunoprecipitation; human; loading ...; fig 3c
| Wei C, Wang Y, Du Z, Guan K, Cao Y, Yang H, et al. The Yersinia Type III secretion effector YopM Is an E3 ubiquitin ligase that induced necrotic cell death by targeting NLRP3. Cell Death Dis. 2016;7:e2519 pubmed publisher |
- immunocytochemistry; human; fig s5
| Burgy O, Bellaye P, Causse S, Beltramo G, Wettstein G, Boutanquoi P, et al. Pleural inhibition of the caspase-1/IL-1? pathway diminishes profibrotic lung toxicity of bleomycin. Respir Res. 2016;17:162 pubmed |
- EMSA; human; fig 5g
- immunoprecipitation; human; fig s8c
- immunocytochemistry; human; 1:100; fig 5a
- western blot; human; 1:1000; fig 5e
| Ambite I, Puthia M, Nagy K, Cafaro C, Nadeem A, Butler D, et al. Molecular Basis of Acute Cystitis Reveals Susceptibility Genes and Immunotherapeutic Targets. PLoS Pathog. 2016;12:e1005848 pubmed publisher |
- western blot; mouse; 1:1000; loading ...; fig 1d
- western blot; human; 1:1000; loading ...; fig 6i
| Mortimer L, Moreau F, MacDonald J, Chadee K. NLRP3 inflammasome inhibition is disrupted in a group of auto-inflammatory disease CAPS mutations. Nat Immunol. 2016;17:1176-86 pubmed publisher |
- flow cytometry; human; loading ...; fig 2d
- immunocytochemistry; human; loading ...; fig 1e
| Arbore G, West E, Spolski R, Robertson A, Klos A, Rheinheimer C, et al. T helper 1 immunity requires complement-driven NLRP3 inflammasome activity in CD4⺠T cells. Science. 2016;352:aad1210 pubmed publisher |
- immunoprecipitation; human; fig 1
- western blot; human; fig 1
| He Y, Zeng M, Yang D, Motro B, Núñez G. NEK7 is an essential mediator of NLRP3 activation downstream of potassium efflux. Nature. 2016;530:354-7 pubmed publisher |
- western blot; mouse; loading ...; fig s6a
| Kayagaki N, Stowe I, Lee B, O Rourke K, Anderson K, Warming S, et al. Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling. Nature. 2015;526:666-71 pubmed publisher |
- immunoprecipitation; human; loading ...; fig 1e
- western blot; human; loading ...; fig 1e
| Giguère P, Gall B, Ezekwe E, Laroche G, Buckley B, Kebaier C, et al. G Protein signaling modulator-3 inhibits the inflammasome activity of NLRP3. J Biol Chem. 2014;289:33245-57 pubmed publisher |
- western blot; human; loading ...; fig 3a
| Huck O, Elkaim R, Davideau J, Tenenbaum H. Porphyromonas gingivalis-impaired innate immune response via NLRP3 proteolysis in endothelial cells. Innate Immun. 2015;21:65-72 pubmed publisher |
| Hafner Bratkovic I, Sušjan P, Lainšček D, Tapia Abellán A, Cerović K, Kadunc L, et al. NLRP3 lacking the leucine-rich repeat domain can be fully activated via the canonical inflammasome pathway. Nat Commun. 2018;9:5182 pubmed publisher |
| Marchetti C, Swartzwelter B, Koenders M, Azam T, Tengesdal I, Powers N, et al. NLRP3 inflammasome inhibitor OLT1177 suppresses joint inflammation in murine models of acute arthritis. Arthritis Res Ther. 2018;20:169 pubmed publisher |
| Qu W, Wang Y, Wu Y, Liu Y, Chen K, Liu X, et al. Triggering Receptors Expressed on Myeloid Cells 2 Promotes Corneal Resistance Against Pseudomonas aeruginosa by Inhibiting Caspase-1-Dependent Pyroptosis. Front Immunol. 2018;9:1121 pubmed publisher |
| Virreira Winter S, Zychlinsky A. The bacterial pigment pyocyanin inhibits the NLRP3 inflammasome through intracellular reactive oxygen and nitrogen species. J Biol Chem. 2018;293:4893-4900 pubmed publisher |
| Marchetti C, Swartzwelter B, Gamboni F, Neff C, Richter K, Azam T, et al. OLT1177, a ?-sulfonyl nitrile compound, safe in humans, inhibits the NLRP3 inflammasome and reverses the metabolic cost of inflammation. Proc Natl Acad Sci U S A. 2018;115:E1530-E1539 pubmed publisher |
| Clift D, McEwan W, Labzin L, Konieczny V, Mogessie B, James L, et al. A Method for the Acute and Rapid Degradation of Endogenous Proteins. Cell. 2017;171:1692-1706.e18 pubmed publisher |
| Dang E, McDonald J, Russell D, Cyster J. Oxysterol Restraint of Cholesterol Synthesis Prevents AIM2 Inflammasome Activation. Cell. 2017;171:1057-1071.e11 pubmed publisher |
| Li X, Thome S, Ma X, Amrute Nayak M, Finigan A, Kitt L, et al. MARK4 regulates NLRP3 positioning and inflammasome activation through a microtubule-dependent mechanism. Nat Commun. 2017;8:15986 pubmed publisher |
| Stutz A, Kolbe C, Stahl R, Horvath G, Franklin B, van Ray O, et al. NLRP3 inflammasome assembly is regulated by phosphorylation of the pyrin domain. J Exp Med. 2017;214:1725-1736 pubmed publisher |
| Bezbradica J, Coll R, Schroder K. Sterile signals generate weaker and delayed macrophage NLRP3 inflammasome responses relative to microbial signals. Cell Mol Immunol. 2017;14:118-126 pubmed publisher |
| de Torre Minguela C, Barberà Cremades M, Gómez A, MartÃn Sánchez F, PelegrÃn P. Macrophage activation and polarization modify P2X7 receptor secretome influencing the inflammatory process. Sci Rep. 2016;6:22586 pubmed publisher |
| MartÃn Sánchez F, Diamond C, Zeitler M, Gómez A, Baroja Mazo A, Bagnall J, et al. Inflammasome-dependent IL-1β release depends upon membrane permeabilisation. Cell Death Differ. 2016;23:1219-31 pubmed publisher |
| Yen H, Sugimoto N, Tobe T. Enteropathogenic Escherichia coli Uses NleA to Inhibit NLRP3 Inflammasome Activation. PLoS Pathog. 2015;11:e1005121 pubmed publisher |
| Satoh T, Kambe N, Matsue H. NLRP3 activation induces ASC-dependent programmed necrotic cell death, which leads to neutrophilic inflammation. Cell Death Dis. 2013;4:e644 pubmed publisher |
