This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Addgene
product type :
cDNA
product name :
pLIX-hN1ICD
catalog :
91897
citations: 5
Reference
Pearsall S, Williamson S, Humphrey S, Hughes E, Morgan D, Garc xed a Marqu xe9 s F, et al. Lineage plasticity in SCLC generates non-neuroendocrine cells primed for vasculogenic mimicry. J Thorac Oncol. 2023;: pubmed publisher
Schenk M, Humphrey S, Hossain A, Revill M, Pearsall S, Lallo A, et al. Soluble guanylate cyclase signalling mediates etoposide resistance in progressing small cell lung cancer. Nat Commun. 2021;12:6652 pubmed publisher
Roper N, Velez M, Chiappori A, Kim Y, Wei J, Sindiri S, et al. Notch signaling and efficacy of PD-1/PD-L1 blockade in relapsed small cell lung cancer. Nat Commun. 2021;12:3880 pubmed publisher
Zhang C, Martinez Ledesma E, Gao F, Zhang W, Ding J, Wu S, et al. Wild-type TP53 defined gamma-secretase inhibitor sensitivity and synergistic activity with doxorubicin in GSCs. Am J Cancer Res. 2019;9:1734-1745 pubmed
Derada Troletti C, Lopes Pinheiro M, Charabati M, Gowing E, Van het Hof B, van der Pol S, et al. Notch signaling is impaired during inflammation in a Lunatic Fringe-dependent manner. Brain Behav Immun. 2018;69:48-56 pubmed publisher
product information
Catalog Number :
91897
Product Name :
pLIX-hN1ICD
article :
doi
id25569
pubmed_id
bacterial resistance :
Ampicillin
cloning :
backbonepLIX_403
backbone_mutation
backbone_originDavid Root lab
backbone_size9396
promoter
sequencing_primer_3
sequencing_primer_5
vector_types
Mammalian Expression
Lentiviral
growth strain :
Doxycycline inducible expression of human Notch1 ICD
origin :
37
pi :
alt_names
N1ICD
Notch1-ICD
cloning
clone_methodGateway Cloning
cloning_site_3
cloning_site_5
promoterTRE promoter, Tet ON
sequencing_primer_3O.PGK1b-R (GAACGGACGTGAAGAATGTG)
sequencing_primer_5LNCX
site_3_destroyed
site_5_destroyed
entrez_gene
aliasesAOS5, AOVD1, TAN1, hN1
geneNOTCH1
id4851
genbank_ids
mutationcodons 1770 to 2555 of human NOTCH1
nameNotch1 intracellular domain
shRNA_sequence
size2360
species
9606
Homo sapiens
tags
plasmid copy :
Insert DNA obtained by PCR from MIG-NICD plasmid (Dr. Warren Pear)
resistance markers :
999
tags :
Unknown
terms :
Puromycin
company information
Addgene
490 Arsenal Way, Suite 100
Watertown, MA 02472
info@addgene.org
https://www.addgene.org
617.225.9000
headquarters: USA