This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Addgene
product type :
cDNA
product name :
pBABE puro H-Ras V12
catalog :
9051
citations: 24
Reference
Lee D, Kim I, Lee H, Seo M, Cho M, Lee H, et al. Akt enhances the vulnerability of cancer cells to VCP/p97 inhibition-mediated paraptosis. Cell Death Dis. 2024;15:48 pubmed publisher
Lee S, Yang J, Park U, Choi H, Kim Y, Yoon B, et al. SIRT1 ubiquitination is regulated by opposing activities of APC/C-Cdh1 and AROS during stress-induced premature senescence. Exp Mol Med. 2023;55:1232-1246 pubmed publisher
Palazzo A, Hernandez Vargas H, Goehrig D, M xe9 dard J, Vindrieux D, Flaman J, et al. Transformed cells after senescence give rise to more severe tumor phenotypes than transformed non-senescent cells. Cancer Lett. 2022;546:215850 pubmed publisher
von Joest M, Chen C, Douch xe9 T, Chantrel J, Chiche A, Gianetto Q, et al. Amphiregulin mediates non-cell-autonomous effect of senescence on reprogramming. Cell Rep. 2022;40:111074 pubmed publisher
Demir M, Cizmecioglu O. ZAP70 Activation Compensates for Loss of Class IA PI3K Isoforms Through Activation of the JAK-STAT3 Pathway. Cancer Diagn Progn. 2022;2:391-404 pubmed publisher
Small S, Tang E, Ragland R, Ruzankina Y, Schoppy D, Mandal R, et al. Induction of IL19 expression through JNK and cGAS-STING modulates DNA damage-induced cytokine production. Sci Signal. 2021;14:eaba2611 pubmed publisher
Verma A, Messerli S, Miskimins W. Lactate induces PD-L1 in HRASG12V-positive oropharyngeal squamous cell carcinoma. Oncotarget. 2020;11:1493-1504 pubmed publisher
Gasilina A, Premnauth G, Gurjar P, Biesiada J, Hegde S, Milewski D, et al. IODVA1, a guanidinobenzimidazole derivative, targets Rac activity and Ras-driven cancer models. PLoS ONE. 2020;15:e0229801 pubmed publisher
Kumazaki M, Shimomura I, Kiyono T, Ochiya T, Yamamoto Y. Cell-type specific tumorigenesis with Ras oncogenes in human lung epithelial cells. Biochem Biophys Res Commun. 2020;525:483-490 pubmed publisher
Leidal A, Huang H, Marsh T, Solvik T, Zhang D, Ye J, et al. The LC3-conjugation machinery specifies the loading of RNA-binding proteins into extracellular vesicles. Nat Cell Biol. 2020;22:187-199 pubmed publisher
McMahon M, Contreras A, Holm M, Uechi T, Forester C, Pang X, et al. A single H/ACA small nucleolar RNA mediates tumor suppression downstream of oncogenic RAS. elife. 2019;8: pubmed publisher
Rockfield S, Kee Y, Nanjundan M. Chronic iron exposure and c-Myc/H-ras-mediated transformation in fallopian tube cells alter the expression of EVI1, amplified at 3q26.2 in ovarian cancer. Oncogenesis. 2019;8:46 pubmed publisher
Ruiz P, Gamble M. MacroH2A1 chromatin specification requires its docking domain and acetylation of H2B lysine 20. Nat Commun. 2018;9:5143 pubmed publisher
Santinon G, Brian I, Pocaterra A, Romani P, Franzolin E, Rampazzo C, et al. dNTP metabolism links mechanical cues and YAP/TAZ to cell growth and oncogene-induced senescence. EMBO J. 2018;37: pubmed publisher
Rockfield S, Flores I, Nanjundan M. Expression and function of nuclear receptor coactivator 4 isoforms in transformed endometriotic and malignant ovarian cells. Oncotarget. 2018;9:5344-5367 pubmed publisher
Ku A, Shaver T, Rao A, Howard J, Rodriguez C, Miao Q, et al. TCF7L1 promotes skin tumorigenesis independently of β-catenin through induction of LCN2. elife. 2017;6: pubmed publisher
Madureira P, Bharadwaj A, Bydoun M, Garant K, O Connell P, Lee P, et al. Cell surface protease activation during RAS transformation: Critical role of the plasminogen receptor, S100A10. Oncotarget. 2016;7:47720-47737 pubmed publisher
Katamune C, Koyanagi S, Shiromizu S, Matsunaga N, Shimba S, Shibata S, et al. Different Roles of Negative and Positive Components of the Circadian Clock in Oncogene-induced Neoplastic Transformation. J Biol Chem. 2016;291:10541-50 pubmed publisher
Sung S, Choi J, Cheong H. Catabolic pathways regulated by mTORC1 are pivotal for survival and growth of cancer cells expressing mutant Ras. Oncotarget. 2015;6:40405-17 pubmed publisher
Koptyra M, Park T, Curran T. Crk and CrkL are required for cell transformation by v-fos and v-ras. Mol Carcinog. 2016;55:97-104 pubmed publisher
Ju H, Ahn S, Kim D, Baek S, Chung S, Seong J, et al. Investigation of oncogenic cooperation in simple liver-specific transgenic mouse models using noninvasive in vivo imaging. PLoS ONE. 2013;8:e59869 pubmed publisher
Baker D, Dawlaty M, Wijshake T, Jeganathan K, Malureanu L, van Ree J, et al. Increased expression of BubR1 protects against aneuploidy and cancer and extends healthy lifespan. Nat Cell Biol. 2013;15:96-102 pubmed publisher
Lal A, Thomas M, Altschuler G, Navarro F, O Day E, Li X, et al. Capture of microRNA-bound mRNAs identifies the tumor suppressor miR-34a as a regulator of growth factor signaling. PLoS Genet. 2011;7:e1002363 pubmed publisher
Neklesa T, Tae H, Schneekloth A, Stulberg M, Corson T, Sundberg T, et al. Small-molecule hydrophobic tagging-induced degradation of HaloTag fusion proteins. Nat Chem Biol. 2011;7:538-43 pubmed publisher
product information
Catalog Number :
9051
Product Name :
pBABE puro H-Ras V12
article :
doi
id355
pubmed_id
bacterial resistance :
Ampicillin
cloning :
backbonepBabe puro
backbone_mutation
backbone_origin
backbone_size5169
promoter
sequencing_primer_3
sequencing_primer_5
vector_types
Mammalian Expression
Retroviral
growth strain :
Retroviral expression of a constitutively active form of H-Ras
origin :
37
pi :
alt_names
v-Ha-ras
Hras
cloning
clone_methodRestriction Enzyme
cloning_site_3EcoRI
cloning_site_5BamHI
promoter
sequencing_primer_3pBABE-3
sequencing_primer_5pBABE-5
site_3_destroyed
site_5_destroyed
entrez_gene
aliasesC-BAS/HAS, C-H-RAS, C-HA-RAS1, CTLO, H-RASIDX, HAMSV, HRAS1, RASH1, p21ras
geneHRAS
id3265
genbank_ids
mutationG12V, constitutively active
nameHras V12
shRNA_sequence
size700
species
9606
Homo sapiens
tags
plasmid copy :
Scott Lowe, Robert Weinberg
resistance markers :
184
tags :
High Copy
terms :
Puromycin
company information
Addgene
490 Arsenal Way, Suite 100
Watertown, MA 02472
info@addgene.org
https://www.addgene.org
617.225.9000
headquarters: USA