This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Addgene
product type :
cDNA
product name :
1477 pcDNA3 flag HA Akt1
catalog :
9021
citations: 17
Reference
Chen P, Wang W, Wong S, Li J, Wu Q, Zhang S, et al. RUNDC3A regulates SNAP25-mediated chemotherapy resistance by binding AKT in gastric neuroendocrine carcinoma (GNEC). Cell Death Discov. 2022;8:296 pubmed publisher
Palma M, Leroy C, Salomé Desnoulez S, Werkmeister E, Kong R, Mongy M, et al. A role for AKT1 in nonsense-mediated mRNA decay. Nucleic Acids Res. 2021;49:11022-11037 pubmed publisher
Tooley A, Kazyken D, Bodur C, Gonzalez I, Fingar D. The innate immune kinase TBK1 directly increases mTORC2 activity and downstream signaling to Akt. J Biol Chem. 2021;297:100942 pubmed publisher
Wie J, Liu Z, Song H, Tropea T, Yang L, Wang H, et al. A growth-factor-activated lysosomal K+ channel regulates Parkinson's pathology. Nature. 2021;: pubmed publisher
Zhu L, Yang H, Chao Y, Gu Y, Zhang J, Wang F, et al. Akt phosphorylation regulated by IKKε in response to low shear stress leads to endothelial inflammation via activating IRF3. Cell Signal. 2021;80:109900 pubmed publisher
Yue X, Wu F, Li Y, Liu J, Boateng M, Mandava K, et al. Gain of function mutant p53 protein activates AKT through the Rac1 signaling to promote tumorigenesis. Cell Cycle. 2020;19:1338-1351 pubmed publisher
Chu N, Salguero A, Liu A, Chen Z, Dempsey D, Ficarro S, et al. Akt Kinase Activation Mechanisms Revealed Using Protein Semisynthesis. Cell. 2018;174:897-907.e14 pubmed publisher
Valentino E, Bellazzo A, Di Minin G, Sicari D, Apollonio M, Scognamiglio G, et al. Mutant p53 potentiates the oncogenic effects of insulin by inhibiting the tumor suppressor DAB2IP. Proc Natl Acad Sci U S A. 2017;114:7623-7628 pubmed publisher
Fei L, Ma Y, Zhang M, Liu X, Luo Y, Wang C, et al. RACK1 promotes lung cancer cell growth via an MCM7/RACK1/ Akt signaling complex. Oncotarget. 2017;8:40501-40513 pubmed publisher
Tobisawa T, Yano T, Tanno M, Miki T, Kuno A, Kimura Y, et al. Insufficient activation of Akt upon reperfusion because of its novel modification by reduced PP2A-B55α contributes to enlargement of infarct size by chronic kidney disease. Basic Res Cardiol. 2017;112:31 pubmed publisher
Pinton G, Zonca S, Manente A, Cavaletto M, Borroni E, Daga A, et al. SIRT1 at the crossroads of AKT1 and ERβ in malignant pleural mesothelioma cells. Oncotarget. 2016;7:14366-79 pubmed publisher
De Marco C, Malanga D, Rinaldo N, De Vita F, Scrima M, Lovisa S, et al. Mutant AKT1-E17K is oncogenic in lung epithelial cells. Oncotarget. 2015;6:39634-50 pubmed publisher
Lopez S, Hodgson M, Packianathan C, Bingöl Özakpınar Ö, Uras F, Rosen B, et al. Determinants of the tumor suppressor INPP4B protein and lipid phosphatase activities. Biochem Biophys Res Commun. 2013;440:277-82 pubmed publisher
Wu X, Bhayani M, Dodge C, Nicoloso M, Chen Y, Yan X, et al. Coordinated targeting of the EGFR signaling axis by microRNA-27a*. Oncotarget. 2013;4:1388-98 pubmed
Wang S, Huang X, Sun D, Xin X, Pan Q, Peng S, et al. Extensive crosstalk between O-GlcNAcylation and phosphorylation regulates Akt signaling. PLoS ONE. 2012;7:e37427 pubmed publisher
Martin V, Wang W, Lipchik A, Parker L, He Y, Zhang S, et al. Akt2 inhibits the activation of NFAT in lymphocytes by modulating calcium release from intracellular stores. Cell Signal. 2012;24:1064-73 pubmed publisher
Hsieh A, Bo R, Manola J, Vazquez F, Bare O, Khvorova A, et al. A library of siRNA duplexes targeting the phosphoinositide 3-kinase pathway: determinants of gene silencing for use in cell-based screens. Nucleic Acids Res. 2004;32:893-901 pubmed
product information
Catalog Number :
9021
Product Name :
1477 pcDNA3 flag HA Akt1
article :
doi10.1093/nar/gkh238
id350
pubmed_id14769947
bacterial resistance :
Ampicillin
cloning :
backbonepcDNA3
backbone_mutation
backbone_originInvitrogen
backbone_size5446
promoter
sequencing_primer_3
sequencing_primer_5
vector_types
Mammalian Expression
origin :
37
pi :
alt_names
Akt
cloning
clone_methodRestriction Enzyme
cloning_site_3XbaI
cloning_site_5BamHI
promoter
sequencing_primer_3BGH-rev
sequencing_primer_5CMV-F
site_3_destroyed
site_5_destroyed
entrez_gene
aliasesAKT, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA
geneAKT1
id207
genbank_ids
mutation
nameAkt1
shRNA_sequence
size1500
species
9606
Homo sapiens
tags
locationN terminal on backbone
tagflag
locationN terminal on backbone
tagHA
resistance markers :
455
tags :
High Copy
terms :
Neomycin (select with G418)
company information
Addgene
490 Arsenal Way, Suite 100
Watertown, MA 02472
info@addgene.org
https://www.addgene.org
617.225.9000
headquarters: USA